Detailed information    

insolico Bioinformatically predicted

Overview

Name   pilC   Type   Machinery gene
Locus tag   CH628_RS04460 Genome accession   NZ_CP031681
Coordinates   834514..835734 (+) Length   406 a.a.
NCBI ID   WP_011271971.1    Uniprot ID   Q4QNP6
Organism   Haemophilus influenzae strain P669-6977     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 829514..840734
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CH628_RS04440 (CH628_04440) corC 830481..831380 (-) 900 WP_005656283.1 CNNM family magnesium/cobalt transport protein CorC -
  CH628_RS04445 (CH628_04445) ampD 832002..832562 (-) 561 WP_011271974.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
  CH628_RS04450 (CH628_04450) pilA 832677..833126 (+) 450 WP_011271973.1 prepilin-type N-terminal cleavage/methylation domain-containing protein Machinery gene
  CH628_RS04455 (CH628_04455) pilB 833123..834517 (+) 1395 WP_011271972.1 GspE/PulE family protein Machinery gene
  CH628_RS04460 (CH628_04460) pilC 834514..835734 (+) 1221 WP_011271971.1 type II secretion system F family protein Machinery gene
  CH628_RS04465 (CH628_04465) pilD 835731..836423 (+) 693 WP_105886719.1 A24 family peptidase Machinery gene
  CH628_RS04470 (CH628_04470) rho 836477..837739 (-) 1263 WP_015701557.1 transcription termination factor Rho -
  CH628_RS04475 (CH628_04475) metJ 837987..838304 (+) 318 WP_005631186.1 met regulon transcriptional regulator MetJ -
  CH628_RS04480 (CH628_04480) - 838318..838704 (-) 387 WP_105886720.1 Cu(I)-responsive transcriptional regulator -
  CH628_RS04485 (CH628_04485) - 838781..838987 (+) 207 WP_005631184.1 heavy-metal-associated domain-containing protein -
  CH628_RS04490 (CH628_04490) - 839073..839279 (+) 207 WP_005656255.1 heavy-metal-associated domain-containing protein -
  CH628_RS04495 (CH628_04495) - 839365..839571 (+) 207 WP_005656255.1 heavy-metal-associated domain-containing protein -

Sequence

Protein


Download         Length: 406 a.a.        Molecular weight: 46259.57 Da        Isoelectric Point: 10.0444

>NTDB_id=309889 CH628_RS04460 WP_011271971.1 834514..835734(+) (pilC) [Haemophilus influenzae strain P669-6977]
MTKKLFYYQGSNALNQKQKGSIIADTKQQAHFQLISRGLTHIKLQQNWQFGAKPKNSEISELLNQLATLLQSVIPLKNSL
QILQQNCTQIMLNKWLERLLQSIESGLAFSQAIEQQGKYLTQQEIQLIQVGEMTGKLAVVCKKIATHRSQSLALQRKLQK
IMLYPSMVLGISLLLTLALLLFIAPQFAEMYSGNNAELPTITAILLSISNFLKQNIGILLFFVLSFFLFYYFYLKRQTWF
HQKKNQLISITPIFGTIQKLSRLVNFSQSLQIMLQAGVPLNQALDSFLPRTQTWQTKKTLVNDMVLDKEVRSILQWVSQG
YAFSNSVSSDLFPMEAQQMLQIGEQSGKLALMLEHIADNYQEKLNHQIDLLSQMLEPLMMVIIGSLIGIIMMGMYLPIFN
MGSVIQ

Nucleotide


Download         Length: 1221 bp        

>NTDB_id=309889 CH628_RS04460 WP_011271971.1 834514..835734(+) (pilC) [Haemophilus influenzae strain P669-6977]
ATGACTAAAAAACTCTTTTATTATCAAGGTAGTAACGCATTAAATCAGAAACAAAAAGGCTCAATTATTGCGGATACGAA
ACAACAAGCGCACTTTCAGTTAATAAGCCGCGGGCTTACTCACATCAAATTACAACAAAACTGGCAATTTGGGGCAAAAC
CCAAAAATTCAGAAATCAGTGAATTACTCAATCAATTAGCGACATTGCTACAGTCCGTAATTCCGTTAAAAAACAGCCTA
CAAATTTTGCAACAAAATTGTACTCAAATTATGCTCAACAAATGGCTTGAACGACTGCTTCAATCCATTGAATCTGGCTT
AGCATTCTCACAAGCCATTGAACAACAAGGAAAATATCTCACACAACAAGAAATTCAACTGATTCAAGTGGGAGAAATGA
CAGGAAAACTTGCCGTAGTTTGTAAAAAAATAGCCACGCACCGTAGTCAATCTTTGGCTTTACAACGCAAATTACAGAAA
ATTATGTTATATCCCTCAATGGTATTGGGAATTTCTCTATTATTGACACTCGCATTACTGCTTTTTATCGCGCCTCAATT
TGCTGAAATGTACAGTGGCAATAATGCGGAGTTACCAACAATAACCGCAATATTGCTCTCAATATCTAATTTCCTTAAGC
AAAATATTGGCATTTTGCTATTTTTCGTTTTGAGTTTTTTTCTATTTTATTATTTCTATCTAAAACGCCAGACTTGGTTT
CATCAAAAGAAAAATCAACTTATTTCTATCACGCCTATTTTTGGCACAATTCAAAAGCTTTCACGTTTAGTGAACTTTAG
TCAAAGTTTACAAATTATGTTGCAGGCCGGCGTACCGCTTAATCAGGCACTAGACAGTTTTCTTCCTCGCACACAAACTT
GGCAAACCAAGAAAACGCTTGTAAACGATATGGTATTAGATAAAGAAGTGCGGTCAATTTTGCAATGGGTTTCTCAAGGC
TATGCGTTTTCTAATAGCGTAAGTAGCGATCTTTTCCCGATGGAAGCACAACAAATGCTACAAATTGGCGAACAAAGCGG
AAAACTCGCTTTGATGCTAGAGCATATCGCAGATAATTACCAAGAAAAACTTAATCATCAAATTGACTTACTCTCACAAA
TGCTAGAACCATTAATGATGGTAATCATCGGCAGTCTGATTGGGATTATTATGATGGGAATGTATTTACCTATCTTTAAT
ATGGGATCAGTTATTCAATGA

Domains

Predicted by InterproScan.

Type II secretion system (T2SS), protein F (T2SSF)

(63-185)

Type II secretion system (T2SS), protein F (T2SSF)

(266-397)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4QNP6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pilC Haemophilus influenzae 86-028NP

100

100

1
  pilC Haemophilus influenzae Rd KW20

97.783

100

0.978
  pilC Glaesserella parasuis strain SC1401

38.155

98.768

0.377

Multiple sequence alignment