Detailed information NTG0292299

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DF184_RS10815
• Genome accession: NZ_CP029398
• Coordinates: 2194508..2195704 (+)
• Length: 398 a.a.
• NCBI ID: WP_024384306.1
• Uniprot ID: A0A2S2F7U7
• Organism: Streptococcus suis strain HN105
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2189508..2200704

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DF184_RS10795 (DF184_10795)	-	2191600..2192763 (+)	1164	WP_109371047.1	IS30 family transposase	-
DF184_RS10805 (DF184_10805)	-	2193147..2193830 (-)	684	WP_012775416.1	YoaK family protein	-
DF184_RS10810 (DF184_10810)	rlmH	2193855..2194334 (-)	480	WP_004194528.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DF184_RS10815 (DF184_10815)	htrA	2194508..2195704 (+)	1197	WP_024384306.1	trypsin-like peptidase domain-containing protein	Regulator
DF184_RS10820 (DF184_10820)	spo0J	2195765..2196529 (+)	765	WP_029186209.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 398 a.a.
• Molecular weight: 41866.89 Da
• Isoelectric Point: 4.4971

>NTDB_id=292299 DF184_RS10815 WP_024384306.1 2194508..2195704(+) (htrA) [Streptococcus suis strain HN105]
MERIPYMKKYLKFAILFVIGFFGGLIGALSASFFQPQVQQANSAITSVSNVQYNNETSTTKAVEKVQNAVVSVINYQKSA
NNSLGAIFGNIESSDELAVAGEGSGVIYKKDGQYAYIVTNTHVINNAEKIDILLASGEKISGELVGSDTYSDIAVIKISA
DKVTTVAEFADSDTIKVGETAIAIGSPLGSVYANTVTQGIISSLSRTVTSQSEDGQTISTNAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKITSSSVSSSGVAVEGMGFAIPANDAVAIINQLEKDGKVSRPALGVHMVNLTTLSTSQLEKAGLSNTEL
TSGVVIVSTQSGLPADGKLETFDVITEIDGEAIQNKSDLQSALYKHQIGDTITVTYYRNNQKQTVDIKLTHSTEELSE

Nucleotide

• Length: 1197 bp

>NTDB_id=292299 DF184_RS10815 WP_024384306.1 2194508..2195704(+) (htrA) [Streptococcus suis strain HN105]
ATGGAAAGGATTCCTTATATGAAAAAATATTTGAAATTTGCGATTCTATTTGTAATTGGATTTTTTGGGGGTCTTATCGG
GGCCTTATCAGCCTCTTTCTTCCAACCACAGGTTCAACAAGCAAATTCTGCTATCACTAGTGTCAGCAATGTTCAATATA
ATAATGAAACTTCCACCACAAAAGCTGTAGAGAAAGTACAAAATGCTGTTGTGTCTGTTATTAATTACCAAAAGTCAGCC
AACAATAGTCTTGGTGCTATCTTTGGAAATATTGAATCATCTGACGAACTAGCTGTTGCTGGAGAGGGGTCTGGGGTTAT
CTATAAAAAAGATGGTCAATATGCCTATATTGTGACAAATACGCATGTTATTAATAACGCAGAAAAGATTGATATTCTTT
TAGCATCTGGAGAAAAAATCAGCGGTGAACTCGTTGGTTCCGATACCTATTCTGATATAGCTGTTATAAAAATATCAGCA
GATAAAGTCACTACTGTTGCTGAATTTGCTGATTCCGATACAATTAAAGTTGGAGAAACTGCTATCGCAATTGGTAGTCC
TCTAGGTAGTGTCTACGCCAATACAGTTACTCAAGGTATTATTTCCAGCCTAAGTCGGACAGTTACTTCACAATCAGAAG
ACGGACAAACAATCTCAACCAATGCTATTCAAACCGATACAGCTATCAACCCAGGAAACTCTGGTGGACCATTGATTAAT
ATCCAAGGACAAGTTATTGGTATCACCTCTAGCAAAATCACCTCAAGTTCTGTAAGTAGCTCTGGTGTAGCTGTGGAAGG
GATGGGATTTGCTATTCCTGCAAATGATGCCGTAGCTATTATCAATCAACTTGAAAAAGATGGAAAAGTTAGCCGACCTG
CTCTTGGAGTTCATATGGTTAACTTGACGACCTTGTCAACTAGTCAATTGGAAAAAGCTGGATTATCAAATACGGAATTA
ACATCCGGTGTAGTAATTGTCTCTACACAAAGTGGACTACCTGCAGATGGAAAATTAGAAACTTTTGATGTTATTACTGA
GATTGACGGAGAAGCTATTCAAAATAAGAGTGACCTCCAGAGCGCTCTCTACAAACATCAAATTGGAGATACAATCACTG
TAACTTATTACCGCAATAATCAGAAACAAACTGTTGACATTAAGTTGACACATTCTACAGAAGAACTTAGCGAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (293-389)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

3D structure

• AlphaFold DB: A0A2S2F7U7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	60.705	99.749	0.606
htrA	Streptococcus gordonii str. Challis substr. CH1	60.506	99.246	0.6
htrA	Streptococcus pneumoniae D39	57.761	98.744	0.57
htrA	Streptococcus pneumoniae TIGR4	57.761	98.744	0.57
htrA	Streptococcus mitis NCTC 12261	57.761	98.744	0.57
htrA	Streptococcus pneumoniae R6	57.761	98.744	0.57
htrA	Streptococcus pneumoniae Rx1	57.761	98.744	0.57