Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   SPCG_RS05570 Genome accession   NC_010582
Coordinates   1047177..1047881 (+) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae CGSP14     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1042177..1052881
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPCG_RS05550 (SPCG_1071) coaC 1042466..1043017 (-) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -
  SPCG_RS05555 (SPCG_1072) coaB 1043029..1043718 (-) 690 WP_000699488.1 phosphopantothenate--cysteine ligase -
  SPCG_RS05560 (SPCG_1073) - 1043948..1045618 (+) 1671 WP_000845290.1 formate--tetrahydrofolate ligase -
  SPCG_RS05565 (SPCG_1074) mutY 1045947..1047122 (+) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  SPCG_RS05570 (SPCG_1075) micA 1047177..1047881 (+) 705 WP_000722076.1 response regulator YycF Regulator
  SPCG_RS05575 (SPCG_1076) micB 1047874..1049223 (+) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  SPCG_RS05580 (SPCG_1077) vicX 1049225..1050034 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  SPCG_RS05585 (SPCG_1078) relB 1050125..1050367 (+) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  SPCG_RS05590 (SPCG_1079) - 1050369..1050623 (+) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  SPCG_RS05595 (SPCG_1080) - 1050670..1051322 (+) 653 Protein_1062 potassium channel family protein -
  SPCG_RS05600 (SPCG_1081) - 1051582..1052568 (-) 987 WP_000204727.1 L-lactate dehydrogenase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=30613 SPCG_RS05570 WP_000722076.1 1047177..1047881(+) (micA) [Streptococcus pneumoniae CGSP14]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=30613 SPCG_RS05570 WP_000722076.1 1047177..1047881(+) (micA) [Streptococcus pneumoniae CGSP14]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACAAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment