Detailed information NTG0301571

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: ETT65_RS04920
• Genome accession: NZ_CP035434
• Coordinates: 944021..946174 (+)
• Length: 717 a.a.
• NCBI ID: WP_136075800.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm75.1
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 939021..951174

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT65_RS04890 (ETT65_04890)	-	939200..939823 (-)	624	WP_136075805.1	CPBP family intramembrane glutamic endopeptidase	-
ETT65_RS04895 (ETT65_04895)	-	939900..940559 (-)	660	WP_136075804.1	hypothetical protein	-
ETT65_RS04900 (ETT65_04900)	-	940573..940826 (-)	254	Protein_892	Blp family class II bacteriocin	-
ETT65_RS04905 (ETT65_04905)	-	941413..942579 (-)	1167	WP_136075803.1	hypothetical protein	-
ETT65_RS04910 (ETT65_04910)	-	942576..943439 (-)	864	WP_136075802.1	ABC transporter ATP-binding protein	-
ETT65_RS04915 (ETT65_04915)	-	943522..943719 (-)	198	WP_136075801.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
ETT65_RS04920 (ETT65_04920)	comA/nlmT	944021..946174 (+)	2154	WP_136075800.1	peptide cleavage/export ABC transporter	Regulator
ETT65_RS04925 (ETT65_04925)	comB	946186..947547 (+)	1362	WP_136075799.1	bacteriocin secretion accessory protein	Regulator
ETT65_RS04930 (ETT65_04930)	-	947645..947800 (+)	156	WP_136075798.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
ETT65_RS04935 (ETT65_04935)	-	947849..949192 (-)	1344	WP_136075797.1	GHKL domain-containing protein	-
ETT65_RS04940 (ETT65_04940)	comE/blpR	949206..949943 (-)	738	WP_136075796.1	response regulator transcription factor	Regulator
ETT65_RS04945 (ETT65_04945)	-	949945..950286 (-)	342	WP_227877714.1	LytTR family DNA-binding domain-containing protein	-
ETT65_RS09680	-	950485..950880 (+)	396	WP_227877846.1	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80672.62 Da
• Isoelectric Point: 7.6433

>NTDB_id=301571 ETT65_RS04920 WP_136075800.1 944021..946174(+) (comA/nlmT) [Streptococcus pyogenes strain emm75.1]
MTAYKRTFVPQIDARDCGVAALASIAKFYGSNYSLAHLRELAKTNKEGTTALGIVKAAKEMGFETRAIQADMSLFDMDDV
PYPFIVHVTKEGKLQHYYVVYHNKKDHLIIGDPDPTVKVTKMTKERFASEWTSVAIFLAPEPSYKPHKDKKNGLMSFLPL
IFRQRSLIFYIVLASLLVTLINIGGSYYLQGILDEYIPNQMKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEVISRFTDANSIIDALASTILSLFLDVSILTIVGSVLLVQNTNLFLLSLVSVPIYII
IIFAFMKPFEKMNNDVMQSNSMVSSAIIEDISGIETIKSLTSEESRYQKIDSEFVDYLDKSFKLSKYSILQTTLKQGAQL
ILNIVILWFGAQLVMNGHISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVESEFRNSQTLTDSQFL
TGDIRFEDLSYKYGFGRDTLSDINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYKGRITINNNDLKLVDKKTLRQHI
NYLPQQAYIFSGSILENLTLGANQMISQEDIIRACEIAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVIDNLMAMTDKTIIFVAHRLSISERTNQVIVLDQGKVIETGSHHELMTKQGFYHHLFSK

Nucleotide

• Length: 2154 bp

>NTDB_id=301571 ETT65_RS04920 WP_136075800.1 944021..946174(+) (comA/nlmT) [Streptococcus pyogenes strain emm75.1]
ATGACAGCTTACAAACGAACCTTTGTTCCTCAAATCGATGCCAGAGACTGTGGTGTGGCTGCTTTAGCCTCTATTGCTAA
GTTCTATGGCTCCAATTACTCTTTAGCCCATTTGAGGGAATTAGCTAAAACGAATAAAGAAGGAACGACCGCTCTTGGTA
TCGTCAAGGCAGCCAAAGAAATGGGCTTTGAAACCAGAGCCATACAGGCGGATATGAGTCTCTTTGATATGGATGACGTT
CCCTATCCCTTCATCGTTCACGTCACTAAAGAAGGCAAACTGCAACACTACTATGTGGTCTATCATAACAAAAAAGACCA
CCTCATCATTGGTGATCCTGACCCTACGGTCAAAGTCACCAAGATGACCAAGGAGCGGTTTGCTTCTGAATGGACAAGCG
TCGCCATCTTTCTGGCTCCAGAACCCAGCTATAAGCCTCACAAGGATAAAAAGAACGGCCTGATGAGCTTTCTCCCCTTG
ATTTTCAGGCAACGTTCTCTTATCTTTTATATCGTCTTGGCTAGTCTTCTAGTGACACTTATCAATATTGGTGGTTCTTA
CTACCTGCAAGGGATTTTGGATGAATACATCCCTAATCAGATGAAGTCAACCTTAGGTATTATCTCCATCGGTCTCATCA
TCACCTACATCCTCCAGCAGATGATGAGTTTCTCACGGGATTACCTCTTGACCGTGCTCAGCCAGCGGCTAAGTATTGAT
GTGATTCTCTCCTATATCCGCCACATCTTTGAACTGCCTATGTCCTTCTTTGCGACACGGCGGACTGGCGAGGTCATCTC
TCGCTTTACAGATGCCAATTCGATCATTGATGCTCTGGCTTCGACCATTTTGTCACTCTTCCTTGATGTTTCCATCTTGA
CCATTGTTGGTAGTGTACTTTTGGTACAAAACACCAACCTTTTCCTTCTCTCTCTGGTCTCAGTTCCCATTTATATCATT
ATTATTTTTGCTTTTATGAAGCCGTTTGAGAAGATGAATAACGATGTTATGCAGAGCAATTCCATGGTCAGCTCTGCCAT
TATCGAAGACATCAGCGGCATTGAAACCATCAAATCCTTGACCAGCGAAGAAAGCCGCTACCAGAAGATTGATAGCGAAT
TCGTAGATTACCTGGACAAATCCTTCAAACTCAGTAAATACTCTATCCTTCAAACCACCCTTAAACAGGGGGCTCAGCTC
ATTCTAAATATTGTCATCTTGTGGTTTGGGGCTCAGCTAGTCATGAACGGACACATTTCTGTTGGACAACTGATTACCTT
CAACACCCTTCTATCTTATTTTACCAATCCTTTAGAAAATATTATCAACCTCCAAACCAAGCTCCAGTCTGCCAAGGTGG
CTAACAATCGCCTAAATGAAGTCTACTTAGTTGAATCTGAATTCAGAAACAGTCAGACCTTAACCGATTCACAGTTCCTG
ACTGGCGATATTCGCTTTGAAGACCTTTCCTATAAGTACGGTTTTGGACGTGACACCCTATCTGATATCAATCTGACCAT
CAAACAAGGCGATAAGGTCAGTCTAGTGGGGATTAGCGGCTCAGGAAAGACAACCTTGGCCAAGATGATTGTCAACTTCT
TTGAGCCTTACAAGGGCCGAATCACCATCAACAACAACGATCTTAAACTGGTTGATAAAAAGACGTTACGACAGCACATC
AACTACCTCCCCCAACAAGCTTATATTTTTAGTGGCTCGATCTTAGAAAACCTAACTTTGGGAGCTAATCAAATGATTAG
CCAAGAAGATATTATCAGGGCTTGTGAGATCGCTGAAATTCGCCAAGATATCGAACAAATGCCCATGGGTTATCAAACAG
AATTGTCCGATGGGGCAGGCTTATCAGGTGGGCAAAAACAACGGATTGCTTTGGCTAGGGCTCTCCTTACTAAAGCCCCT
GTTCTTATTCTTGATGAAGCCACCAGTGGTCTTGATGTTTTAACGGAAAAAAAGGTCATTGATAATCTGATGGCCATGAC
AGATAAGACCATTATCTTTGTCGCACACCGCCTCAGTATTTCTGAACGAACCAATCAAGTTATCGTTCTTGACCAAGGGA
AGGTCATTGAGACTGGTTCACATCACGAATTAATGACCAAACAAGGTTTCTACCATCATCTATTTAGCAAGTAA

Domains

Predicted by InterProScan.

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-649)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	73.566	99.721	0.734
comA	Streptococcus mitis NCTC 12261	68.073	99.163	0.675
comA	Streptococcus mitis SK321	67.511	99.163	0.669
comA	Streptococcus pneumoniae Rx1	67.37	99.163	0.668
comA	Streptococcus pneumoniae D39	67.37	99.163	0.668
comA	Streptococcus pneumoniae R6	67.37	99.163	0.668
comA	Streptococcus pneumoniae TIGR4	67.089	99.163	0.665
comA	Streptococcus gordonii str. Challis substr. CH1	65.455	99.721	0.653