Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP   Type   Regulator
Locus tag   SM12261_RS07370 Genome accession   NZ_CP028414
Coordinates   1455798..1457711 (-) Length   637 a.a.
NCBI ID   WP_000614511.1    Uniprot ID   -
Organism   Streptococcus mitis NCTC 12261     
Function   require for competence development; phosphorylate ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1450798..1462711
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM12261_RS07340 (SM12261_1418) - 1450833..1451798 (+) 966 WP_000225997.1 LacI family DNA-binding transcriptional regulator -
  SM12261_RS07350 (SM12261_1419) - 1451939..1453214 (-) 1276 Protein_1325 hydroxymethylglutaryl-CoA reductase, degradative -
  SM12261_RS07355 (SM12261_1421) - 1453214..1454386 (-) 1173 WP_000151944.1 hydroxymethylglutaryl-CoA synthase -
  SM12261_RS07360 (SM12261_1422) - 1454500..1454949 (-) 450 WP_004239205.1 threonine/serine exporter family protein -
  SM12261_RS07365 (SM12261_1423) - 1454951..1455709 (-) 759 WP_000392943.1 threonine/serine exporter family protein -
  SM12261_RS07370 (SM12261_1424) stkP 1455798..1457711 (-) 1914 WP_000614511.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  SM12261_RS07375 (SM12261_1425) - 1457708..1458448 (-) 741 WP_000406256.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  SM12261_RS07380 (SM12261_1426) rsmB 1458463..1459776 (-) 1314 WP_004239203.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  SM12261_RS07385 (SM12261_1427) fmt 1459769..1460704 (-) 936 WP_000163673.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 637 a.a.        Molecular weight: 69868.46 Da        Isoelectric Point: 9.3808

>NTDB_id=284653 SM12261_RS07370 WP_000614511.1 1455798..1457711(-) (stkP) [Streptococcus mitis NCTC 12261]
MIQIGKIFAGRYRILKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEEGQQYLAMEYVAGLDLKRYIKEHHPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSVIAENPSVP
QALENVVIKATAKKLTDRYKSVAEMYVDLSSSLSYNRRNEPKLVFDDATKADTKTLPKVPQSTLTSIPKAPVQEGRPQPK
PQPHQTEKTVPSSKPTKRRRMKARYPILFATFLLVVASLVWILYRTPATIAIPNVAGQTVAEAKEALKKANFEVGEEKSE
SSDKVEEGRVIRTDPEAGKTRKEGTKINLIVSSGQQSFQLGNYLGRKSSDVVAELKGKKVPENLIKIEEEESNEIEAGTI
MKQSLPEGTTYDLSKATQIVLTVAKKVNSISMPSYIGSSREFAVNNLTEIYDIKKANIEVVEVSKAPEGTAEGTVIEQSP
KAGEKVDLSTTRVKISIYKPKTPPSSSSSTSVQRGNQGSPTTPNQGNQQGGQQGNQQGTVPTPSQPNSEGNHENSRD

Nucleotide


Download         Length: 1914 bp        

>NTDB_id=284653 SM12261_RS07370 WP_000614511.1 1455798..1457711(-) (stkP) [Streptococcus mitis NCTC 12261]
ATGATCCAAATCGGCAAGATTTTTGCCGGGCGGTATCGGATTCTCAAACAGATTGGTCGAGGAGGCATGGCAGATGTTTA
CTTGGCTAAAGATTTGATTCTAGACGGGGAAGAAGTGGCAGTAAAGGTCCTGAGAACCAACTACCAGACAGACCCGATTG
CTGTGGCGCGTTTCCAGCGGGAAGCGAGAGCCATGGCGGATCTGGACCATCCTCATATCGTTCGGATTACAGATATCGGT
GAAGAAGAGGGACAACAGTATCTTGCAATGGAATATGTTGCTGGATTAGACCTCAAACGCTATATCAAGGAACATCACCC
TCTTTCAAATGAAGAAGCGGTTCGAATCATGGGACAAATCCTCTTGGCTATGCGCTTAGCCCATACTCGAGGAATTGTTC
ACAGGGATTTGAAACCGCAAAATATCCTTTTGACCCCAGATGGGACTGCCAAGGTTACAGACTTTGGGATTGCAGTAGCC
TTTGCAGAGACGAGTTTGACTCAGACCAACTCAATGCTGGGTTCCGTTCATTATTTATCGCCAGAGCAGGCGCGTGGTTC
TAAAGCAACTGTGCAGAGTGATATCTATGCCATGGGGATTATTTTCTATGAGATGCTGACAGGTCATATTCCTTACGATG
GGGATAGTGCGGTAACCATCGCCCTCCAGCATTTCCAGAAACCTCTGCCGTCGGTTATAGCTGAAAATCCATCTGTGCCT
CAGGCATTAGAAAATGTTGTTATCAAGGCAACTGCTAAGAAATTAACAGATCGTTACAAATCAGTCGCTGAAATGTATGT
GGATTTGTCGAGTAGTTTGTCTTATAATCGTCGTAATGAACCAAAGCTAGTCTTTGACGATGCAACTAAGGCAGATACTA
AAACTCTTCCTAAAGTACCGCAAAGTACCTTGACTTCTATTCCTAAAGCTCCGGTACAAGAGGGAAGACCTCAACCTAAG
CCCCAACCTCATCAGACAGAAAAAACAGTACCTAGTTCAAAGCCAACCAAACGTCGTCGTATGAAAGCACGTTATCCAAT
TTTATTTGCGACCTTCTTGTTGGTTGTGGCATCCTTGGTATGGATTTTATATAGAACGCCCGCTACCATTGCTATTCCAA
ATGTGGCAGGTCAGACGGTTGCAGAGGCTAAAGAGGCTCTAAAAAAAGCCAATTTTGAGGTTGGTGAAGAAAAATCAGAG
TCCAGTGATAAGGTTGAAGAAGGTCGGGTTATTCGTACAGACCCTGAAGCTGGTAAAACACGTAAAGAAGGAACAAAAAT
TAATTTGATTGTGTCTTCTGGTCAGCAGTCTTTCCAACTCGGAAATTATCTCGGAAGAAAGTCCAGTGATGTAGTGGCAG
AATTGAAGGGTAAGAAGGTTCCAGAAAATCTGATTAAGATTGAGGAAGAAGAATCCAACGAAATCGAAGCCGGTACAATC
ATGAAACAAAGTTTACCGGAGGGAACAACCTATGATCTTAGCAAGGCAACTCAAATAGTTTTGACAGTTGCTAAAAAAGT
AAATTCTATTTCAATGCCAAGCTATATTGGTTCTAGCCGAGAATTTGCAGTCAATAATCTTACAGAGATATATGACATTA
AAAAAGCTAATATCGAAGTTGTAGAAGTGTCTAAAGCTCCTGAAGGAACTGCTGAGGGGACTGTTATAGAGCAAAGTCCA
AAAGCAGGCGAAAAAGTAGACTTGAGCACTACTCGTGTTAAAATTTCTATTTATAAACCCAAAACACCACCATCAAGTTC
CTCTTCAACGTCAGTTCAACGTGGTAACCAAGGTTCACCTACTACTCCAAATCAAGGGAATCAACAAGGTGGCCAGCAAG
GAAATCAACAAGGAACGGTTCCTACTCCGAGTCAACCAAATAGTGAAGGAAATCACGAAAATTCTCGTGATTAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(511-579)

Protein kinase domain (Pkinase)

(12-227)

PASTA domain (PASTA)

(371-432)

PASTA domain (PASTA)

(442-505)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP Streptococcus pneumoniae TIGR4

78.462

91.837

0.721
  stkP Streptococcus pneumoniae D39

78.12

91.837

0.717
  stkP Streptococcus pneumoniae R6

78.12

91.837

0.717
  stkP Streptococcus pneumoniae Rx1

77.949

91.837

0.716
  stkP/pknB Streptococcus salivarius strain HSISS4

54.778

91.994

0.504
  pknB Streptococcus mutans UA159

55.44

90.895

0.504

Multiple sequence alignment