Detailed information
Bioinformatically predicted
Overview
| Name | mecA | Type | Regulator |
| Locus tag | SM12261_RS03520 | Genome accession | NZ_CP028414 |
| Coordinates | 651102..651839 (+) | Length | 245 a.a. |
| NCBI ID | WP_000782682.1 | Uniprot ID | A0AAX2L652 |
| Organism | Streptococcus mitis NCTC 12261 | ||
| Function | degradation of ComW (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 638459..693605 | 651102..651839 | within | 0 |
Gene organization within MGE regions
Location: 638459..693605
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SM12261_RS03460 (SM12261_0669) | aroC | 638712..639878 (+) | 1167 | WP_001269850.1 | chorismate synthase | - |
| SM12261_RS03465 (SM12261_0670) | - | 639888..640991 (+) | 1104 | WP_001140859.1 | prephenate dehydrogenase | - |
| SM12261_RS03470 (SM12261_0671) | - | 641002..641340 (+) | 339 | WP_000065969.1 | YlbF/YmcA family competence regulator | - |
| SM12261_RS03475 (SM12261_0672) | aroA | 641432..642715 (+) | 1284 | WP_004238699.1 | 3-phosphoshikimate 1-carboxyvinyltransferase | - |
| SM12261_RS03480 (SM12261_0673) | - | 642708..643184 (+) | 477 | WP_001151349.1 | shikimate kinase | - |
| SM12261_RS03485 (SM12261_0674) | pheA | 643181..644029 (+) | 849 | WP_000686445.1 | prephenate dehydratase | - |
| SM12261_RS03490 (SM12261_0675) | - | 644026..645336 (+) | 1311 | WP_000032338.1 | LCP family protein | - |
| SM12261_RS03495 (SM12261_0676) | - | 645457..646302 (+) | 846 | WP_001061995.1 | LicD family protein | - |
| SM12261_RS03500 (SM12261_0677) | - | 646292..647395 (+) | 1104 | WP_000225887.1 | glycosyltransferase | - |
| SM12261_RS03505 (SM12261_0678) | - | 647397..648383 (+) | 987 | WP_000446965.1 | glycosyltransferase family 2 protein | - |
| SM12261_RS03510 (SM12261_0679) | - | 648399..649868 (+) | 1470 | WP_004238693.1 | O-antigen polysaccharide polymerase Wzy family protein | - |
| SM12261_RS03515 (SM12261_0680) | - | 649861..650895 (+) | 1035 | WP_000461491.1 | hypothetical protein | - |
| SM12261_RS03520 (SM12261_0681) | mecA | 651102..651839 (+) | 738 | WP_000782682.1 | adaptor protein MecA | Regulator |
| SM12261_RS03525 (SM12261_0682) | - | 651991..653277 (+) | 1287 | WP_000216346.1 | homoserine dehydrogenase | - |
| SM12261_RS03530 (SM12261_0683) | thrB | 653279..654148 (+) | 870 | WP_000692425.1 | homoserine kinase | - |
| SM12261_RS03535 (SM12261_0684) | msrB | 654361..655299 (+) | 939 | WP_000818182.1 | peptide-methionine (R)-S-oxide reductase MsrB | - |
| SM12261_RS03540 (SM12261_0685) | - | 655360..657084 (+) | 1725 | WP_000681728.1 | ABC transporter ATP-binding protein | - |
| SM12261_RS03545 (SM12261_0686) | - | 657086..658834 (+) | 1749 | WP_001254284.1 | ABC transporter ATP-binding protein | - |
| SM12261_RS03550 (SM12261_0687) | - | 659092..660351 (+) | 1260 | WP_000870440.1 | TRZ/ATZ family protein | - |
| SM12261_RS03560 (SM12261_0688) | rplJ | 660602..661102 (+) | 501 | WP_001287267.1 | 50S ribosomal protein L10 | - |
| SM12261_RS03565 (SM12261_0689) | rplL | 661175..661543 (+) | 369 | WP_001196965.1 | 50S ribosomal protein L7/L12 | - |
| SM12261_RS03570 (SM12261_0691) | pezA | 662071..662547 (+) | 477 | WP_000579609.1 | type II toxin-antitoxin system antitoxin PezA | - |
| SM12261_RS03575 (SM12261_0692) | pezT | 662547..663317 (+) | 771 | WP_000405376.1 | type II toxin-antitoxin system toxin PezT | - |
| SM12261_RS03585 (SM12261_0695) | - | 664974..665405 (+) | 432 | WP_025169729.1 | hypothetical protein | - |
| SM12261_RS03590 (SM12261_0696) | - | 665408..665797 (+) | 390 | Protein_615 | replication initiation factor domain-containing protein | - |
| SM12261_RS03595 (SM12261_0697) | - | 665960..666430 (+) | 471 | WP_000447038.1 | MarR family transcriptional regulator | - |
| SM12261_RS03600 (SM12261_0698) | - | 666430..668706 (+) | 2277 | WP_000401876.1 | ATP-binding cassette domain-containing protein | - |
| SM12261_RS03605 (SM12261_0699) | - | 669158..669490 (+) | 333 | WP_000656278.1 | LytTR family DNA-binding domain-containing protein | - |
| SM12261_RS03610 (SM12261_0700) | comE/blpR | 669501..670241 (+) | 741 | WP_001019941.1 | response regulator transcription factor | Regulator |
| SM12261_RS03615 (SM12261_0701) | - | 670470..671615 (+) | 1146 | WP_000209246.1 | low temperature requirement protein A | - |
| SM12261_RS03620 | - | 671912..671980 (+) | 69 | WP_373852502.1 | Maff2 family mobile element protein | - |
| SM12261_RS03625 (SM12261_0702) | - | 672305..672988 (+) | 684 | WP_000492701.1 | LexA family transcriptional regulator | - |
| SM12261_RS03630 (SM12261_0703) | - | 672991..674406 (+) | 1416 | WP_000219659.1 | Y-family DNA polymerase | - |
| SM12261_RS03635 | - | 674403..674768 (+) | 366 | WP_000981959.1 | hypothetical protein | - |
| SM12261_RS03640 | - | 674758..675048 (+) | 291 | WP_001080187.1 | DUF5960 family protein | - |
| SM12261_RS03645 (SM12261_0704) | - | 675343..675702 (+) | 360 | WP_000529547.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| SM12261_RS03650 (SM12261_0705) | mobC | 675712..676077 (+) | 366 | WP_000263039.1 | plasmid mobilization relaxosome protein MobC | - |
| SM12261_RS03655 (SM12261_0706) | - | 676064..677926 (+) | 1863 | WP_000261797.1 | SAG1250 family conjugative relaxase | - |
| SM12261_RS03660 (SM12261_0707) | - | 677970..678818 (-) | 849 | WP_000837479.1 | helix-turn-helix domain-containing protein | - |
| SM12261_RS09675 | - | 679171..679386 (+) | 216 | WP_265094651.1 | ATP-binding cassette domain-containing protein | - |
| SM12261_RS03670 (SM12261_0708) | - | 679379..679813 (+) | 435 | WP_135781820.1 | ATP-binding cassette domain-containing protein | - |
| SM12261_RS09480 (SM12261_0709) | - | 679826..679996 (+) | 171 | WP_000711945.1 | hypothetical protein | - |
| SM12261_RS03680 (SM12261_0710) | gdhA | 680277..681623 (-) | 1347 | WP_000199543.1 | NADP-specific glutamate dehydrogenase | - |
| SM12261_RS03685 (SM12261_0711) | - | 681864..682799 (+) | 936 | WP_000255154.1 | dihydroorotate oxidase | - |
| SM12261_RS03690 (SM12261_0712) | holA | 682833..683870 (+) | 1038 | WP_135781821.1 | DNA polymerase III subunit delta | - |
| SM12261_RS03700 (SM12261_0714) | sodA | 684241..684846 (+) | 606 | WP_000974733.1 | superoxide dismutase SodA | - |
| SM12261_RS03705 (SM12261_0715) | - | 685008..685538 (+) | 531 | WP_001224347.1 | YutD family protein | - |
| SM12261_RS03710 (SM12261_0716) | rlmN | 685559..686644 (+) | 1086 | WP_000804766.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| SM12261_RS03715 (SM12261_0717) | - | 686644..687126 (+) | 483 | WP_000976729.1 | VanZ family protein | - |
| SM12261_RS03720 (SM12261_0718) | - | 687128..688669 (+) | 1542 | WP_000025380.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| SM12261_RS03725 (SM12261_0719) | - | 688723..689526 (-) | 804 | WP_000717398.1 | peptidylprolyl isomerase | - |
| SM12261_RS03730 (SM12261_0720) | - | 689831..690055 (-) | 225 | WP_001041099.1 | helix-turn-helix transcriptional regulator | - |
| SM12261_RS03735 (SM12261_0721) | - | 690058..690636 (-) | 579 | WP_000742118.1 | hypothetical protein | - |
| SM12261_RS09485 (SM12261_0722) | - | 690897..691040 (-) | 144 | WP_001067872.1 | hypothetical protein | - |
| SM12261_RS03740 (SM12261_0723) | rpsP | 691216..691488 (+) | 273 | WP_000268760.1 | 30S ribosomal protein S16 | - |
| SM12261_RS03745 (SM12261_0724) | kphA | 691508..691747 (+) | 240 | WP_000379617.1 | RNA-binding protein KphA | - |
| SM12261_RS03750 (SM12261_0725) | - | 691861..692412 (+) | 552 | WP_004239319.1 | hypothetical protein | - |
| SM12261_RS03755 (SM12261_0726) | - | 692520..693308 (+) | 789 | WP_000821028.1 | alpha/beta fold hydrolase | - |
Sequence
Protein
Download Length: 245 a.a. Molecular weight: 28406.18 Da Isoelectric Point: 4.0236
>NTDB_id=284634 SM12261_RS03520 WP_000782682.1 651102..651839(+) (mecA) [Streptococcus mitis NCTC 12261]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEGESKKEPYIYYILSFS
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFAEDSDISRSVLQEYGQVLLNHDAVLN
LQKIG
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEGESKKEPYIYYILSFS
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFAEDSDISRSVLQEYGQVLLNHDAVLN
LQKIG
Nucleotide
Download Length: 738 bp
>NTDB_id=284634 SM12261_RS03520 WP_000782682.1 651102..651839(+) (mecA) [Streptococcus mitis NCTC 12261]
ATGAAAATGAAACAAATCAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGAGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGTTAGAGATGCCTGATAGCT
TCCTAGATACAGGTATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTAACCAAATCAAAGATT
GATCAAAATCTAGATTTTGAAGATTTATCGGATTTACCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCTTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCGATTCAATCTCTAGAGCAGGTTGAAGCCA
AGGAGGAAGAGCAAGAGCAGGCTGAACAAGAAGGTGAAAGCAAGAAAGAGCCGTACATCTATTACATCCTTTCTTTTTCT
AAGTTAGCTGACTTGGTGGCTTTTGCCAAGACAGTGACTTTTGAGATGGAAACTTCTGAACTCTACAAGATGAATGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGTCCATATCCAGCTTGGCTCTTGGCCCGTATGCGCGAGT
TTGCGGAAGATAGTGATATCAGTCGTTCAGTCTTGCAAGAGTATGGCCAAGTCTTGCTGAATCACGATGCAGTGCTCAAT
CTGCAAAAGATTGGATAA
ATGAAAATGAAACAAATCAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGAGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGTTAGAGATGCCTGATAGCT
TCCTAGATACAGGTATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTAACCAAATCAAAGATT
GATCAAAATCTAGATTTTGAAGATTTATCGGATTTACCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCTTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCGATTCAATCTCTAGAGCAGGTTGAAGCCA
AGGAGGAAGAGCAAGAGCAGGCTGAACAAGAAGGTGAAAGCAAGAAAGAGCCGTACATCTATTACATCCTTTCTTTTTCT
AAGTTAGCTGACTTGGTGGCTTTTGCCAAGACAGTGACTTTTGAGATGGAAACTTCTGAACTCTACAAGATGAATGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGTCCATATCCAGCTTGGCTCTTGGCCCGTATGCGCGAGT
TTGCGGAAGATAGTGATATCAGTCGTTCAGTCTTGCAAGAGTATGGCCAAGTCTTGCTGAATCACGATGCAGTGCTCAAT
CTGCAAAAGATTGGATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| mecA | Streptococcus pneumoniae Rx1 |
97.551 |
100 |
0.976 |
| mecA | Streptococcus pneumoniae D39 |
97.551 |
100 |
0.976 |
| mecA | Streptococcus pneumoniae R6 |
97.551 |
100 |
0.976 |
| mecA | Streptococcus pneumoniae TIGR4 |
97.143 |
100 |
0.971 |
| mecA | Streptococcus mutans UA159 |
49.187 |
100 |
0.494 |
| mecA | Streptococcus thermophilus LMD-9 |
46.586 |
100 |
0.473 |
| mecA | Streptococcus thermophilus LMG 18311 |
46.185 |
100 |
0.469 |