Detailed information NTG0302370

Bioinformatically predicted

Overview

• Name: comX
• Type: Regulator
• Locus tag: DR994_RS06745
• Genome accession: NZ_CP030927
• Coordinates: 1308574..1309071 (-)
• Length: 165 a.a.
• NCBI ID: WP_002949220.1
• Uniprot ID: A0A0M4HKA9
• Organism: Streptococcus thermophilus strain CS9
• Function: activation of late competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1309825..1313610	1308574..1309071	flank	754

Gene organization within MGE regions

Location: 1308574..1313610

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DR994_RS06745 (DR994_06925)	comX	1308574..1309071 (-)	498	WP_002949220.1	sigma factor	Regulator
DR994_RS06750 (DR994_06930)	-	1309378..1309467 (-)	90	Protein_1299	IS200/IS605 family transposase	-
DR994_RS09685 (DR994_06935)	-	1309825..1310289 (+)	465	Protein_1300	transposase family protein	-
DR994_RS06760 (DR994_06940)	-	1310549..1311739 (-)	1191	WP_002949216.1	cyclopropane-fatty-acyl-phospholipid synthase family protein	-
DR994_RS06765 (DR994_06945)	-	1311821..1312147 (-)	327	WP_014607875.1	M20/M25/M40 family metallo-hydrolase	-
DR994_RS06770 (DR994_06950)	-	1312336..1312658 (+)	323	Protein_1303	transposase	-
DR994_RS06775 (DR994_06955)	-	1312743..1312964 (-)	222	WP_002948904.1	DUF4649 family protein	-

Sequence

Protein

• Length: 165 a.a.
• Molecular weight: 20160.12 Da
• Isoelectric Point: 5.2073

>NTDB_id=302370 DR994_RS06745 WP_002949220.1 1308574..1309071(-) (comX) [Streptococcus thermophilus strain CS9]
MEQEVFVKAYEKVRPIVLKAFRQYFIQLWDQADMEQEAMMTLYQLLKKFPDLEKDDDKLRRYFKTKFRNRLNDEVRRQES
VKRQANRQCYVEISDIAFCIPNKELDMVDRLAYDEQLNAFREQLSSEDSLKLDRLLGGECFRGRKKMIRELRFWMVDFDP
CNEED

Nucleotide

• Length: 498 bp

>NTDB_id=302370 DR994_RS06745 WP_002949220.1 1308574..1309071(-) (comX) [Streptococcus thermophilus strain CS9]
ATGGAACAAGAAGTTTTTGTTAAGGCATATGAAAAGGTAAGGCCAATTGTACTTAAGGCTTTTAGGCAATACTTTATTCA
GCTTTGGGATCAAGCTGACATGGAGCAAGAGGCGATGATGACTTTGTATCAGCTTTTAAAAAAGTTTCCTGATTTAGAGA
AAGATGATGATAAGTTACGTCGTTACTTTAAAACTAAGTTTAGGAATCGACTTAATGATGAAGTGAGGCGGCAGGAGTCA
GTAAAACGTCAAGCTAATAGACAGTGCTATGTTGAAATTTCAGATATTGCCTTTTGTATTCCCAATAAGGAGCTAGATAT
GGTTGATAGACTTGCTTATGATGAACAGCTTAATGCTTTTCGTGAGCAGTTATCATCGGAAGATTCTCTTAAGTTGGATC
GATTGTTGGGTGGTGAATGCTTTAGGGGAAGGAAAAAGATGATACGAGAGTTAAGATTTTGGATGGTTGACTTTGATCCA
TGTAATGAAGAAGACTGA

Domains

Predicted by InterproScan.

• Sigma-70 region 2 (Sigma70_r2) (10-79)

3D structure

• AlphaFold DB: A0A0M4HKA9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX	Streptococcus thermophilus LMD-9	100	100	1
comX	Streptococcus thermophilus LMG 18311	100	100	1
comX/sigX	Streptococcus salivarius strain HSISS4	89.091	100	0.891
comX	Streptococcus salivarius SK126	88.485	100	0.885
comX	Streptococcus sobrinus strain NIDR 6715-7	41.975	98.182	0.412
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	41.667	94.545	0.394
comX/sigX	Streptococcus mutans UA159	41.026	94.545	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX	Streptococcus suis D9	40.523	92.727	0.376
comX/sigX	Streptococcus suis isolate S10	40.523	92.727	0.376
comX/sigX	Streptococcus suis P1/7	40.523	92.727	0.376