Detailed information NTG0318869

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: FC629_RS12170
• Genome accession: NZ_CP039988
• Coordinates: 2551513..2552184 (+)
• Length: 223 a.a.
• NCBI ID: WP_003090494.1
• Uniprot ID: A0A0H2ZC88
• Organism: Pseudomonas aeruginosa strain T2436
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2546513..2557184

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FC629_RS12135 (FC629_12465)	ppyR	2546986..2547243 (+)	258	WP_003090502.1	psl/pyoverdine operon transcriptional regulator PpyR	-
FC629_RS12140 (FC629_12470)	-	2547230..2548423 (+)	1194	WP_031685718.1	NnrS family protein	-
FC629_RS12145 (FC629_12475)	-	2548424..2548690 (-)	267	WP_079385751.1	DUF5329 domain-containing protein	-
FC629_RS12150 (FC629_12480)	-	2548674..2549567 (-)	894	WP_003090499.1	hypothetical protein	-
FC629_RS12155 (FC629_12485)	-	2549594..2550676 (-)	1083	WP_096248838.1	hypothetical protein	-
FC629_RS12160 (FC629_12490)	-	2550891..2551199 (+)	309	WP_003090497.1	PepSY domain-containing protein	-
FC629_RS12165 (FC629_12495)	-	2551199..2551513 (+)	315	WP_003131079.1	PepSY domain-containing protein	-
FC629_RS12170 (FC629_12500)	ciaR	2551513..2552184 (+)	672	WP_003090494.1	two-component system response regulator CarR	Regulator
FC629_RS12175 (FC629_12505)	carS	2552181..2553518 (+)	1338	WP_003090493.1	two-component system sensor histidine kinase CarS	-
FC629_RS12180 (FC629_12510)	-	2553609..2553917 (+)	309	WP_003097699.1	hypothetical protein	-
FC629_RS34920	-	2553922..2554677 (-)	756	WP_409513189.1	methyl-accepting chemotaxis protein	-
FC629_RS34925	-	2554828..2556066 (-)	1239	Protein_2414	chemotaxis protein	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 24729.20 Da
• Isoelectric Point: 5.8445

>NTDB_id=318869 FC629_RS12170 WP_003090494.1 2551513..2552184(+) (ciaR) [Pseudomonas aeruginosa strain T2436]
MRLLLVEDHVPLADELMASLTRQGYAVDWLADGRDAAVQGASEPYDLIILDLGLPGRPGLEILQEWRGLGLATPVLILTA
RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLRLDEQRQCVCLNGADVDLTAAEFRLLR
YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAAG

Nucleotide

• Length: 672 bp

>NTDB_id=318869 FC629_RS12170 WP_003090494.1 2551513..2552184(+) (ciaR) [Pseudomonas aeruginosa strain T2436]
ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCCCTGGCCGACGAACTGATGGCCAGCCTGACCCGCCAGGGCTACGCGGT
GGACTGGCTGGCCGACGGCCGCGACGCGGCGGTGCAGGGCGCCAGCGAGCCCTACGACCTGATCATCCTCGACCTCGGCC
TGCCCGGGCGCCCCGGCCTGGAGATACTCCAGGAGTGGCGTGGGCTGGGACTCGCGACTCCGGTGCTGATCCTCACCGCG
CGCGGTTCCTGGGCCGAACGCATCGATGGCCTCAAGGCCGGTGCCGACGACTACCTGACCAAGCCGTTCCATCCGGAAGA
GTTGGCCTTGCGCATCCAGGCCCTGTTGCGCCGCGCCCATGGGCTGGCCAACCAGAGCCAGCTGGAGGCCGCTGGGCTGC
GCCTGGACGAGCAGCGCCAGTGCGTGTGCCTGAACGGCGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGC
TATTTCATGCTGCACCCCGGCCAGGTCCTGTCCAAGGGGCACCTGGCCGAGCATCTGTACGACGGCGAGACCGAACGCGA
TTCCAATGTCATCGAGGTCCACGTCAACCACTTGCGGCGCAAGCTCGGCCGCGAGGTGATCGAGACCCGCCGTGGCCAGG
GCTACCGCTACGCCGGGGTGGCCGCCGGATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-216)

3D structure

• AlphaFold DB: A0A0H2ZC88

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	37.727	98.655	0.372
ciaR	Streptococcus pneumoniae Rx1	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae D39	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae R6	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae TIGR4	37.273	98.655	0.368
micA	Streptococcus pneumoniae Cp1015	35.683	100	0.363
vicR	Streptococcus mutans UA159	35.526	100	0.363