Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   EB816_RS02395 Genome accession   NZ_CP033337
Coordinates   438834..439544 (+) Length   236 a.a.
NCBI ID   WP_023612167.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY453     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 433834..444544
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EB816_RS02375 (EB816_02380) - 434686..434835 (+) 150 WP_002990686.1 hypothetical protein -
  EB816_RS02380 (EB816_02385) - 435230..436378 (+) 1149 WP_023612171.1 acetyl-CoA C-acyltransferase -
  EB816_RS02385 (EB816_02390) - 436335..437582 (+) 1248 WP_023612155.1 AMP-binding protein -
  EB816_RS02390 (EB816_02395) - 437638..438672 (+) 1035 WP_011284595.1 DUF3114 domain-containing protein -
  EB816_RS02395 (EB816_02400) vicR 438834..439544 (+) 711 WP_023612167.1 response regulator YycF Regulator
  EB816_RS02400 (EB816_02405) vicK 439537..440889 (+) 1353 WP_023078748.1 cell wall metabolism sensor histidine kinase VicK Regulator
  EB816_RS02405 (EB816_02410) vicX 440893..441702 (+) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  EB816_RS02410 (EB816_02415) rnc 442133..442825 (+) 693 WP_002990670.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27112.00 Da        Isoelectric Point: 4.9038

>NTDB_id=323124 EB816_RS02395 WP_023612167.1 438834..439544(+) (vicR) [Streptococcus pyogenes strain TSPY453]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEERPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=323124 EB816_RS02395 WP_023612167.1 438834..439544(+) (vicR) [Streptococcus pyogenes strain TSPY453]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAGGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCACGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGGCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364

Multiple sequence alignment