Detailed information NTG0029081

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: SGO_RS07845
• Genome accession: NC_009785
• Coordinates: 1655520..1657760 (-)
• Length: 746 a.a.
• NCBI ID: WP_012130665.1
• Uniprot ID: A8AYL9
• Organism: Streptococcus gordonii str. Challis substr. CH1
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1650520..1662760

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SGO_RS07815 (SGO_1595)	-	1650793..1651290 (-)	498	WP_012130659.1	DUF1648 domain-containing protein	-
SGO_RS07820 (SGO_1596)	-	1651277..1651558 (-)	282	WP_012130660.1	autorepressor SdpR family transcription factor	-
SGO_RS07825 (SGO_1597)	-	1651536..1652324 (-)	789	WP_012130661.1	YhfC family intramembrane metalloprotease	-
SGO_RS07830 (SGO_1598)	-	1652529..1653602 (-)	1074	WP_012130662.1	serine hydrolase	-
SGO_RS07835 (SGO_1599)	-	1653714..1654319 (-)	606	WP_012130663.1	superoxide dismutase	-
SGO_RS07840 (SGO_1600)	holA	1654392..1655429 (-)	1038	WP_012130664.1	DNA polymerase III subunit delta	-
SGO_RS07845 (SGO_1601)	comEC/celB	1655520..1657760 (-)	2241	WP_012130665.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
SGO_RS07850 (SGO_1602)	comEA/celA/cilE	1657744..1658409 (-)	666	WP_012130666.1	helix-hairpin-helix domain-containing protein	Machinery gene
SGO_RS07855 (SGO_1603)	-	1658506..1659033 (-)	528	WP_012130667.1	HXXEE domain-containing protein	-
SGO_RS07860 (SGO_1604)	-	1659072..1659812 (-)	741	WP_041789898.1	lysophospholipid acyltransferase family protein	-
SGO_RS07865 (SGO_1605)	-	1659942..1662311 (+)	2370	WP_012130669.1	cation-translocating P-type ATPase	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 85524.30 Da
• Isoelectric Point: 9.8278

>NTDB_id=29081 SGO_RS07845 WP_012130665.1 1655520..1657760(-) (comEC/celB) [Streptococcus gordonii str. Challis substr. CH1]
MSQWIKKLPLAPIYLCFLLVWLYFAIYSGERLAYLGYSLLIARLIWHYPRKKWLPTLAILIAFSFFFYARRELAERAFQT
QPAPARQVLVLPDTVKVNGDSLSFRGRIDGRLYQLYYKLASPREKKTFQKLTDLVTLEIEAEFNLAEERRNFSGFDYQAY
LKSQGIYRTVKISRIMSSRSSQSTNPFDWLSVWRRKALVFIKSTFPSPMSHYMTGLLFGDLDIDFAEMNGLYSSLGIIHL
FALSGMQVGFFMDVFRKILLRIGLRMETVDWLQFPLSFLYAGLTGFSVSVVRSLVQKLLSQFGVRRLDNFAMTMLVLMLL
MPSFLLTTGGVLSCAYAFIITMLDFEDSSGFRKAVLESLSISLGILPLLIYYFAEFQPWSILLTFLFSIVFDTFMLPLLS
LIFLISPLFAFTQVNVFFQWLEMVIRWVASLSTRPIILGQPNLPLLIILLLVLALLYDFRKQKKIRAGLSLLAILLFFLS
KHPLQNEITVVDIGQGDSIFLRDVRGRTIVIDTGGRVEIGKKEAWQERVRKSNAETTLIPYLKSRGVDHLDQLVLTHTDT
DHMGDMLELAKHFSIREIYVSKGSMTQVDFVDKLKKMKAKVHVVEVGDRLPIFDSALEVLYPLGQGDGGNDDSIVLYGEF
FRTKFLFTGDLEAPGEGQMVTAYPDLRVDVLKAGHHGSKGSSSPEFLEHIKPKLALISAGKNNRYQHPHKETLDRFEKIQ
TKIFRTDEQGAIRFKGWNSWQIETVR

Nucleotide

• Length: 2241 bp

>NTDB_id=29081 SGO_RS07845 WP_012130665.1 1655520..1657760(-) (comEC/celB) [Streptococcus gordonii str. Challis substr. CH1]
ATGTCACAGTGGATTAAAAAACTTCCCCTTGCTCCAATCTACTTGTGCTTTCTTTTGGTTTGGCTATACTTTGCTATTTA
TAGTGGTGAAAGACTCGCTTATCTAGGTTATTCCCTTCTTATAGCTCGCCTAATCTGGCATTATCCAAGAAAGAAATGGT
TGCCAACTTTAGCTATTCTAATTGCTTTCTCTTTCTTTTTTTATGCTAGACGTGAGTTGGCGGAACGAGCTTTTCAGACT
CAACCAGCTCCTGCAAGACAAGTTCTTGTTTTACCAGATACTGTTAAAGTGAATGGAGATTCCCTATCTTTCCGTGGTAG
AATAGACGGAAGACTTTATCAGCTCTACTACAAATTAGCAAGTCCAAGAGAGAAAAAAACTTTTCAAAAACTAACTGACT
TGGTCACTTTAGAGATTGAAGCAGAGTTCAATCTAGCAGAAGAACGGCGCAATTTCTCTGGCTTTGACTATCAGGCTTAT
TTAAAAAGTCAGGGAATCTATCGGACTGTTAAGATCAGTAGGATTATGTCTAGTCGTTCTAGTCAGTCTACTAATCCATT
TGATTGGCTGTCTGTTTGGCGTAGGAAGGCCTTGGTTTTCATTAAGTCTACTTTTCCAAGCCCGATGAGTCACTACATGA
CAGGACTCTTGTTTGGTGATTTAGATATTGATTTTGCAGAGATGAATGGCTTGTACTCAAGTTTAGGAATTATCCATCTT
TTTGCTTTATCAGGAATGCAAGTTGGTTTTTTTATGGATGTCTTTCGGAAAATTCTTCTGCGCATAGGCTTAAGGATGGA
AACGGTAGATTGGTTGCAATTCCCGTTGTCCTTTCTTTATGCAGGTTTGACTGGATTTTCTGTGTCAGTAGTGAGGAGTT
TAGTGCAAAAGTTGTTGTCTCAATTTGGAGTGAGGCGCTTGGATAATTTTGCGATGACCATGCTGGTCCTAATGCTTCTT
ATGCCAAGCTTTCTCCTGACAACAGGCGGAGTCCTATCTTGCGCTTATGCCTTTATCATCACTATGTTGGATTTTGAGGA
TTCTAGTGGTTTTCGTAAAGCCGTGCTAGAGAGTTTAAGTATCTCGTTAGGCATTTTACCACTTCTTATCTATTATTTTG
CAGAATTCCAGCCTTGGTCTATCCTCTTGACCTTCCTTTTTTCAATCGTCTTTGATACATTTATGTTACCTCTCTTGAGT
CTAATTTTTCTCATTTCGCCTTTGTTTGCCTTCACTCAAGTTAATGTCTTCTTCCAATGGCTGGAAATGGTGATTCGTTG
GGTAGCTAGTTTGTCAACAAGGCCGATAATTTTAGGACAGCCAAATCTGCCTTTGCTTATTATTCTCCTGCTGGTCTTAG
CCCTGCTCTATGACTTTAGAAAACAAAAAAAGATTAGAGCTGGCCTGAGTCTCTTAGCAATCTTACTATTTTTCCTAAGT
AAACATCCTTTACAAAATGAAATCACAGTGGTAGATATTGGGCAGGGAGACAGTATATTTCTGAGGGATGTCAGAGGTAG
GACTATCGTAATTGATACAGGGGGTCGGGTGGAGATTGGTAAAAAAGAGGCTTGGCAAGAGCGAGTTAGAAAAAGCAATG
CGGAAACGACCTTGATCCCTTATCTAAAAAGCCGAGGAGTGGACCACTTGGATCAATTAGTCCTGACTCACACAGATACA
GACCATATGGGAGATATGTTGGAGTTGGCCAAGCACTTTTCTATCCGAGAAATTTATGTTTCCAAAGGAAGTATGACTCA
AGTTGATTTTGTAGACAAGTTAAAGAAGATGAAAGCTAAAGTTCATGTGGTCGAGGTGGGAGATCGGCTTCCTATCTTTG
ATTCGGCCCTTGAAGTGCTCTATCCACTAGGTCAAGGAGATGGTGGTAATGATGACTCGATTGTCTTGTATGGTGAATTT
TTCCGGACCAAGTTTCTTTTCACAGGAGATTTAGAAGCTCCAGGTGAAGGTCAGATGGTGACAGCCTATCCAGATTTAAG
AGTAGATGTGCTCAAAGCTGGGCATCATGGTTCTAAAGGATCTTCTAGTCCAGAATTTCTAGAGCATATTAAGCCTAAGT
TGGCCTTGATTTCAGCTGGTAAAAACAACCGTTACCAACATCCCCATAAGGAAACTTTAGATAGATTCGAAAAAATCCAG
ACTAAGATTTTTCGGACAGATGAGCAGGGAGCTATTCGATTTAAAGGCTGGAATTCTTGGCAGATAGAAACGGTTCGCTA
G

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (494-700)

• Competence protein (Competence) (216-460)

3D structure

• AlphaFold DB: A8AYL9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	58.233	100	0.583
comEC/celB	Streptococcus mitis NCTC 12261	57.641	100	0.576
comEC/celB	Streptococcus pneumoniae TIGR4	56.894	100	0.57
comEC/celB	Streptococcus pneumoniae Rx1	56.627	100	0.567
comEC/celB	Streptococcus pneumoniae D39	56.627	100	0.567
comEC/celB	Streptococcus pneumoniae R6	56.627	100	0.567
comEC	Lactococcus lactis subsp. cremoris KW2	50.269	99.732	0.501