Detailed information NTG0284707

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: SK637_RS04300
• Genome accession: NZ_CP028415
• Coordinates: 785252..787492 (+)
• Length: 746 a.a.
• NCBI ID: WP_033688716.1
• Uniprot ID: -
• Organism: Streptococcus mitis strain SK637
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 780252..792492

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SK637_RS04270 (SK637_00834)	frr	780987..781544 (+)	558	WP_001262225.1	ribosome recycling factor	-
SK637_RS04275 (SK637_00835)	cvfB	781604..782458 (+)	855	WP_033688712.1	RNA-binding virulence regulatory protein CvfB	-
SK637_RS04280 (SK637_00836)	-	782466..782681 (+)	216	WP_001232084.1	YozE family protein	-
SK637_RS04285 (SK637_00837)	-	782766..783770 (+)	1005	WP_033688713.1	PhoH family protein	-
SK637_RS04290 (SK637_00838)	-	783982..784551 (+)	570	WP_033688714.1	GNAT family N-acetyltransferase	-
SK637_RS04295 (SK637_00839)	comEA/celA/cilE	784618..785268 (+)	651	WP_033688715.1	helix-hairpin-helix domain-containing protein	Machinery gene
SK637_RS04300 (SK637_00840)	comEC/celB	785252..787492 (+)	2241	WP_033688716.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
SK637_RS10105	-	787634..787858 (+)	225	WP_033688717.1	hypothetical protein	-
SK637_RS04310 (SK637_00841)	-	787891..788478 (+)	588	WP_033688718.1	ATP-binding cassette domain-containing protein	-
SK637_RS04315 (SK637_00842)	-	788482..789666 (+)	1185	WP_033688719.1	membrane protein	-
SK637_RS04320 (SK637_00843)	infC	789974..790504 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
SK637_RS04325 (SK637_00844)	rpmI	790537..790737 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
SK637_RS04330 (SK637_00845)	rplT	790789..791148 (+)	360	WP_000124834.1	50S ribosomal protein L20	-
SK637_RS04335 (SK637_00846)	-	791207..791587 (+)	381	WP_000157153.1	VOC family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84549.09 Da
• Isoelectric Point: 9.5793

>NTDB_id=284707 SK637_RS04300 WP_033688716.1 785252..787492(+) (comEC/celB) [Streptococcus mitis strain SK637]
MLQWIKNFPIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKLAGKVLAICGIFGFWFLFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSDGRIFQVYYKLQSEEEKEAFQALTDLHEIELEGKLSEPEGQRNFGGFDYQAY
LKTQGIYQTLNIKRIQSLQKVGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMDGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFII
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAIARESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLVFLPLLSI
LFALSFLYPVIQLNFIFEWLEGIIRLVSQVASRPLVFGQPNAWFLILLLISLALVYDLRKNIKRIAVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESNKKIEKWQEKVTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKEFVAELLATQTKVRSVTMGENLPIFGSQLEVLSPSKIGDGGHEDTLVLYGKL
FDKNFLFTGNLVEKGEKDLLKQYPNLEVGVLKAGQHGSKKSSSSSFLEQLKPEMTLISVGKNNRTKLPHQETLTRLETIN
SKVYRTDKQGAIRFKGWKNWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=284707 SK637_RS04300 WP_033688716.1 785252..787492(+) (comEC/celB) [Streptococcus mitis strain SK637]
ATGTTACAGTGGATTAAGAATTTCCCCATTCCCCTAATTTACCTGAGTTTTCTGTTACTTTGGCTTTACTACGCCATTTT
TTCAGCATCCTATCTTGCTTTGTTGGGCTTCGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCTTGGAAATTAGCAG
GTAAAGTTCTAGCAATTTGCGGAATTTTTGGATTCTGGTTTCTGTTTCAAAATTGGCAACAGAGCCAAGCGAGTCAAAAT
CTGGCAGATTCTGTTGAAAGGGTACGGATTTTGCCTGACACTATTAAGGTCAATGGTGACAGTCTATCCTTTCGTGGCAA
GTCTGATGGACGCATTTTTCAAGTATATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCCTTAACAGACC
TTCATGAGATAGAACTAGAAGGAAAACTTTCGGAACCAGAGGGGCAGAGGAATTTTGGTGGATTTGACTATCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAGAATCCAGTCACTTCAAAAGGTTGGCAGTTGGGATATAGG
AGAAAATCTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACACATTTTCCAGACCCTATGCGCAATTACATGA
CAGGGCTTTTGCTAGGACATCTGGACACAGATTTTGAGGAGATGAATGAGCTTTATTCTAGTTTAGGAATTATCCACCTT
TTTGCCTTGTCGGGTATGCAGGTAGGCTTTTTCATGGATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACCTATCCCTTTTCCCTTATTTATGCAGGTCTGACAGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTACAAAAGTTACTGGCTCAACATGGTGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTACTCTTTATTATC
ATGCCCAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGTGCTTATGCTTTTATCTTGACCATGACCAGCAAAGAAGG
AGAGGGGCTTAAGGCTATTGCCAGAGAAAGTCTGGTTATTTCCTTGGGAATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCCATCCTCTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGGTCTTCTTACCGCTCTTGTCTATC
TTATTTGCCCTTTCCTTTCTCTATCCAGTTATTCAGCTGAATTTTATTTTTGAATGGTTGGAAGGGATTATTCGCTTGGT
ATCTCAGGTGGCAAGTAGACCTCTAGTCTTTGGTCAACCCAATGCATGGTTTTTAATTTTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAAGGATAGCAGTGTTGAGCTTATTGATTACGGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATTACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTTGGTGGCAAGGCAGAGTCAAATAAGAAAATCGAAAAATGGCAAGAAAAGGTAACTACTAGCAATG
CCCAGCGAACTTTGATCCCCTATCTCAAAAGTCGCGGAGTAGCCAAGATTGACCAGCTAATTTTGACAAATACAGACAAG
GAGCATGTTGGTGATTTGTTGGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCCAAAGGCAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACTGGCGACTCAAACCAAAGTACGCAGTGTGACAATGGGAGAGAATTTGCCCATTTTCG
GAAGTCAGTTAGAAGTCCTATCTCCAAGTAAAATTGGAGATGGAGGTCATGAAGATACCCTGGTTTTGTATGGAAAACTC
TTTGATAAAAACTTTCTTTTCACTGGAAATTTGGTGGAAAAAGGAGAGAAGGACTTGCTGAAGCAATACCCTAACTTAGA
GGTGGGTGTCTTGAAAGCTGGCCAACATGGCTCTAAAAAATCATCAAGTTCATCCTTTTTAGAACAGCTCAAACCAGAGA
TGACTCTTATCTCAGTTGGAAAGAACAATCGAACGAAACTCCCCCATCAGGAAACCTTGACACGACTGGAAACTATCAAT
AGCAAAGTTTACCGAACTGACAAGCAAGGAGCTATACGCTTTAAAGGTTGGAAAAATTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Domain of unknown function (DUF4131) (DUF4131) (31-176)

• Competence protein (Competence) (216-458)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-694)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	93.7	100	0.937
comEC/celB	Streptococcus mitis NCTC 12261	93.289	99.866	0.932
comEC/celB	Streptococcus pneumoniae TIGR4	92.493	100	0.925
comEC/celB	Streptococcus pneumoniae Rx1	91.689	100	0.917
comEC/celB	Streptococcus pneumoniae D39	91.689	100	0.917
comEC/celB	Streptococcus pneumoniae R6	91.689	100	0.917
comEC	Lactococcus lactis subsp. cremoris KW2	44.534	99.33	0.442