Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SK637_RS01875 Genome accession   NZ_CP028415
Coordinates   357806..358543 (+) Length   245 a.a.
NCBI ID   WP_033688152.1    Uniprot ID   -
Organism   Streptococcus mitis strain SK637     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 352806..363543
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SK637_RS01845 (SK637_00361) - 353846..354505 (-) 660 WP_033688146.1 hypothetical protein -
  SK637_RS01850 (SK637_00362) - 354566..354853 (-) 288 WP_033688147.1 hypothetical protein -
  SK637_RS01855 (SK637_00363) - 354863..355273 (-) 411 WP_033688148.1 HIT family protein -
  SK637_RS01860 (SK637_00364) pptA 355341..356072 (+) 732 WP_033688149.1 ABC transporter ATP-binding protein Regulator
  SK637_RS01865 (SK637_00365) - 356069..357118 (+) 1050 WP_033688150.1 ABC transporter permease -
  SK637_RS01870 (SK637_00366) - 357181..357510 (-) 330 WP_004261043.1 hypothetical protein -
  SK637_RS01875 (SK637_00367) comE/blpR 357806..358543 (+) 738 WP_033688152.1 response regulator transcription factor Regulator
  SK637_RS01880 (SK637_00368) - 358557..359906 (+) 1350 WP_033688153.1 sensor histidine kinase -
  SK637_RS01900 (SK637_00370) - 361183..361587 (+) 405 WP_004257547.1 hypothetical protein -
  SK637_RS01905 (SK637_00371) - 361671..362054 (+) 384 WP_033688156.1 hypothetical protein -
  SK637_RS01910 (SK637_00372) blpZ 362091..362339 (+) 249 WP_033688157.1 immunity protein BlpZ -
  SK637_RS01915 (SK637_00373) - 362370..362981 (+) 612 WP_033688158.1 CPBP family intramembrane glutamic endopeptidase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28738.95 Da        Isoelectric Point: 6.3923

>NTDB_id=284694 SK637_RS01875 WP_033688152.1 357806..358543(+) (comE/blpR) [Streptococcus mitis strain SK637]
MRIFVLEDDFSQQTRIEATIEKLLKEHQIIPSSFAVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLFFPNGGSCMIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=284694 SK637_RS01875 WP_033688152.1 357806..358543(+) (comE/blpR) [Streptococcus mitis strain SK637]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAGCAGACTAGGATTGAAGCGACGATTGAGAAACTTTTGAAGGAACA
TCAGATTATTCCCAGCTCTTTTGCGGTCTTTGGTAAGCCAGATCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCAGAGTTTATGCCCCTGTCTTTTCGCTATCAAGTGTCCGCTTTGGA
CTACATTGATAAGGCCTTGTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTTCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTATTAT
CTTGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGACTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTAGTTCGTTTGGATA
AGAAAGAGAAACTCCTTTTCTTTCCTAATGGCGGAAGCTGTATGATAGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATCAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

42.616

96.735

0.412
  comE/comE2 Streptococcus equinus JB1

39.256

98.776

0.388
  comE Streptococcus infantis strain Atu-4

36.179

100

0.363

Multiple sequence alignment