Detailed information NTG0326035

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: EGX80_RS04960
• Genome accession: NZ_CP033815
• Coordinates: 936952..938175 (+)
• Length: 407 a.a.
• NCBI ID: WP_002994926.1
• Uniprot ID: A0A4U9TAA9
• Organism: Streptococcus pyogenes strain FDAARGOS_514
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 931952..943175

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EGX80_RS04945 (EGX80_04955)	-	934887..935867 (-)	981	WP_162988407.1	IS30 family transposase	-
EGX80_RS04955 (EGX80_04965)	rlmH	936262..936741 (-)	480	WP_002994924.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EGX80_RS04960 (EGX80_04970)	htrA	936952..938175 (+)	1224	WP_002994926.1	trypsin-like peptidase domain-containing protein	Regulator
EGX80_RS04965 (EGX80_04975)	spo0J	938264..939040 (+)	777	WP_002994930.1	ParB/RepB/Spo0J family partition protein	Regulator
EGX80_RS04970 (EGX80_04980)	dnaA	939273..940628 (+)	1356	WP_002987659.1	chromosomal replication initiator protein DnaA	-
EGX80_RS04975 (EGX80_04985)	dnaN	940783..941919 (+)	1137	WP_011054084.1	DNA polymerase III subunit beta	-
EGX80_RS04980 (EGX80_04990)	-	941994..942191 (+)	198	WP_002981933.1	DUF951 family protein	-

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 42760.38 Da
• Isoelectric Point: 7.3920

>NTDB_id=326035 EGX80_RS04960 WP_002994926.1 936952..938175(+) (htrA) [Streptococcus pyogenes strain FDAARGOS_514]
MPSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Nucleotide

• Length: 1224 bp

>NTDB_id=326035 EGX80_RS04960 WP_002994926.1 936952..938175(+) (htrA) [Streptococcus pyogenes strain FDAARGOS_514]
ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTATTTTACTAATTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTCAATAATCTCTACCCACATTCTCCTTCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTTGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
TCCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGGATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAAATAAAAACAGTAGCTGAATTTGCAGACTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAACCCTGGAAACTCT
GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGATGTTATTAAAATTATTAAACAGCTAGAAA
CTAATGGTGAAGTTATCAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGATTTATCCACAAATGCTCTTAGCCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAACAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (109-254)

• PDZ domain (PDZ_2) (301-396)

3D structure

• AlphaFold DB: A0A4U9TAA9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.881	99.263	0.614
htrA	Streptococcus gordonii str. Challis substr. CH1	55.224	98.771	0.545
htrA	Streptococcus mitis NCTC 12261	53.071	100	0.531
htrA	Streptococcus pneumoniae Rx1	52.826	100	0.528
htrA	Streptococcus pneumoniae D39	52.826	100	0.528
htrA	Streptococcus pneumoniae R6	52.826	100	0.528
htrA	Streptococcus pneumoniae TIGR4	52.826	100	0.528