Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   D6869_RS12010 Genome accession   NZ_CP032526
Coordinates   2362246..2363469 (+) Length   407 a.a.
NCBI ID   WP_011836058.1    Uniprot ID   A0A1E7G0Y5
Organism   Lactococcus cremoris strain 4B0     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2357246..2368469
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D6869_RS11985 (D6869_12140) - 2358360..2359163 (-) 804 WP_011836053.1 phosphatidate cytidylyltransferase -
  D6869_RS11990 (D6869_12145) - 2359163..2359897 (-) 735 WP_011836054.1 isoprenyl transferase -
  D6869_RS11995 (D6869_12150) yajC 2360248..2360580 (-) 333 WP_011836055.1 preprotein translocase subunit YajC -
  D6869_RS12000 (D6869_12155) - 2360675..2361373 (-) 699 WP_011836056.1 DNA alkylation repair protein -
  D6869_RS12005 (D6869_12160) rlmH 2361391..2361870 (-) 480 WP_011836057.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  D6869_RS12010 (D6869_12165) htrA 2362246..2363469 (+) 1224 WP_011836058.1 S1C family serine protease Regulator
  D6869_RS12015 (D6869_12170) - 2363589..2364587 (+) 999 WP_011836059.1 glycosyltransferase -
  D6869_RS12020 (D6869_12175) - 2364733..2366073 (+) 1341 WP_011836060.1 glycosyltransferase family 4 protein -
  D6869_RS12025 (D6869_12180) - 2366181..2366405 (+) 225 WP_003130579.1 YkuJ family protein -
  D6869_RS12030 (D6869_12185) - 2366549..2367553 (+) 1005 WP_011836061.1 hypothetical protein -
  D6869_RS12035 (D6869_12190) - 2367610..2368362 (-) 753 WP_011836062.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -

Sequence

Protein


Download         Length: 407 a.a.        Molecular weight: 41540.99 Da        Isoelectric Point: 5.3802

>NTDB_id=316739 D6869_RS12010 WP_011836058.1 2362246..2363469(+) (htrA) [Lactococcus cremoris strain 4B0]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQLGNANRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKQNS
QSDFSSIFGGNSGSSSANDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKATVVGYDEYTDLAVL
KISSDHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTSINAIQTDAAINPGNSGG
ALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLETDGKISRPALGIRMVDLSQLSTNDSSQLKLPSS
VTGGVVVYSVQAGLPAATAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSATANVKLSKSTSDLET
NSSSSSN

Nucleotide


Download         Length: 1224 bp        

>NTDB_id=316739 D6869_RS12010 WP_011836058.1 2362246..2363469(+) (htrA) [Lactococcus cremoris strain 4B0]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACCGGTGTTGTGGGTGGAGCTATCGCACTCGGAGGAAGCGCAATTTA
TCAAAGCACTACAAACCAACTAGGAAATGCTAACCGCTCAAATACGACTAGCACAAAGGTTAGTAATGTTTCGGTAAATG
TCAATACCGATGTTACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAACAGAATTCA
CAAAGTGATTTTAGTTCAATTTTTGGTGGAAATAGCGGCTCAAGTTCAGCTAATGACGGCTTGCAACTTTCCAGTGAGGG
TTCTGGTGTTATTTACAAAAAATCTGGTGGAGATGCTTACGTGGTCACTAACTATCACGTTATTGCCGGAAATAGTTCCC
TCGATGTTTTACTTTCTGGTGGGCAAAAAGTTAAAGCCACAGTTGTTGGTTATGATGAATACACTGACCTTGCCGTTCTT
AAAATCAGCTCTGACCATGTTAAAGACGTGGCAACTTTCGCTGATTCAAGCAAGTTAACTATTGGTGAACCAGCTATTGC
AGTCGGCTCACCTTTAGGTAGCCAGTTTGCTAATACTGCAACCGAAGGAATTCTGTCTGCAACAAGTCGTCAAGTCACTT
TGACTCAAGAAAATGGTCAAACAACAAGTATCAATGCGATTCAAACGGATGCTGCCATTAACCCTGGTAACTCAGGTGGA
GCCTTGATTAATATTGAAGGTCAAGTGATTGGTATTACTCAAAGTAAAATCACAACGACTGAAGATGGTTCTACCTCTGT
GGAAGGTTTAGGTTTTGCTATCCCATCTAATGATGTGGTAAACATCATTAATAAACTTGAAACTGATGGTAAGATTTCAC
GTCCTGCCTTAGGTATTCGTATGGTTGACCTATCTCAATTATCAACAAATGATAGTTCTCAACTGAAATTACCTAGCAGC
GTAACTGGTGGAGTGGTTGTCTACTCTGTTCAAGCGGGTCTTCCTGCTGCCACAGCTGGTCTGAAAGCTGGCGATGTGAT
AACGAAGGTGGGAGATACCGCCGTTACTTCATCAACAGACTTACAAAGTGCTCTTTACTCACACAATATTAATGATACTG
TGAAAGTCACCTACTACCGTGATGGTAAATCAGCCACAGCAAATGTCAAACTCTCTAAATCAACAAGCGATTTAGAAACA
AATAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(250-395)

Trypsin-like peptidase domain (Trypsin_2)

(107-252)

PDZ domain (PDZ_2)

(295-391)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1E7G0Y5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

55.128

95.823

0.528
  htrA Streptococcus mitis NCTC 12261

55.875

94.103

0.526
  htrA Streptococcus pneumoniae R6

58.14

84.521

0.491
  htrA Streptococcus pneumoniae TIGR4

58.14

84.521

0.491
  htrA Streptococcus pneumoniae D39

58.14

84.521

0.491
  htrA Streptococcus pneumoniae Rx1

58.14

84.521

0.491
  htrA Streptococcus mutans UA159

53.388

90.663

0.484

Multiple sequence alignment