Detailed information NTG0303059

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: ETT49_RS02125
• Genome accession: NZ_CP035450
• Coordinates: 388290..390443 (-)
• Length: 717 a.a.
• NCBI ID: WP_020833322.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm93.4
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 383290..395443

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT49_RS02105 (ETT49_02105)	comE/blpR	384481..385230 (+)	750	WP_002992578.1	response regulator transcription factor	Regulator
ETT49_RS02110 (ETT49_02110)	-	385231..386565 (+)	1335	WP_014635339.1	sensor histidine kinase	-
ETT49_RS02115 (ETT49_02115)	-	386713..386838 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
ETT49_RS02120 (ETT49_02120)	-	386915..388279 (-)	1365	WP_014635340.1	bacteriocin secretion accessory protein	-
ETT49_RS02125 (ETT49_02125)	comA/nlmT	388290..390443 (-)	2154	WP_020833322.1	peptide cleavage/export ABC transporter	Regulator
ETT49_RS02135 (ETT49_02135)	-	390895..391581 (+)	687	Protein_360	transposase	-
ETT49_RS02140 (ETT49_02140)	-	391769..392014 (+)	246	WP_002994504.1	Blp family class II bacteriocin	-
ETT49_RS02145 (ETT49_02145)	-	392029..392211 (+)	183	WP_002987564.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ETT49_RS02150 (ETT49_02150)	-	392431..393117 (-)	687	Protein_363	transposase	-
ETT49_RS02155 (ETT49_02155)	-	393435..393662 (+)	228	WP_012560514.1	Blp family class II bacteriocin	-
ETT49_RS02160 (ETT49_02160)	-	393675..393875 (+)	201	WP_003060803.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ETT49_RS08625 (ETT49_02170)	-	394236..394364 (+)	129	WP_002985724.1	hypothetical protein	-
ETT49_RS02175 (ETT49_02175)	-	394414..394695 (+)	282	WP_011054252.1	hypothetical protein	-
ETT49_RS02180 (ETT49_02180)	-	394889..395289 (+)	401	Protein_368	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80543.45 Da
• Isoelectric Point: 7.0109

>NTDB_id=303059 ETT49_RS02125 WP_020833322.1 388290..390443(-) (comA/nlmT) [Streptococcus pyogenes strain emm93.4]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLINFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIETGSHQELMTKQGFYHHLFSG

Nucleotide

• Length: 2154 bp

>NTDB_id=303059 ETT49_RS02125 WP_020833322.1 388290..390443(-) (comA/nlmT) [Streptococcus pyogenes strain emm93.4]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGGTTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAACTTTTTACCTCTT
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAATTACCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACCAAACTTCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAATTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCGCTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAACAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTGGTTAA

Domains

Predicted by InterProScan.

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-649)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	73.007	99.721	0.728
comA	Streptococcus mitis NCTC 12261	67.651	99.163	0.671
comA	Streptococcus mitis SK321	67.229	99.163	0.667
comA	Streptococcus pneumoniae Rx1	67.229	99.163	0.667
comA	Streptococcus pneumoniae D39	67.229	99.163	0.667
comA	Streptococcus pneumoniae R6	67.229	99.163	0.667
comA	Streptococcus pneumoniae TIGR4	66.948	99.163	0.664
comA	Streptococcus gordonii str. Challis substr. CH1	66.154	99.721	0.66