Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   SPH_RS03085 Genome accession   NC_010380
Coordinates   588192..590345 (-) Length   717 a.a.
NCBI ID   WP_000205158.1    Uniprot ID   B1IA64
Organism   Streptococcus pneumoniae Hungary19A-6     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 583192..595345
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPH_RS03055 (SPH_0630) - 583527..583856 (-) 330 WP_000132572.1 hypothetical protein -
  SPH_RS03060 (SPH_0631) - 584132..584470 (+) 339 WP_000876676.1 LytTR family DNA-binding domain-containing protein -
  SPH_RS03065 (SPH_0632) comE/blpR 584475..585212 (+) 738 WP_001219147.1 response regulator transcription factor Regulator
  SPH_RS03070 (SPH_0633) - 585226..586566 (+) 1341 WP_001028044.1 sensor histidine kinase -
  SPH_RS03075 (SPH_0634) blpC 586608..586763 (-) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  SPH_RS03080 (SPH_0635) - 586820..588181 (-) 1362 WP_001069098.1 bacteriocin secretion accessory protein -
  SPH_RS03085 (SPH_0636) comA/nlmT 588192..590345 (-) 2154 WP_000205158.1 peptide cleavage/export ABC transporter BlpA Regulator
  SPH_RS03090 (SPH_0637) blpI 590627..590824 (+) 198 WP_001093261.1 bacteriocin-like peptide BlpI -
  SPH_RS03095 (SPH_0638) blpJ 591291..591560 (+) 270 WP_001093248.1 bacteriocin-like peptide BlpJ -
  SPH_RS03100 (SPH_0639) blpU 591629..591859 (+) 231 WP_000379967.1 bacteriocin-like peptide BlpU -
  SPH_RS03105 (SPH_0640) - 591862..591981 (+) 120 WP_000346298.1 PncF family bacteriocin immunity protein -
  SPH_RS12305 (SPH_0641) - 592278..592442 (+) 165 WP_000727118.1 hypothetical protein -
  SPH_RS03120 (SPH_0642) - 592439..592842 (+) 404 Protein_603 immunity protein -
  SPH_RS03125 (SPH_0643) - 592925..593308 (+) 384 WP_000877378.1 hypothetical protein -
  SPH_RS03130 (SPH_0644) - 593360..594049 (+) 690 WP_000760541.1 CPBP family intramembrane glutamic endopeptidase -
  SPH_RS03135 (SPH_0645) blpZ 594091..594324 (+) 234 WP_000276498.1 immunity protein BlpZ -
  SPH_RS03140 (SPH_0646) - 594475..595086 (+) 612 WP_000394045.1 type II CAAX endopeptidase family protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80738.74 Da        Isoelectric Point: 7.6796

>NTDB_id=30000 SPH_RS03085 WP_000205158.1 588192..590345(-) (comA/nlmT) [Streptococcus pneumoniae Hungary19A-6]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLLSIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTKL
VLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQSPENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNHMISQEDILKACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVIDNLISLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=30000 SPH_RS03085 WP_000205158.1 588192..590345(-) (comA/nlmT) [Streptococcus pneumoniae Hungary19A-6]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATCGGTGGTTCTTA
CTATCTCCAAGGAATCTTGGATGAATACATTCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGGTTA
TCACCTATATCCTCCAACAAGTCATGAGCTTCTCCAGAGATTATCTCCTAACCGTTCTGAGCCAGAGATTAAGCATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCCATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTTCTGGATGTTTCTATTCTGA
TTCTTGTAGGGGGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTCCTTTCTCTTCTTTCCATTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAACCTTTTGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTGGAAAAATCCTTTAAGCTCAGTAAATATTCTATTTTACAAACGAGTTTAAAGCAGGGAACAAAATTA
GTTCTGAATATCCTTATCCTATGGTTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTACCTT
TAACACACTTTTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTTG
CTAATAACCGTTTGAACGAAGTCTATCTAGTCGAGTCTGAGTTCCAATCCCCAGAAAACCCTGTTCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TTGAACCCTACAAAGGGCATATTTCCATCAATCATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCCCAACAAGCCTATATCTTTAATGGCTCTATTTTGGAAAACTTAACCTTGGGCGGTAATCATATGATTAG
CCAAGAAGATATTCTAAAAGCTTGTGAATTAGCTGAAATTCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAAAAGCAACGAATCGCTCTCGCTCGTGCTCTTTTAACTAAAGCTCCT
GTTTTAATACTAGATGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAGGTTATAGATAATCTTATATCCCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACTAACCGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGTAGTCACCAAGAGTTAATGCAGGCGCAAGGTTTCTACCATCATCTATTCAATAAATAA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-438)

ABC transporter (ABC_tran)

(500-649)

Peptidase C39 family (Peptidase_C39)

(7-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B1IA64

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

72.028

99.721

0.718
  comA Streptococcus mitis NCTC 12261

66.48

99.442

0.661
  comA Streptococcus pneumoniae Rx1

66.199

99.442

0.658
  comA Streptococcus pneumoniae D39

66.199

99.442

0.658
  comA Streptococcus pneumoniae R6

66.199

99.442

0.658
  comA Streptococcus mitis SK321

65.919

99.442

0.656
  comA Streptococcus pneumoniae TIGR4

65.919

99.442

0.656
  comA Streptococcus gordonii str. Challis substr. CH1

65.181

100

0.653

Multiple sequence alignment