Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DK182_RS08895 Genome accession   NZ_CP029491
Coordinates   1816748..1818622 (-) Length   624 a.a.
NCBI ID   WP_019775539.1    Uniprot ID   -
Organism   Streptococcus sobrinus strain 10919     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1811748..1823622
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK182_RS08870 (DK181_08870) - 1812053..1812403 (-) 351 WP_019771104.1 S1 RNA-binding domain-containing protein -
  DK182_RS08875 (DK181_08875) - 1812403..1813800 (-) 1398 WP_019771105.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DK182_RS08880 (DK181_08880) - 1813904..1814554 (-) 651 WP_019770084.1 response regulator -
  DK182_RS08885 (DK181_08885) - 1814532..1815575 (-) 1044 WP_002960295.1 sensor histidine kinase -
  DK182_RS08890 (DK181_08890) liaF 1815572..1816270 (-) 699 WP_019770059.1 cell wall-active antibiotics response protein LiaF -
  DK182_RS08895 (DK181_08895) pknB 1816748..1818622 (-) 1875 WP_019775539.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DK182_RS08900 (DK181_08900) - 1818619..1819362 (-) 744 WP_002960300.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DK182_RS08905 (DK181_08905) rsmB 1819512..1820837 (-) 1326 WP_019791793.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DK182_RS08910 (DK181_08910) fmt 1820821..1821756 (-) 936 WP_019769792.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 624 a.a.        Molecular weight: 67382.66 Da        Isoelectric Point: 6.5267

>NTDB_id=293230 DK182_RS08895 WP_019775539.1 1816748..1818622(-) (pknB) [Streptococcus sobrinus strain 10919]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILEGEEVAIKVLRTNYQTDQVAVTRFQREARAMAELSHPNIVSIRDIG
EEDGQQFLVMEYVDGLDLKHYIQEKAPLSNSEVVRIMEEVLSAMTLAHEKGIIHRDLKPQNILLTKEGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIREINSEVP
QALENVVIKATAKRLADRYQSTYEMSRDLMSSLSYNRSREAKLVFSDVADTKTLPKIDTNTANASTEQLLKATDKNAKAK
EPANPAPKKKVKPKRKHKASVFSKVAIGVVLVLIALVAFFMLRNPSSVSVPDVSGQDLSTARSTIKKSGFKVGQVIKVES
DSVAKGKVVRTDPAAGSSKKEGTSVDIYVSGSGSKFKMKDYTGKDIDTVKKELESDYGVKESQIEVTEVSTSDYDEGTII
SQSPSKGDKFDTSGDDTIKFTVAVSGSTTMPNLTGMTYSQAISTLTAIGVKSSRIKIYSSSTGSETSPSSSSIISGQNPY
YGASLDLSSSDEIVLYVQDASSRSSSSSSSTSSNSSSSSSSSSSENPQQDDSDNSNSSESNGNQ

Nucleotide


Download         Length: 1875 bp        

>NTDB_id=293230 DK182_RS08895 WP_019775539.1 1816748..1818622(-) (pknB) [Streptococcus sobrinus strain 10919]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGCTATCGCATCCTCAAGTCCATCGGTCGAGGTGGGATGGCCGACGTTTA
CTTGGCTAACGATCTGATTTTAGAAGGAGAAGAAGTTGCCATCAAGGTACTTCGAACTAACTATCAGACCGACCAAGTCG
CTGTGACTCGTTTTCAGCGAGAAGCGCGGGCCATGGCTGAACTCAGCCACCCTAATATCGTTTCTATTAGAGATATTGGC
GAAGAAGATGGACAGCAATTCCTAGTAATGGAATACGTCGATGGTTTAGACCTCAAGCATTATATTCAAGAAAAGGCGCC
ATTATCCAATTCTGAAGTTGTCAGGATTATGGAAGAAGTCCTTTCAGCTATGACCCTGGCCCATGAGAAAGGAATCATTC
ACCGGGACCTCAAGCCTCAGAATATTCTTTTAACCAAGGAGGGCACAGTCAAAGTTACTGACTTCGGAATTGCCGTGGCC
TTTGCGGAAACCAGCCTGACACAGACCAATTCTATGCTGGGTAGTGTCCACTATCTTTCGCCAGAACAGGCGCGTGGTTC
CAAAGCAACGGTCCAGTCCGATATTTATGCCATGGGAATTATGCTCTTTGAAATGCTGACAGGTCACATTCCTTATGATG
GCGACAGTGCCGTGACCATTGCCCTCCAGCATTTTCAAAAACCCCTGCCTTCCATTAGAGAAATCAATTCAGAGGTTCCC
CAAGCCTTGGAAAATGTTGTCATTAAGGCAACAGCAAAAAGGTTGGCGGATCGCTATCAATCGACCTATGAAATGAGTCG
AGACCTCATGTCTAGTCTCAGCTATAACCGTAGCCGAGAAGCTAAATTGGTCTTTTCAGATGTGGCAGATACTAAAACCC
TGCCTAAGATTGATACTAATACAGCTAACGCTTCCACAGAGCAGCTGCTGAAGGCCACCGATAAGAATGCTAAGGCTAAG
GAGCCTGCAAATCCAGCACCTAAGAAAAAGGTTAAACCTAAGCGTAAGCATAAGGCTAGTGTCTTTAGCAAGGTTGCAAT
CGGTGTAGTCCTAGTGTTGATTGCACTGGTTGCCTTCTTCATGTTGCGAAATCCATCTTCGGTTAGTGTCCCAGATGTTT
CTGGACAGGATTTATCAACAGCTCGATCAACTATTAAGAAATCCGGTTTTAAAGTCGGCCAAGTCATTAAGGTAGAGAGT
GATTCTGTTGCTAAGGGTAAGGTTGTTCGGACCGACCCTGCTGCAGGAAGTTCGAAAAAAGAGGGAACCTCGGTCGATAT
CTATGTTTCTGGAAGTGGCAGTAAATTTAAGATGAAGGACTACACCGGCAAAGATATTGACACTGTCAAGAAGGAATTAG
AGTCTGATTATGGTGTCAAAGAGTCCCAGATAGAGGTGACGGAAGTTTCCACATCTGATTACGATGAGGGCACCATCATC
AGTCAAAGCCCTTCTAAGGGAGATAAATTTGATACCTCAGGTGATGATACCATTAAATTTACGGTTGCTGTTTCAGGGTC
AACAACCATGCCTAATTTAACAGGGATGACTTATTCTCAGGCAATTTCTACCCTGACAGCCATTGGTGTTAAATCGTCAC
GGATTAAGATTTATTCATCATCAACAGGATCTGAAACCTCCCCTTCATCATCTAGCATCATTTCTGGACAAAATCCATAC
TATGGAGCTAGCCTAGATTTATCATCTAGCGACGAGATTGTTCTCTATGTACAGGATGCTTCATCGAGGTCATCCAGCTC
ATCAAGTTCAACGTCATCGAATTCGTCAAGTTCATCAAGTTCATCAAGTTCAGAAAATCCCCAACAAGATGATAGTGACA
ACTCAAATTCGTCTGAAAGCAACGGGAATCAATGA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(368-431)

PASTA domain (PASTA)

(437-503)

PASTA domain (PASTA)

(509-577)

Protein kinase domain (Pkinase)

(12-254)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

66.954

93.109

0.623
  stkP/pknB Streptococcus salivarius strain HSISS4

62.669

94.872

0.595
  stkP Streptococcus pneumoniae TIGR4

54.124

93.269

0.505
  stkP Streptococcus pneumoniae D39

54.124

93.269

0.505
  stkP Streptococcus pneumoniae R6

54.124

93.269

0.505
  stkP Streptococcus pneumoniae Rx1

53.952

93.269

0.503

Multiple sequence alignment