Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   ETT61_RS01815 Genome accession   NZ_CP035438
Coordinates   321654..322415 (+) Length   253 a.a.
NCBI ID   WP_002986029.1    Uniprot ID   A2RCI9
Organism   Streptococcus pyogenes strain emm22.8     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 316654..327415
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT61_RS01800 (ETT61_01800) - 316912..318480 (-) 1569 WP_136020502.1 ABC transporter substrate-binding protein/permease -
  ETT61_RS01805 (ETT61_01805) - 318678..320603 (+) 1926 WP_136020503.1 DUF2207 domain-containing protein -
  ETT61_RS01810 (ETT61_01810) - 320669..321508 (+) 840 WP_136020504.1 undecaprenyl-diphosphate phosphatase -
  ETT61_RS01815 (ETT61_01815) mecA 321654..322415 (+) 762 WP_002986029.1 adaptor protein MecA Regulator
  ETT61_RS01820 (ETT61_01820) - 322422..323591 (+) 1170 WP_136020505.1 glycosyltransferase family 4 protein -
  ETT61_RS01825 (ETT61_01825) sufC 323714..324484 (+) 771 WP_136020506.1 Fe-S cluster assembly ATPase SufC -
  ETT61_RS01830 (ETT61_01830) sufD 324579..325841 (+) 1263 WP_047235146.1 Fe-S cluster assembly protein SufD -
  ETT61_RS01835 (ETT61_01835) - 325872..327098 (+) 1227 WP_136020507.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29051.72 Da        Isoelectric Point: 4.1622

>NTDB_id=301906 ETT61_RS01815 WP_002986029.1 321654..322415(+) (mecA) [Streptococcus pyogenes strain emm22.8]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=301906 ETT61_RS01815 WP_002986029.1 321654..322415(+) (mecA) [Streptococcus pyogenes strain emm22.8]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAAGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTAGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCTACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterProScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A2RCI9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.235

100

0.486
  mecA Streptococcus pneumoniae D39

48.235

100

0.486
  mecA Streptococcus pneumoniae R6

48.235

100

0.486
  mecA Streptococcus pneumoniae TIGR4

48.235

100

0.486