Detailed information NTG0304914

Bioinformatically predicted

Overview

• Name: comE
• Type: Machinery gene
• Locus tag: DV378_RS04640
• Genome accession: NZ_CP031249
• Coordinates: 938451..939794 (-)
• Length: 447 a.a.
• NCBI ID: WP_050948867.1
• Uniprot ID: -
• Organism: Haemophilus influenzae strain M15895
• Function: type IV pilus biogenesis and function (predicted from homology) DNA binding and uptake

Genomic Context

Location: 933451..944794

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DV378_RS04610	-	934383..934655 (-)	273	WP_005630954.1	HU family DNA-binding protein	-
DV378_RS04615	-	934794..935384 (-)	591	WP_021034387.1	YjaG family protein	-
DV378_RS04620	nudC	935420..936214 (-)	795	WP_021034386.1	NAD(+) diphosphatase	-
DV378_RS04625	nfuA	936282..936878 (-)	597	WP_021034385.1	Fe-S biogenesis protein NfuA	-
DV378_RS04630	-	936954..937640 (-)	687	WP_050948865.1	ComF family protein	-
DV378_RS04635	tnpA	937999..938454 (-)	456	WP_050948866.1	IS200/IS605 family transposase	-
DV378_RS04640	comE	938451..939794 (-)	1344	WP_050948867.1	type IV pilus secretin PilQ	Machinery gene
DV378_RS04645	comD	939804..940217 (-)	414	WP_050948868.1	pilus assembly protein PilP	Machinery gene
DV378_RS04650	comC	940214..940735 (-)	522	WP_050948869.1	competence protein ComC	Machinery gene
DV378_RS04655	comB	940732..941241 (-)	510	WP_050948870.1	hypothetical protein	Machinery gene
DV378_RS04660	comA	941242..942039 (-)	798	WP_050948871.1	pilus assembly protein PilM	Machinery gene
DV378_RS04665	-	942138..944738 (+)	2601	WP_050948872.1	penicillin-binding protein 1A	-

Sequence

Protein

• Length: 447 a.a.
• Molecular weight: 49341.57 Da
• Isoelectric Point: 6.8467

>NTDB_id=304914 DV378_RS04640 WP_050948867.1 938451..939794(-) (comE) [Haemophilus influenzae strain M15895]
MKKYFLKCGYFLVCFCLPLIVFANPKTDNERFFIRLSQAPLAQTLEQLAFQQDVNLVMDEALESNISLRLDNIDMPRLLQ
IIAKSKKLTLNKDEGIYYLNGGQSGKGQVAGNLTTNEPHLMSHTVKLHFAKASELMKSLTTGSGSLLSSAGSITFDDRSN
LLVIQDEPRSVQNIKKLIAEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENAARVAGSLSGNSFENIADNLNVN
FATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYIVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVSYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKKLQ

Nucleotide

• Length: 1344 bp

>NTDB_id=304914 DV378_RS04640 WP_050948867.1 938451..939794(-) (comE) [Haemophilus influenzae strain M15895]
ATGAAGAAATATTTTTTAAAGTGCGGTTATTTTTTAGTCTGTTTTTGTTTGCCATTAATCGTTTTTGCTAATCCCAAAAC
TGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCCCAAACATTGGAACAGTTGGCTTTTCAACAAGATG
TGAATTTAGTGATGGATGAAGCATTAGAAAGTAATATTTCATTGAGATTAGATAATATTGATATGCCACGTTTACTACAA
ATAATCGCTAAAAGTAAGAAGCTTACTTTGAATAAAGATGAGGGTATTTACTATCTGAATGGAGGGCAATCAGGCAAAGG
GCAAGTTGCAGGAAATCTTACTACAAATGAACCGCACTTAATGAGTCACACGGTAAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAGTCCTTAACGACAGGAAGTGGCTCTTTGCTTTCATCAGCTGGGAGCATTACCTTTGATGATCGTAGTAAT
TTGCTCGTGATTCAAGATGAACCTCGTTCTGTGCAAAATATTAAAAAACTAATTGCTGAAATGGATAAACCTATTGAGCA
GATCGCTATTGAAGCGCGTATTGTGACAATTACGGACGAAAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACGGAAAATGCTGCGCGTGTAGCGGGCAGCTTATCCGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCTGCTGGCTCGATAGCATTACAAGTCGCGAAAATTAATGGTCGATTGCTCGATTTAGAATT
AAGCGCGTTAGAGCGTGAAAATAATGTGGAAATTATCGCAAGCCCTCGCTTACTAACCACAAATAAGAAAAGTGCAAGCA
TTAAACAGGGGACAGAAATTCCTTATATTGTGAGCAATACTCGTAACGATACGCAATCTGTGGAATTTCGCGAGGCGGTG
CTTGGTTTGGAAGTCACACCACATATTTCTAAAGATAACAATATTTTACTTGATTTATTAGTGAGCCAAAACTCACCAGG
TTCTCGTGTTTCTTATGGACAAAATGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTGCTTGGCGGCGTGTTTCACGACACAATTACGAAAAGCGAAGATAAGGTGCCATTGCTTGGCGATATA
CCCGTTATTAAACGATTATTCAGCAAAGAAAGCGAACGACATCAAAAACGTGAGTTAGTGATTTTTGTCACGCCGCATAT
TTTAAAAGCAGGAGAAACGTTAGAGGCGTTGAAGCAAAAAAGTGCGGGGAAAAAGTTACAATGA

Domains

Predicted by InterproScan.

• Bacterial type II/III secretion system short domain (Secretin_N) (123-187)

• Bacterial type II and III secretion system protein (Secretin) (269-429)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Haemophilus influenzae 86-028NP	96.404	99.553	0.96
comE	Haemophilus influenzae Rd KW20	96.18	99.553	0.957
comE	Glaesserella parasuis strain SC1401	52.706	95.078	0.501
pilQ	Vibrio campbellii strain DS40M4	42.959	93.736	0.403
pilQ	Vibrio cholerae O1 biovar El Tor strain E7946	42.233	92.17	0.389
pilQ	Vibrio cholerae strain A1552	42.233	92.17	0.389