Detailed information NTG0317726

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: MGAS27961_RS00330
• Genome accession: NZ_CP032665
• Coordinates: 52788..53699 (+)
• Length: 303 a.a.
• NCBI ID: WP_060383922.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain MGAS27961
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47788..58699

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS27961_RS00310 (MGAS27961_00310)	purE	48374..48865 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
MGAS27961_RS00315 (MGAS27961_00315)	purK	48852..49925 (+)	1074	WP_021340856.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
MGAS27961_RS00320 (MGAS27961_00320)	-	49927..51345 (+)	1419	WP_011888524.1	hypothetical protein	-
MGAS27961_RS00325 (MGAS27961_00325)	purB	51365..52657 (+)	1293	WP_011284409.1	adenylosuccinate lyase	-
MGAS27961_RS00330 (MGAS27961_00330)	comR	52788..53699 (+)	912	WP_060383922.1	transcriptional regulator Rgg4/ComR	Regulator
MGAS27961_RS09735	comS	53781..53882 (+)	102	WP_391592286.1	quorum-sensing system DWW-type pheromone	Regulator
MGAS27961_RS00335 (MGAS27961_00335)	ruvB	53929..54927 (+)	999	WP_011054100.1	Holliday junction branch migration DNA helicase RuvB	-
MGAS27961_RS00340 (MGAS27961_00340)	-	55065..55502 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
MGAS27961_RS00345 (MGAS27961_00345)	-	55525..55926 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
MGAS27961_RS00350 (MGAS27961_00350)	-	55923..57698 (+)	1776	WP_011284411.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35738.23 Da
• Isoelectric Point: 4.4854

>NTDB_id=317726 MGAS27961_RS00330 WP_060383922.1 52788..53699(+) (comR) [Streptococcus pyogenes strain MGAS27961]
MLEHFGGKVKVLRLEKRISHEDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=317726 MGAS27961_RS00330 WP_060383922.1 52788..53699(+) (comR) [Streptococcus pyogenes strain MGAS27961]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCACGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (26-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	99.67	100	0.997
comR	Streptococcus pyogenes MGAS315	58.333	99.01	0.578
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.027	96.37	0.492
comR	Streptococcus mutans UA159	46.358	99.67	0.462