Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DK181_RS09150 Genome accession   NZ_CP029490
Coordinates   1869901..1871766 (-) Length   621 a.a.
NCBI ID   WP_002960298.1    Uniprot ID   -
Organism   Streptococcus sobrinus strain SL1     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1864901..1876766
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK181_RS09125 (DK182_09125) - 1865206..1865556 (-) 351 WP_002960289.1 S1 RNA-binding domain-containing protein -
  DK181_RS09130 (DK182_09130) - 1865556..1866953 (-) 1398 WP_002960291.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DK181_RS09135 (DK182_09135) - 1867057..1867707 (-) 651 WP_019770084.1 response regulator -
  DK181_RS09140 (DK182_09140) - 1867685..1868728 (-) 1044 WP_002960295.1 sensor histidine kinase -
  DK181_RS09145 (DK182_09145) liaF 1868725..1869423 (-) 699 WP_002960296.1 cell wall-active antibiotics response protein LiaF -
  DK181_RS09150 (DK182_09150) pknB 1869901..1871766 (-) 1866 WP_002960298.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DK181_RS09155 (DK182_09155) - 1871763..1872506 (-) 744 WP_002960300.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DK181_RS09160 (DK182_09160) rsmB 1872656..1873981 (-) 1326 WP_019785496.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DK181_RS09165 (DK182_09165) fmt 1873965..1874900 (-) 936 WP_002960303.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 621 a.a.        Molecular weight: 67016.20 Da        Isoelectric Point: 6.3414

>NTDB_id=293177 DK181_RS09150 WP_002960298.1 1869901..1871766(-) (pknB) [Streptococcus sobrinus strain SL1]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILEGEEVAIKVLRTNYQTDQVAVTRFQREARAMAELSHPNIVSIRDIG
EEDGQQFLVMEYVDGLDLKHYIQEKAPLSNSEVVRIMEEVLSAMTLAHEKGIIHRDLKPQNILLTKEGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIREINSEVP
QALENVAIKATAKRLTDRYQSTYEMSRDLMSSLSYNRSREAKLVFSDVADTKTLPKIDTNTANASTEQLLKATDKNAKAK
ESANPAPKKKVKPKRKHKASVFSKVAIGVALVLIALVAFFMLRNPSSVSVPDVSGQDLSTARSTIKKSGFKVGQVIKVES
DSVAKGKVVRTDPAAGSSKKEGTSVDIYVSGSGSKFKMKDYTGKDIDTVKKELESDYGVKESQIEVTEVSTSDYDEGTII
SQSPSKGDKFDTSGDDTIKFTVAVSGSTTMPNLTGMTYSQAISTLTAIGVKSSRIKIYSSSTGSETSPSSSSIISGQNPY
YGASLDLSSSDEIVLYVQDASSSSSSSSSSTSSNSSSSSSSENPQQDDSDNSNSSESNGNQ

Nucleotide


Download         Length: 1866 bp        

>NTDB_id=293177 DK181_RS09150 WP_002960298.1 1869901..1871766(-) (pknB) [Streptococcus sobrinus strain SL1]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGCTATCGCATCCTCAAGTCCATCGGTCGAGGTGGGATGGCCGACGTTTA
CTTGGCTAACGATCTGATTTTAGAAGGAGAAGAAGTTGCCATCAAGGTACTTCGAACTAACTATCAGACCGACCAAGTCG
CTGTGACTCGTTTTCAGCGAGAAGCGCGGGCCATGGCTGAACTCAGCCACCCTAATATCGTTTCTATTAGAGATATTGGC
GAAGAAGATGGACAGCAATTCCTAGTAATGGAATACGTCGATGGTTTAGACCTCAAGCATTATATTCAAGAAAAGGCGCC
ATTATCCAATTCTGAAGTTGTCAGGATTATGGAAGAAGTCCTTTCAGCTATGACCCTGGCCCATGAGAAAGGAATCATTC
ACCGGGACCTCAAGCCTCAGAATATTCTTTTAACCAAGGAGGGAACAGTCAAAGTTACTGACTTCGGAATTGCCGTGGCC
TTTGCGGAAACCAGCCTGACACAGACCAATTCTATGCTGGGTAGTGTCCACTATCTTTCGCCAGAACAGGCGCGTGGTTC
CAAAGCAACGGTCCAGTCCGATATTTATGCCATGGGGATTATGCTCTTTGAAATGCTGACAGGTCACATTCCTTATGATG
GCGACAGTGCCGTGACCATTGCCCTCCAGCATTTTCAAAAACCCCTGCCTTCCATTAGAGAAATCAATTCAGAGGTTCCC
CAAGCCTTGGAAAATGTTGCCATTAAGGCAACAGCAAAAAGGTTGACGGATCGCTATCAATCAACCTATGAAATGAGTCG
AGACCTCATGTCTAGTCTCAGCTATAACCGTAGCCGAGAAGCTAAATTGGTCTTTTCAGATGTGGCAGATACTAAAACCC
TGCCTAAGATTGATACTAATACAGCTAACGCTTCCACAGAGCAGCTGCTGAAGGCTACCGATAAGAATGCTAAGGCTAAG
GAGTCTGCAAATCCAGCACCTAAGAAAAAGGTTAAACCTAAGCGTAAGCATAAGGCTAGTGTCTTTAGCAAGGTTGCAAT
CGGTGTAGCCCTAGTGTTGATTGCACTGGTTGCCTTCTTCATGTTGCGAAATCCATCTTCGGTTAGTGTCCCAGATGTTT
CTGGACAGGATTTATCAACAGCTCGATCAACTATTAAGAAATCCGGTTTTAAAGTCGGCCAAGTCATTAAGGTAGAGAGT
GATTCTGTTGCTAAGGGTAAGGTTGTTCGGACCGACCCTGCTGCAGGAAGTTCGAAAAAAGAGGGAACCTCGGTCGATAT
CTATGTTTCTGGAAGTGGCAGTAAATTTAAGATGAAGGACTACACCGGCAAAGATATTGACACTGTCAAGAAGGAATTAG
AGTCTGATTATGGTGTCAAAGAGTCCCAGATAGAGGTGACGGAAGTTTCCACATCTGATTACGATGAGGGCACCATCATC
AGTCAAAGCCCTTCTAAGGGAGATAAATTTGATACCTCAGGTGATGATACCATTAAATTTACGGTTGCTGTTTCAGGGTC
AACAACCATGCCTAATTTAACAGGGATGACTTATTCTCAAGCAATTTCTACCCTGACAGCCATTGGTGTTAAATCGTCAC
GGATTAAGATTTATTCATCATCAACAGGATCTGAAACCTCCCCTTCATCATCTAGCATCATTTCTGGACAAAATCCATAC
TATGGAGCTAGCCTAGATTTATCATCTAGCGACGAGATTGTTCTCTATGTACAGGATGCTTCATCGAGTTCATCCAGCTC
ATCAAGTTCAACGTCATCGAATTCGTCAAGTTCATCAAGTTCAGAAAATCCCCAACAAGATGATAGTGACAACTCAAATT
CGTCTGAAAGCAACGGGAATCAATGA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-256)

PASTA domain (PASTA)

(437-503)

PASTA domain (PASTA)

(368-431)

PASTA domain (PASTA)

(509-577)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

66.954

93.559

0.626
  stkP/pknB Streptococcus salivarius strain HSISS4

62.162

95.33

0.593
  stkP Streptococcus pneumoniae D39

54.153

96.94

0.525
  stkP Streptococcus pneumoniae R6

54.153

96.94

0.525
  stkP Streptococcus pneumoniae TIGR4

54.153

96.94

0.525
  stkP Streptococcus pneumoniae Rx1

53.987

96.94

0.523

Multiple sequence alignment