Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ETA57_RS22750 Genome accession   NZ_CP035404
Coordinates   4376010..4377221 (-) Length   403 a.a.
NCBI ID   WP_011198492.1    Uniprot ID   Q65CS2
Organism   Bacillus licheniformis strain SRCM103583     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 4371010..4382221
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETA57_RS22720 (ETA57_22720) rlmH 4371762..4372241 (-) 480 WP_003177946.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ETA57_RS22725 (ETA57_22725) - 4372322..4372480 (-) 159 WP_003177948.1 CxxH/CxxC protein -
  ETA57_RS22730 (ETA57_22730) - 4372679..4373161 (-) 483 WP_009330015.1 DUF4234 domain-containing protein -
  ETA57_RS22735 (ETA57_22735) - 4373592..4374110 (-) 519 WP_011201784.1 GNAT family N-acetyltransferase -
  ETA57_RS22740 (ETA57_22740) - 4374141..4374611 (-) 471 WP_003177954.1 membrane protein -
  ETA57_RS22745 (ETA57_22745) - 4374868..4375713 (-) 846 WP_011198491.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
  ETA57_RS22750 (ETA57_22750) htrA 4376010..4377221 (-) 1212 WP_011198492.1 S1C family serine protease Regulator
  ETA57_RS22755 (ETA57_22755) vicX 4377304..4378098 (-) 795 WP_003177960.1 MBL fold metallo-hydrolase Regulator
  ETA57_RS22760 (ETA57_22760) yycI 4378113..4378961 (-) 849 WP_021837842.1 two-component system regulatory protein YycI -
  ETA57_RS22765 (ETA57_22765) yycH 4378948..4380312 (-) 1365 WP_129093988.1 two-component system activity regulator YycH -
  ETA57_RS22770 (ETA57_22770) walK 4380302..4382146 (-) 1845 WP_003177965.1 cell wall metabolism sensor histidine kinase WalK -

Sequence

Protein


Download         Length: 403 a.a.        Molecular weight: 43123.96 Da        Isoelectric Point: 5.7694

>NTDB_id=300003 ETA57_RS22750 WP_011198492.1 4376010..4377221(-) (htrA) [Bacillus licheniformis strain SRCM103583]
MEFNHDEEKFVREKPVRSWRSFLFSSLVGAVIGALLTVFALPYLSQQGWLPYNLQVIEARGGQGAQQGGTVRNVSVNVNN
EVTQMVSKVSDSVVGVINIQKTGVWDGDSEAGTGSGVIYKKDGNTSHIVTNHHVIEGASQIEISLNDGTRIPAKLIGSDK
LMDLAVLQVNSNKIKAAAEFGDSDKVKTGEPVIAIGNPLGLQFSGSVTQGIISGTERAVPVDSNGDGQPDWNAEVLQTDA
AINPGNSGGGLFNIDGKVIGINSMKIAESAVEGIGLSIPANLAIPVIEDLETYGEVRRPYLGIEMKSLGDIASYHWQETL
KLPKNVTSGVVVMGVQPVSPAGRAGLKELDVIVEFNGDRVYDIVDLRKKLYTKNVGDKVKIKYLRGGKEKTTEVKLTRSQ
LGS

Nucleotide


Download         Length: 1212 bp        

>NTDB_id=300003 ETA57_RS22750 WP_011198492.1 4376010..4377221(-) (htrA) [Bacillus licheniformis strain SRCM103583]
GTGGAGTTTAATCATGATGAGGAAAAATTCGTTCGGGAAAAGCCGGTGAGAAGTTGGAGAAGCTTTTTGTTTTCAAGCCT
GGTCGGCGCCGTCATCGGCGCTCTTTTAACAGTGTTTGCCTTGCCGTATCTCTCGCAGCAGGGATGGCTGCCGTATAATC
TGCAAGTCATCGAAGCGCGCGGCGGCCAAGGAGCACAGCAGGGCGGGACGGTCCGCAATGTATCCGTCAACGTGAATAAT
GAAGTCACGCAAATGGTCTCTAAGGTTTCTGATTCTGTTGTCGGCGTTATCAACATCCAAAAGACAGGTGTATGGGATGG
TGACAGCGAAGCGGGAACAGGCTCGGGCGTTATTTATAAAAAGGACGGCAACACATCCCACATTGTGACAAACCACCATG
TCATTGAAGGGGCGTCCCAAATAGAAATCAGCCTGAATGACGGAACACGGATTCCGGCAAAACTGATCGGCAGCGATAAG
CTGATGGATCTGGCCGTCCTGCAAGTCAACAGCAACAAAATAAAAGCAGCTGCCGAATTTGGAGATTCTGATAAAGTGAA
GACAGGCGAGCCTGTCATCGCGATTGGAAACCCGCTCGGCCTGCAGTTTTCAGGCTCTGTTACACAAGGAATCATCTCAG
GAACCGAACGCGCTGTGCCGGTCGATTCCAACGGAGACGGACAGCCGGACTGGAACGCCGAAGTACTGCAGACGGATGCT
GCCATTAACCCGGGTAACAGCGGAGGCGGGCTGTTTAATATTGATGGAAAAGTCATCGGCATTAATTCGATGAAAATCGC
TGAATCAGCCGTCGAAGGCATCGGTCTGAGCATTCCGGCCAACCTTGCCATTCCGGTTATCGAAGATTTGGAAACGTACG
GTGAAGTGAGACGGCCGTATCTCGGAATTGAGATGAAATCACTTGGCGATATCGCAAGCTACCACTGGCAGGAAACGCTT
AAACTGCCGAAAAACGTAACATCAGGCGTAGTTGTGATGGGTGTTCAGCCGGTATCTCCTGCAGGCAGAGCCGGTCTGAA
AGAGCTCGATGTCATCGTCGAATTTAACGGTGACCGTGTTTACGATATCGTTGATCTGCGTAAAAAGCTTTACACCAAAA
ACGTCGGCGACAAGGTAAAAATCAAATACCTGCGGGGCGGAAAAGAAAAGACAACAGAAGTAAAGCTGACCCGATCCCAA
TTAGGAAGCTGA

Domains

Predicted by InterProScan.

PDZ domain (PDZ_2)

(299-396)

Peptidase family M50 (Peptidase_M50)

(239-398)

Trypsin-like peptidase domain (Trypsin_2)

(114-261)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q65CS2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

43.799

94.045

0.412
  htrA Streptococcus mutans UA159

45.17

87.345

0.395
  htrA Streptococcus pneumoniae D39

46.847

82.63

0.387
  htrA Streptococcus pneumoniae TIGR4

46.847

82.63

0.387
  htrA Streptococcus pneumoniae R6

46.847

82.63

0.387
  htrA Streptococcus pneumoniae Rx1

46.847

82.63

0.387
  htrA Streptococcus gordonii str. Challis substr. CH1

42.693

86.6

0.37