Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   D8S77_RS01375 Genome accession   NZ_CP032700
Coordinates   251111..251872 (+) Length   253 a.a.
NCBI ID   WP_002986029.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY556     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 246111..256872
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D8S77_RS01360 (D8S77_01365) - 246369..247937 (-) 1569 WP_011285384.1 ABC transporter substrate-binding protein/permease -
  D8S77_RS01365 (D8S77_01370) - 248135..250060 (+) 1926 WP_129321672.1 DUF2207 domain-containing protein -
  D8S77_RS01370 (D8S77_01375) - 250126..250965 (+) 840 WP_002986031.1 undecaprenyl-diphosphate phosphatase -
  D8S77_RS01375 (D8S77_01380) mecA 251111..251872 (+) 762 WP_002986029.1 adaptor protein MecA Regulator
  D8S77_RS01380 (D8S77_01385) - 251879..253048 (+) 1170 WP_014407298.1 glycosyltransferase family 4 protein -
  D8S77_RS01385 (D8S77_01390) sufC 253170..253940 (+) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  D8S77_RS01390 (D8S77_01395) sufD 254035..255297 (+) 1263 WP_047235146.1 Fe-S cluster assembly protein SufD -
  D8S77_RS01395 (D8S77_01400) - 255328..256554 (+) 1227 WP_129321673.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29051.72 Da        Isoelectric Point: 4.1622

>NTDB_id=318305 D8S77_RS01375 WP_002986029.1 251111..251872(+) (mecA) [Streptococcus pyogenes strain TSPY556]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=318305 D8S77_RS01375 WP_002986029.1 251111..251872(+) (mecA) [Streptococcus pyogenes strain TSPY556]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.235

100

0.486
  mecA Streptococcus pneumoniae D39

48.235

100

0.486
  mecA Streptococcus pneumoniae R6

48.235

100

0.486
  mecA Streptococcus pneumoniae TIGR4

48.235

100

0.486

Multiple sequence alignment