Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   EQH45_RS00435 Genome accession   NZ_CP035235
Coordinates   75159..77312 (+) Length   717 a.a.
NCBI ID   WP_000668302.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1902276     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 70159..82312
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH45_RS00405 (EQH45_00420) - 70511..71680 (+) 1170 WP_000366341.1 pyridoxal phosphate-dependent aminotransferase -
  EQH45_RS00410 (EQH45_00425) recO 71677..72447 (+) 771 WP_000616164.1 DNA repair protein RecO Machinery gene
  EQH45_RS00415 (EQH45_00430) plsX 72444..73436 (+) 993 WP_000717460.1 phosphate acyltransferase PlsX -
  EQH45_RS00420 (EQH45_00435) - 73442..73675 (+) 234 WP_000136449.1 acyl carrier protein -
  EQH45_RS00425 (EQH45_00440) - 73712..74011 (+) 300 Protein_80 transposase family protein -
  EQH45_RS00430 (EQH45_00445) blpU 74214..74444 (+) 231 WP_001093071.1 bacteriocin-like peptide BlpU -
  EQH45_RS11040 - 74447..74572 (+) 126 WP_000346297.1 PncF family bacteriocin immunity protein -
  EQH45_RS00435 (EQH45_00450) comA 75159..77312 (+) 2154 WP_000668302.1 peptide cleavage/export ABC transporter ComA Regulator
  EQH45_RS00440 (EQH45_00455) comB 77325..78674 (+) 1350 WP_000801623.1 competence pheromone export protein ComB Regulator
  EQH45_RS00445 (EQH45_00460) purC 78844..79551 (+) 708 WP_000043312.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  EQH45_RS11120 (EQH45_00465) - 79553..79696 (+) 144 WP_050167432.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80456.50 Da        Isoelectric Point: 6.2590

>NTDB_id=294882 EQH45_RS00435 WP_000668302.1 75159..77312(+) (comA) [Streptococcus pneumoniae strain TVO_1902276]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPYKEQKNGLLSFIPI
LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLFSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNSLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGSVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLIALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=294882 EQH45_RS00435 WP_000668302.1 75159..77312(+) (comA) [Streptococcus pneumoniae strain TVO_1902276]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTTATAAGGAACAAAAAAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAACAGTATCATCGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTCTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTTTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATTCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTAGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTATCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATAGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTAGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterProScan.

ABC transporter (ABC_tran)

(500-650)

ABC transporter transmembrane region (ABC_membrane)

(170-438)

Peptidase C39 family (Peptidase_C39)

(7-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae Rx1

99.442

100

0.994
  comA Streptococcus pneumoniae D39

99.442

100

0.994
  comA Streptococcus pneumoniae R6

99.442

100

0.994
  comA Streptococcus pneumoniae TIGR4

99.303

100

0.993
  comA Streptococcus mitis SK321

97.908

100

0.979
  comA Streptococcus mitis NCTC 12261

97.908

100

0.979
  comA Streptococcus gordonii str. Challis substr. CH1

80.195

100

0.802
  comA/nlmT Streptococcus mutans UA159

64.296

100

0.643

Multiple sequence alignment