Detailed information
Bioinformatically predicted
Overview
| Name | htrA | Type | Regulator |
| Locus tag | DK877_RS11020 | Genome accession | NZ_CP030023 |
| Coordinates | 2220320..2221516 (+) | Length | 398 a.a. |
| NCBI ID | WP_009911075.1 | Uniprot ID | G7SHV4 |
| Organism | Streptococcus suis strain ISU2414 | ||
| Function | require for competence development (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 2173715..2222341 | 2220320..2221516 | within | 0 |
Gene organization within MGE regions
Location: 2173715..2222341
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DK877_RS10760 (DK877_11110) | - | 2173715..2174164 (-) | 450 | WP_002936148.1 | thiol reductase thioredoxin | - |
| DK877_RS10765 (DK877_11115) | rpsD | 2174231..2174842 (-) | 612 | WP_002938227.1 | 30S ribosomal protein S4 | - |
| DK877_RS10770 (DK877_11120) | - | 2175053..2175304 (-) | 252 | WP_002938218.1 | Veg family protein | - |
| DK877_RS10775 (DK877_11125) | dnaB | 2175308..2176663 (-) | 1356 | WP_002938217.1 | replicative DNA helicase | - |
| DK877_RS10780 (DK877_11130) | rplI | 2176695..2177147 (-) | 453 | WP_002938216.1 | 50S ribosomal protein L9 | - |
| DK877_RS10785 (DK877_11135) | - | 2177158..2179119 (-) | 1962 | WP_002938215.1 | DHH family phosphoesterase | - |
| DK877_RS10790 (DK877_11140) | mnmG | 2179226..2181142 (-) | 1917 | WP_002938214.1 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG | - |
| DK877_RS10795 (DK877_11145) | - | 2181139..2181600 (-) | 462 | WP_002938211.1 | NUDIX hydrolase | - |
| DK877_RS10800 (DK877_11150) | - | 2181742..2182068 (-) | 327 | WP_002938209.1 | helix-turn-helix domain-containing protein | - |
| DK877_RS10805 (DK877_11155) | - | 2182194..2182583 (+) | 390 | WP_002938206.1 | nuclear transport factor 2 family protein | - |
| DK877_RS10810 (DK877_11160) | mnmA | 2182626..2183750 (-) | 1125 | WP_022540729.1 | tRNA 2-thiouridine(34) synthase MnmA | - |
| DK877_RS10815 (DK877_11165) | sdaAB | 2183965..2184636 (+) | 672 | WP_002938202.1 | L-serine ammonia-lyase, iron-sulfur-dependent subunit beta | - |
| DK877_RS10820 (DK877_11170) | sdaAA | 2184649..2185521 (+) | 873 | WP_002938200.1 | L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha | - |
| DK877_RS10825 (DK877_11175) | - | 2185978..2186532 (-) | 555 | WP_009911037.1 | LysM domain-containing protein | - |
| DK877_RS10830 (DK877_11180) | - | 2186664..2187458 (-) | 795 | WP_002938197.1 | energy-coupling factor transporter transmembrane protein EcfT | - |
| DK877_RS10835 (DK877_11185) | - | 2187451..2188293 (-) | 843 | WP_053863329.1 | energy-coupling factor transporter ATPase | - |
| DK877_RS10840 (DK877_11190) | - | 2188269..2189105 (-) | 837 | WP_002938187.1 | energy-coupling factor ABC transporter ATP-binding protein | - |
| DK877_RS10845 (DK877_11195) | pgsA | 2189102..2189641 (-) | 540 | WP_013730677.1 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase | - |
| DK877_RS10850 (DK877_11200) | rodZ | 2189651..2190508 (-) | 858 | WP_002939074.1 | cytoskeleton protein RodZ | - |
| DK877_RS10855 (DK877_11205) | yfmH | 2190590..2191873 (-) | 1284 | WP_002939071.1 | EF-P 5-aminopentanol modification-associated protein YfmH | - |
| DK877_RS10860 (DK877_11210) | yfmF | 2191870..2193123 (-) | 1254 | WP_009911054.1 | EF-P 5-aminopentanol modification-associated protein YfmF | - |
| DK877_RS10865 (DK877_11220) | - | 2193546..2194748 (+) | 1203 | WP_009909264.1 | IS110-like element ISSsu7 family transposase | - |
| DK877_RS10870 (DK877_11225) | - | 2195164..2195505 (-) | 342 | WP_024381289.1 | DUF1492 domain-containing protein | - |
| DK877_RS10875 (DK877_11230) | - | 2195811..2197013 (-) | 1203 | WP_009909264.1 | IS110-like element ISSsu7 family transposase | - |
| DK877_RS11265 | - | 2197351..2197503 (-) | 153 | WP_226314305.1 | hypothetical protein | - |
| DK877_RS11270 | - | 2197539..2197742 (-) | 204 | WP_226314306.1 | hypothetical protein | - |
| DK877_RS10885 (DK877_11240) | - | 2197792..2198340 (-) | 549 | WP_013730680.1 | hypothetical protein | - |
| DK877_RS10890 (DK877_11245) | - | 2198418..2198876 (-) | 459 | WP_013730681.1 | hypothetical protein | - |
| DK877_RS10895 (DK877_11250) | - | 2198889..2199704 (-) | 816 | WP_013730682.1 | DnaD domain protein | - |
| DK877_RS10900 (DK877_11255) | - | 2199691..2199975 (-) | 285 | WP_013730683.1 | hypothetical protein | - |
| DK877_RS10905 (DK877_11260) | - | 2199965..2200303 (-) | 339 | WP_024409270.1 | hypothetical protein | - |
| DK877_RS10910 | - | 2200300..2200449 (-) | 150 | WP_013730685.1 | hypothetical protein | - |
| DK877_RS10915 (DK877_11265) | - | 2200461..2200664 (-) | 204 | WP_013730686.1 | hypothetical protein | - |
| DK877_RS10920 (DK877_11270) | - | 2200652..2201041 (-) | 390 | WP_013730687.1 | hypothetical protein | - |
| DK877_RS10925 (DK877_11275) | - | 2201480..2202106 (-) | 627 | WP_013730688.1 | Rha family transcriptional regulator | - |
| DK877_RS10930 (DK877_11280) | - | 2202119..2202865 (-) | 747 | WP_013730689.1 | Bro-N domain-containing protein | - |
| DK877_RS10935 (DK877_11285) | - | 2202884..2203111 (-) | 228 | WP_013730690.1 | helix-turn-helix domain-containing protein | - |
| DK877_RS10940 (DK877_11290) | - | 2203265..2203978 (+) | 714 | WP_013730691.1 | helix-turn-helix domain-containing protein | - |
| DK877_RS10945 (DK877_11295) | - | 2204342..2205172 (+) | 831 | WP_013730692.1 | KilA-N domain-containing protein | - |
| DK877_RS10950 (DK877_11300) | - | 2205337..2206509 (+) | 1173 | WP_013730693.1 | site-specific integrase | - |
| DK877_RS10955 (DK877_11305) | yaaA | 2206647..2207030 (+) | 384 | WP_002936175.1 | S4 domain-containing protein YaaA | - |
| DK877_RS10960 (DK877_11310) | recF | 2207033..2208127 (+) | 1095 | WP_002936177.1 | DNA replication/repair protein RecF | - |
| DK877_RS10965 (DK877_11315) | - | 2208567..2209769 (-) | 1203 | WP_009909264.1 | IS110-like element ISSsu7 family transposase | - |
| DK877_RS10970 (DK877_11320) | guaB | 2210020..2211501 (-) | 1482 | WP_014637236.1 | IMP dehydrogenase | - |
| DK877_RS10975 (DK877_11325) | trpS | 2211733..2212758 (-) | 1026 | WP_013730696.1 | tryptophan--tRNA ligase | - |
| DK877_RS10980 (DK877_11330) | - | 2213113..2213985 (+) | 873 | WP_013730698.1 | YitT family protein | - |
| DK877_RS10985 (DK877_11335) | - | 2214050..2215672 (+) | 1623 | WP_004194522.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| DK877_RS10990 (DK877_11340) | - | 2215979..2218558 (+) | 2580 | WP_004194524.1 | YfhO family protein | - |
| DK877_RS11010 (DK877_11360) | - | 2218959..2219642 (-) | 684 | WP_004194526.1 | YoaK family protein | - |
| DK877_RS11015 (DK877_11365) | rlmH | 2219667..2220146 (-) | 480 | WP_004194528.1 | 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH | - |
| DK877_RS11020 (DK877_11370) | htrA | 2220320..2221516 (+) | 1197 | WP_009911075.1 | S1C family serine protease | Regulator |
| DK877_RS11025 (DK877_11375) | spo0J | 2221577..2222341 (+) | 765 | WP_004194534.1 | ParB/RepB/Spo0J family partition protein | Regulator |
Sequence
Protein
Download Length: 398 a.a. Molecular weight: 41818.83 Da Isoelectric Point: 4.6655
>NTDB_id=298505 DK877_RS11020 WP_009911075.1 2220320..2221516(+) (htrA) [Streptococcus suis strain ISU2414]
MERIPYMKKYLKFAILFVIGFFGGLIGALSASFFQPRVQQANSAITSVSNVQYNNETSTTKAVEKVQNAVVSVINYQKSA
NNSLGAIFGNIESSDELAVAGEGSGVIYKKDGQYAYIVTNTHVINNAEKIDILLASGEKISGELVGSDTYSDIAVIKISA
DKVTAVAEFADSDTIKVGETAIAIGSPLGSVYANTVTQGIISSLSRTVTSQSKDGQTISTNAIQTDTAINPGNSGGPLIN
TQGQVIGITSSKITSSSANSSGVAVEGLGFAIPANDAVAIINQLEKTGQVSRPALGVHMVNLTTLSTSQLEKAGLSNTEL
TSGVVIVSTQSGLPADGKLETFDVITEIDGEAIQNKSDLQSALYKHQIGDTITVTYYRNNQKQTVDIKLTHSTEELSE
MERIPYMKKYLKFAILFVIGFFGGLIGALSASFFQPRVQQANSAITSVSNVQYNNETSTTKAVEKVQNAVVSVINYQKSA
NNSLGAIFGNIESSDELAVAGEGSGVIYKKDGQYAYIVTNTHVINNAEKIDILLASGEKISGELVGSDTYSDIAVIKISA
DKVTAVAEFADSDTIKVGETAIAIGSPLGSVYANTVTQGIISSLSRTVTSQSKDGQTISTNAIQTDTAINPGNSGGPLIN
TQGQVIGITSSKITSSSANSSGVAVEGLGFAIPANDAVAIINQLEKTGQVSRPALGVHMVNLTTLSTSQLEKAGLSNTEL
TSGVVIVSTQSGLPADGKLETFDVITEIDGEAIQNKSDLQSALYKHQIGDTITVTYYRNNQKQTVDIKLTHSTEELSE
Nucleotide
Download Length: 1197 bp
>NTDB_id=298505 DK877_RS11020 WP_009911075.1 2220320..2221516(+) (htrA) [Streptococcus suis strain ISU2414]
ATGGAAAGGATTCCTTATATGAAAAAATATTTGAAATTTGCGATTTTATTTGTAATTGGATTTTTTGGGGGTCTTATCGG
GGCCTTATCAGCCTCTTTCTTCCAGCCACGGGTTCAACAAGCAAATTCTGCCATCACTAGTGTCAGCAATGTTCAATATA
ATAATGAAACTTCTACTACAAAGGCTGTAGAGAAAGTACAAAATGCTGTTGTGTCTGTTATTAATTACCAAAAGTCAGCC
AACAATAGTCTTGGTGCTATCTTTGGAAATATTGAATCATCTGACGAACTAGCCGTTGCTGGGGAGGGATCTGGTGTTAT
CTACAAAAAAGATGGTCAATATGCCTATATTGTGACAAATACGCATGTTATTAATAACGCAGAAAAGATTGATATCCTTT
TAGCATCTGGAGAAAAAATTAGCGGTGAACTTGTTGGTTCTGATACATATTCTGATATAGCTGTTATAAAAATATCAGCA
GATAAAGTCACTGCTGTTGCTGAATTTGCTGATTCCGATACAATTAAAGTTGGAGAAACTGCTATCGCAATTGGTAGTCC
TCTAGGTAGCGTCTACGCCAATACAGTTACCCAGGGTATTATTTCTAGCTTAAGTCGGACAGTTACTTCACAATCAAAAG
ATGGACAAACAATCTCAACTAACGCTATTCAAACTGATACAGCTATCAACCCTGGAAACTCTGGCGGACCGTTAATCAAT
ACCCAAGGACAAGTGATAGGCATTACCTCTAGCAAAATTACCTCAAGTTCTGCAAATAGCTCAGGCGTGGCTGTAGAAGG
GTTGGGATTTGCTATTCCTGCAAATGATGCCGTAGCTATTATCAATCAGCTTGAAAAAACTGGACAAGTTAGCCGACCTG
CTCTTGGAGTTCATATGGTTAACTTGACGACCTTGTCAACTAGTCAATTAGAAAAAGCTGGATTATCAAATACGGAATTA
ACATCCGGTGTAGTAATTGTCTCTACACAAAGTGGGCTACCTGCAGATGGAAAATTAGAAACTTTTGATGTTATTACTGA
GATTGACGGAGAAGCTATTCAAAATAAGAGTGACCTCCAGAGCGCTCTCTACAAACATCAAATTGGAGATACAATCACTG
TAACTTATTACCGCAATAATCAGAAACAAACTGTTGACATTAAGTTGACACATTCTACAGAAGAACTTAGCGAATAA
ATGGAAAGGATTCCTTATATGAAAAAATATTTGAAATTTGCGATTTTATTTGTAATTGGATTTTTTGGGGGTCTTATCGG
GGCCTTATCAGCCTCTTTCTTCCAGCCACGGGTTCAACAAGCAAATTCTGCCATCACTAGTGTCAGCAATGTTCAATATA
ATAATGAAACTTCTACTACAAAGGCTGTAGAGAAAGTACAAAATGCTGTTGTGTCTGTTATTAATTACCAAAAGTCAGCC
AACAATAGTCTTGGTGCTATCTTTGGAAATATTGAATCATCTGACGAACTAGCCGTTGCTGGGGAGGGATCTGGTGTTAT
CTACAAAAAAGATGGTCAATATGCCTATATTGTGACAAATACGCATGTTATTAATAACGCAGAAAAGATTGATATCCTTT
TAGCATCTGGAGAAAAAATTAGCGGTGAACTTGTTGGTTCTGATACATATTCTGATATAGCTGTTATAAAAATATCAGCA
GATAAAGTCACTGCTGTTGCTGAATTTGCTGATTCCGATACAATTAAAGTTGGAGAAACTGCTATCGCAATTGGTAGTCC
TCTAGGTAGCGTCTACGCCAATACAGTTACCCAGGGTATTATTTCTAGCTTAAGTCGGACAGTTACTTCACAATCAAAAG
ATGGACAAACAATCTCAACTAACGCTATTCAAACTGATACAGCTATCAACCCTGGAAACTCTGGCGGACCGTTAATCAAT
ACCCAAGGACAAGTGATAGGCATTACCTCTAGCAAAATTACCTCAAGTTCTGCAAATAGCTCAGGCGTGGCTGTAGAAGG
GTTGGGATTTGCTATTCCTGCAAATGATGCCGTAGCTATTATCAATCAGCTTGAAAAAACTGGACAAGTTAGCCGACCTG
CTCTTGGAGTTCATATGGTTAACTTGACGACCTTGTCAACTAGTCAATTAGAAAAAGCTGGATTATCAAATACGGAATTA
ACATCCGGTGTAGTAATTGTCTCTACACAAAGTGGGCTACCTGCAGATGGAAAATTAGAAACTTTTGATGTTATTACTGA
GATTGACGGAGAAGCTATTCAAAATAAGAGTGACCTCCAGAGCGCTCTCTACAAACATCAAATTGGAGATACAATCACTG
TAACTTATTACCGCAATAATCAGAAACAAACTGTTGACATTAAGTTGACACATTCTACAGAAGAACTTAGCGAATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| htrA | Streptococcus mutans UA159 |
59.446 |
99.749 |
0.593 |
| htrA | Streptococcus gordonii str. Challis substr. CH1 |
59.494 |
99.246 |
0.59 |
| htrA | Streptococcus pneumoniae D39 |
57.252 |
98.744 |
0.565 |
| htrA | Streptococcus pneumoniae TIGR4 |
57.252 |
98.744 |
0.565 |
| htrA | Streptococcus mitis NCTC 12261 |
57.252 |
98.744 |
0.565 |
| htrA | Streptococcus pneumoniae R6 |
57.252 |
98.744 |
0.565 |
| htrA | Streptococcus pneumoniae Rx1 |
57.252 |
98.744 |
0.565 |