Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DR994_RS05975 Genome accession   NZ_CP030927
Coordinates   1157910..1158599 (-) Length   229 a.a.
NCBI ID   WP_002949638.1    Uniprot ID   A0A060BFD8
Organism   Streptococcus thermophilus strain CS9     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1152910..1163599
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DR994_RS05955 (DR994_06120) dnaI 1153717..1154619 (-) 903 WP_002946786.1 primosomal protein DnaI -
  DR994_RS05960 (DR994_06125) - 1154623..1155798 (-) 1176 WP_002949643.1 DnaD domain protein -
  DR994_RS05965 (DR994_06130) nrdR 1155795..1156274 (-) 480 WP_002949642.1 transcriptional regulator NrdR -
  DR994_RS05970 (DR994_06135) covS 1156396..1157913 (-) 1518 WP_173940561.1 HAMP domain-containing histidine kinase Regulator
  DR994_RS05975 (DR994_06140) covR 1157910..1158599 (-) 690 WP_002949638.1 response regulator transcription factor Regulator
  DR994_RS05980 (DR994_06145) - 1158755..1159291 (-) 537 WP_173940562.1 YceD family protein -
  DR994_RS05985 (DR994_06150) rsmG 1159588..1160301 (+) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DR994_RS05990 (DR994_06155) - 1160371..1161735 (+) 1365 WP_275946675.1 potassium transporter TrkG -
  DR994_RS05995 (DR994_06160) - 1161775..1162446 (+) 672 WP_002946492.1 TrkA family potassium uptake protein -
  DR994_RS10020 (DR994_06165) - 1162463..1162633 (-) 171 Protein_1149 ascorbate 6-phosphate lactonase -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26655.77 Da        Isoelectric Point: 4.7059

>NTDB_id=302362 DR994_RS05975 WP_002949638.1 1157910..1158599(-) (covR) [Streptococcus thermophilus strain CS9]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=302362 DR994_RS05975 WP_002949638.1 1157910..1158599(-) (covR) [Streptococcus thermophilus strain CS9]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACCTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

96.07

100

0.961
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441

Multiple sequence alignment