Detailed information NTG0324453

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: EGC57_RS00330
• Genome accession: NZ_CP033621
• Coordinates: 53252..54163 (+)
• Length: 303 a.a.
• NCBI ID: WP_020904818.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain M75
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48252..59163

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EGC57_RS00310 (EGC57_00310)	purE	48536..49027 (+)	492	WP_002986689.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
EGC57_RS00315 (EGC57_00315)	purK	49014..50087 (+)	1074	WP_164997029.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
EGC57_RS00320 (EGC57_00320)	-	50114..51811 (+)	1698	WP_020904816.1	AIPR family protein	-
EGC57_RS00325 (EGC57_00325)	purB	51829..53121 (+)	1293	WP_020904817.1	adenylosuccinate lyase	-
EGC57_RS00330 (EGC57_00330)	comR	53252..54163 (+)	912	WP_020904818.1	XRE family transcriptional regulator	Regulator
EGC57_RS09620	comS	54254..54352 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
EGC57_RS00335 (EGC57_00335)	ruvB	54383..55381 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
EGC57_RS00340 (EGC57_00340)	-	55519..55956 (+)	438	WP_020904819.1	low molecular weight protein-tyrosine-phosphatase	-
EGC57_RS00345 (EGC57_00345)	-	55980..56381 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
EGC57_RS00350 (EGC57_00350)	-	56378..58153 (+)	1776	WP_076639715.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35887.54 Da
• Isoelectric Point: 4.9349

>NTDB_id=324453 EGC57_RS00330 WP_020904818.1 53252..54163(+) (comR) [Streptococcus pyogenes strain M75]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDAQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=324453 EGC57_RS00330 WP_020904818.1 53252..54163(+) (comR) [Streptococcus pyogenes strain M75]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGCACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAGGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366