Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   SPH_RS00715 Genome accession   NC_010380
Coordinates   122228..123577 (+) Length   449 a.a.
NCBI ID   WP_000801627.1    Uniprot ID   A0AAJ5TLL7
Organism   Streptococcus pneumoniae Hungary19A-6     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 117228..128577
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPH_RS12055 - 118135..118617 (+) 483 WP_001232094.1 stage II sporulation protein M -
  SPH_RS00695 (SPH_0146) - 118614..119210 (+) 597 WP_000687787.1 ATP-binding cassette domain-containing protein -
  SPH_RS00700 (SPH_0147) - 119191..119682 (+) 492 WP_000671990.1 hypothetical protein -
  SPH_RS00710 (SPH_0148) comA 120062..122215 (+) 2154 WP_000668283.1 peptide cleavage/export ABC transporter ComA Regulator
  SPH_RS00715 (SPH_0149) comB 122228..123577 (+) 1350 WP_000801627.1 competence pheromone export protein ComB Regulator
  SPH_RS00720 (SPH_0150) purC 123746..124453 (+) 708 WP_000043300.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  SPH_RS14285 (SPH_0151) - 124464..124598 (+) 135 WP_000429436.1 hypothetical protein -
  SPH_RS00730 (SPH_0152) - 124655..128380 (+) 3726 WP_000361191.1 phosphoribosylformylglycinamidine synthase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 49635.59 Da        Isoelectric Point: 5.3895

>NTDB_id=29992 SPH_RS00715 WP_000801627.1 122228..123577(+) (comB) [Streptococcus pneumoniae Hungary19A-6]
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQVGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTVKSAIETGASLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAEINLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=29992 SPH_RS00715 WP_000801627.1 122228..123577(+) (comB) [Streptococcus pneumoniae Hungary19A-6]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAAAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGTAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGTTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCAAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCCTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTTCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGATTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
TCTACAGATGATTACGGGCAAGAAAAGTTATCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA

Domains

Predicted by InterproScan.

HlyD family secretion protein (HlyD_3)

(310-423)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus pneumoniae TIGR4

98.886

100

0.989
  comB Streptococcus pneumoniae D39

98.664

100

0.987
  comB Streptococcus pneumoniae R6

98.664

100

0.987
  comB Streptococcus pneumoniae Rx1

98.664

100

0.987
  comB Streptococcus mitis SK321

94.432

100

0.944
  comB Streptococcus mitis NCTC 12261

93.987

100

0.94
  comB Streptococcus gordonii str. Challis substr. CH1

55.778

100

0.559

Multiple sequence alignment