Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SM12261_RS03520 Genome accession   NZ_CP028414
Coordinates   651102..651839 (+) Length   245 a.a.
NCBI ID   WP_000782682.1    Uniprot ID   A0AAX2L652
Organism   Streptococcus mitis NCTC 12261     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 646102..656839
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM12261_RS03500 (SM12261_0677) - 646292..647395 (+) 1104 WP_000225887.1 glycosyltransferase -
  SM12261_RS03505 (SM12261_0678) - 647397..648383 (+) 987 WP_000446965.1 glycosyltransferase family 2 protein -
  SM12261_RS03510 (SM12261_0679) - 648399..649868 (+) 1470 WP_004238693.1 O-antigen polysaccharide polymerase Wzy family protein -
  SM12261_RS03515 (SM12261_0680) - 649861..650895 (+) 1035 WP_000461491.1 hypothetical protein -
  SM12261_RS03520 (SM12261_0681) mecA 651102..651839 (+) 738 WP_000782682.1 adaptor protein MecA Regulator
  SM12261_RS03525 (SM12261_0682) - 651991..653277 (+) 1287 WP_000216346.1 homoserine dehydrogenase -
  SM12261_RS03530 (SM12261_0683) thrB 653279..654148 (+) 870 WP_000692425.1 homoserine kinase -
  SM12261_RS03535 (SM12261_0684) msrB 654361..655299 (+) 939 WP_000818182.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28406.18 Da        Isoelectric Point: 4.0236

>NTDB_id=284634 SM12261_RS03520 WP_000782682.1 651102..651839(+) (mecA) [Streptococcus mitis NCTC 12261]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEGESKKEPYIYYILSFS
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFAEDSDISRSVLQEYGQVLLNHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=284634 SM12261_RS03520 WP_000782682.1 651102..651839(+) (mecA) [Streptococcus mitis NCTC 12261]
ATGAAAATGAAACAAATCAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGAGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGTTAGAGATGCCTGATAGCT
TCCTAGATACAGGTATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTAACCAAATCAAAGATT
GATCAAAATCTAGATTTTGAAGATTTATCGGATTTACCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCTTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCGATTCAATCTCTAGAGCAGGTTGAAGCCA
AGGAGGAAGAGCAAGAGCAGGCTGAACAAGAAGGTGAAAGCAAGAAAGAGCCGTACATCTATTACATCCTTTCTTTTTCT
AAGTTAGCTGACTTGGTGGCTTTTGCCAAGACAGTGACTTTTGAGATGGAAACTTCTGAACTCTACAAGATGAATGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGTCCATATCCAGCTTGGCTCTTGGCCCGTATGCGCGAGT
TTGCGGAAGATAGTGATATCAGTCGTTCAGTCTTGCAAGAGTATGGCCAAGTCTTGCTGAATCACGATGCAGTGCTCAAT
CTGCAAAAGATTGGATAA

Domains

Predicted by InterProScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

97.551

100

0.976
  mecA Streptococcus pneumoniae D39

97.551

100

0.976
  mecA Streptococcus pneumoniae R6

97.551

100

0.976
  mecA Streptococcus pneumoniae TIGR4

97.143

100

0.971
  mecA Streptococcus mutans UA159

49.187

100

0.494
  mecA Streptococcus thermophilus LMD-9

46.586

100

0.473
  mecA Streptococcus thermophilus LMG 18311

46.185

100

0.469

Multiple sequence alignment