Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   DV130_RS05190 Genome accession   NZ_CP031248
Coordinates   988512..989249 (-) Length   245 a.a.
NCBI ID   WP_001219120.1    Uniprot ID   Q9S1I6
Organism   Streptococcus pneumoniae strain M26365     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 983512..994249
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV130_RS05165 - 983834..985156 (+) 1323 WP_306341167.1 bacteriocin secretion accessory protein -
  DV130_RS05170 - 985222..986568 (+) 1347 WP_050072287.1 IS1380-like element ISSpn5 family transposase -
  DV130_RS05175 - 986762..986902 (+) 141 Protein_1006 bacteriocin ABC transporter ATP-binding protein -
  DV130_RS05180 blpC 986959..987114 (+) 156 WP_061450964.1 quorum-sensing system pheromone BlpC -
  DV130_RS05185 - 987158..988498 (-) 1341 WP_050073044.1 sensor histidine kinase -
  DV130_RS05190 comE/blpR 988512..989249 (-) 738 WP_001219120.1 LytTR family DNA-binding domain-containing protein Regulator
  DV130_RS05195 - 989254..989591 (-) 338 Protein_1010 LytTR family DNA-binding domain-containing protein -
  DV130_RS05200 - 989867..990196 (+) 330 WP_000132572.1 hypothetical protein -
  DV130_RS05205 - 990364..991413 (-) 1050 WP_050088109.1 ABC transporter permease -
  DV130_RS05210 pptA 991410..992141 (-) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  DV130_RS05215 - 992209..992619 (+) 411 WP_001278301.1 HIT family protein -
  DV130_RS05220 - 992629..992916 (+) 288 WP_000777760.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28754.98 Da        Isoelectric Point: 6.5884

>NTDB_id=304839 DV130_RS05190 WP_001219120.1 988512..989249(-) (comE/blpR) [Streptococcus pneumoniae strain M26365]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=304839 DV130_RS05190 WP_001219120.1 988512..989249(-) (comE/blpR) [Streptococcus pneumoniae strain M26365]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1I6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.017

98.776

0.376
  comE Streptococcus infantis strain Atu-4

35.887

100

0.363

Multiple sequence alignment