Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   DKM32_RS02115 Genome accession   NZ_CP029536
Coordinates   433762..435954 (-) Length   730 a.a.
NCBI ID   WP_016379452.1    Uniprot ID   -
Organism   Lacticaseibacillus paracasei strain LC355     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 425860..444291 433762..435954 within 0


Gene organization within MGE regions


Location: 425860..444291
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DKM32_RS02060 - 425860..426489 (+) 630 WP_003588778.1 helix-turn-helix domain-containing protein -
  DKM32_RS02065 - 426625..426954 (+) 330 WP_003567322.1 PadR family transcriptional regulator -
  DKM32_RS02070 - 426951..427739 (+) 789 WP_003588780.1 hypothetical protein -
  DKM32_RS02075 - 427792..428580 (+) 789 WP_003580842.1 hypothetical protein -
  DKM32_RS02080 - 428625..428903 (-) 279 WP_003567328.1 bacteriocin immunity protein -
  DKM32_RS02085 - 428927..429211 (-) 285 WP_003580845.1 bacteriocin immunity protein -
  DKM32_RS02090 - 429405..429701 (-) 297 WP_003588783.1 bacteriocin immunity protein -
  DKM32_RS02095 - 429803..431158 (-) 1356 WP_003567335.1 threonine/serine exporter ThrE family protein -
  DKM32_RS02100 - 431464..431775 (-) 312 WP_003580849.1 hypothetical protein -
  DKM32_RS02105 - 431848..432198 (-) 351 WP_003567340.1 hypothetical protein -
  DKM32_RS02110 - 432372..433751 (-) 1380 WP_003588791.1 bacteriocin secretion accessory protein -
  DKM32_RS02115 comA 433762..435954 (-) 2193 WP_016379452.1 peptide cleavage/export ABC transporter Regulator
  DKM32_RS02120 - 436419..436556 (-) 138 WP_003576291.1 bacteriocin-like peptide, LSEI_2386 family -
  DKM32_RS02125 - 436746..438044 (+) 1299 WP_045603255.1 GHKL domain-containing protein -
  DKM32_RS02130 - 438049..438543 (+) 495 Protein_394 response regulator -
  DKM32_RS02135 - 438565..439485 (-) 921 WP_003574021.1 IS30 family transposase -
  DKM32_RS02140 - 439596..439910 (+) 315 Protein_396 LytTR family DNA-binding domain-containing protein -
  DKM32_RS02145 - 440272..440469 (-) 198 WP_003661762.1 hypothetical protein -
  DKM32_RS02150 - 441016..441255 (+) 240 WP_003588828.1 hypothetical protein -
  DKM32_RS16590 - 441489..441740 (+) 252 WP_003586983.1 IS3 family transposase -
  DKM32_RS02160 - 441794..442636 (+) 843 WP_029327644.1 IS3 family transposase -
  DKM32_RS02165 - 442869..443036 (-) 168 WP_404882601.1 bacteriocin leader domain-containing protein -
  DKM32_RS02170 - 443144..443986 (-) 843 WP_029327644.1 IS3 family transposase -
  DKM32_RS16595 - 444040..444291 (-) 252 WP_003586983.1 IS3 family transposase -

Sequence

Protein


Download         Length: 730 a.a.        Molecular weight: 81334.56 Da        Isoelectric Point: 7.0227

>NTDB_id=293315 DKM32_RS02115 WP_016379452.1 433762..435954(-) (comA) [Lacticaseibacillus paracasei strain LC355]
MIKYNLKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDSSVAMTWLPKERFAKEWSGVAIFIAPEPQYQPRKED
KGSLFAFVPMLARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGMIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
TDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHTELLAK
QGYYARLVSE

Nucleotide


Download         Length: 2193 bp        

>NTDB_id=293315 DKM32_RS02115 WP_016379452.1 433762..435954(-) (comA) [Lacticaseibacillus paracasei strain LC355]
ATGATCAAATACAACCTAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGCTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAGTTGGCGAAGA
CGGATCAGGAAGGAACAACAGCGTTAGGGATTGTCCGAGCTGCTCAGGCGCTTCATTTTGAAACCAAGGCTGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTGGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATTCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCGCCAGAACCGCAATATCAACCACGCAAAGAGGAC
AAAGGCAGTCTCTTTGCGTTTGTGCCGATGCTAGCGCGACAAAAAGGAATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATCACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATGATTGCCAGTGGTCTCATCCTCGCTTATGTGCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAACGTTTGTCGATTGATGTCATTTTGGGTTACGTCAGACACCTTTATGAATTACCTATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAAATTGTGTCGCGGTTTTCCGATGCTAATAAAATTATTGATGCGCTGGCGAACACGATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATTTTGAGTTCATCTATTATCGAGGATTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACGTATTTGAAAAAGTCGTTCAATTATACAAAAGCTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACCAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGGCTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCCATCAATGTTACCGATGTGTCCTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAACAAATCAACCTTGAAATCCCGGAAAATGCCAAATACACCATTGTCGGCATGAGTGGATCAGGGAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACTGGCAAAGGGAAAATCACATTTAATGGGGTTCCAATC
ACTGATGTTGATCTAACAACGTTACGACAATATATCGAGTATGTACCACAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCGGAAATTGCCG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCCATTGCCCGCGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCAATGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTCACTATTG
CTGCTAAAACGGAACAGATTGTGGTCATGGACCATGGTGCGATTGTTGAACAAGGAAATCATACTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(510-662)

Peptidase C39 family (Peptidase_C39)

(16-152)

ABC transporter transmembrane region (ABC_membrane)

(180-448)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

58.635

98.356

0.577
  comA Streptococcus pneumoniae Rx1

58.078

98.356

0.571
  comA Streptococcus pneumoniae D39

58.078

98.356

0.571
  comA Streptococcus pneumoniae R6

58.078

98.356

0.571
  comA Streptococcus mitis SK321

57.939

98.356

0.57
  comA Streptococcus pneumoniae TIGR4

57.66

98.356

0.567
  comA Streptococcus gordonii str. Challis substr. CH1

56.964

98.356

0.56
  comA/nlmT Streptococcus mutans UA159

54.848

98.904

0.542

Multiple sequence alignment