Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SK637_RS03605 Genome accession   NZ_CP028415
Coordinates   656696..657433 (+) Length   245 a.a.
NCBI ID   WP_033688558.1    Uniprot ID   -
Organism   Streptococcus mitis strain SK637     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 651696..662433
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SK637_RS03580 (SK637_00698) - 651778..652881 (+) 1104 WP_201798904.1 glycosyltransferase -
  SK637_RS03585 (SK637_00699) - 652883..653869 (+) 987 WP_033688553.1 glycosyltransferase family 2 protein -
  SK637_RS03590 (SK637_00700) - 653885..655354 (+) 1470 WP_033688555.1 O-antigen polysaccharide polymerase Wzy family protein -
  SK637_RS03595 (SK637_00701) - 655347..656381 (+) 1035 WP_033688557.1 hypothetical protein -
  SK637_RS03605 (SK637_00702) mecA 656696..657433 (+) 738 WP_033688558.1 adaptor protein MecA Regulator
  SK637_RS03610 (SK637_00703) - 657583..658869 (+) 1287 WP_033688560.1 homoserine dehydrogenase -
  SK637_RS03615 (SK637_00704) thrB 658871..659740 (+) 870 WP_033688562.1 homoserine kinase -
  SK637_RS03620 (SK637_00705) msrB 659954..660892 (+) 939 WP_033688564.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28406.22 Da        Isoelectric Point: 4.0520

>NTDB_id=284700 SK637_RS03605 WP_033688558.1 656696..657433(+) (mecA) [Streptococcus mitis strain SK637]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVSFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLINHDAVLN
LKKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=284700 SK637_RS03605 WP_033688558.1 656696..657433(+) (mecA) [Streptococcus mitis strain SK637]
ATGAAAATGAAACAAATTAGTGATACAACTTTGAAAATCACGATGTCTTTAGAGGATTTAATGGATCGTGGCATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGTTAGAGATGCCTGATAGCT
TTCTAGATACAGGTATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTCGATGTCTTTGTAACCAAATCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAACTAGCCCAAATGTCACCAGATGAATTTAT
CAAAACCTTGGAAAAAAGCATCGCGGACAAAACTAAGGATGATATCGAAGCCATTCAATCTCTAGAGCAAGTTGAAGCTA
AGGAAGAAGAGCAGGAGCAGGCTGAACAAGAAGCTGAGAGCAAGAAAGAGCCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTGTCTTTTGCTAAGACAGTGACTTTTGAGATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGTCCATATCCAGCGTGGCTTTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATTAGTCGTTCAGTCTTGCAGGAGTATGGTCAAGTCTTGATCAATCACGATGCAGTGCTTAAT
CTGAAAAAGATTGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

97.959

100

0.98
  mecA Streptococcus pneumoniae D39

97.959

100

0.98
  mecA Streptococcus pneumoniae R6

97.959

100

0.98
  mecA Streptococcus pneumoniae TIGR4

97.551

100

0.976
  mecA Streptococcus mutans UA159

48.163

100

0.482
  mecA Streptococcus thermophilus LMD-9

47.347

100

0.473
  mecA Streptococcus thermophilus LMG 18311

46.939

100

0.469

Multiple sequence alignment