Detailed information NTG0283731

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: EFD52_RS00355
• Genome accession: NZ_CP033606
• Coordinates: 67647..69794 (+)
• Length: 715 a.a.
• NCBI ID: WP_010905094.1
• Uniprot ID: Q9CJB8
• Organism: Lactococcus lactis strain IL6288
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 62647..74794

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EFD52_RS00330 (EFD52_00330)	-	63784..64251 (+)	468	WP_010905090.1	universal stress protein	-
EFD52_RS00335 (EFD52_00335)	-	64380..64577 (+)	198	WP_010905091.1	DUF4649 domain-containing protein	-
EFD52_RS00340 (EFD52_00340)	-	64608..65228 (+)	621	WP_010905092.1	alpha/beta hydrolase	-
EFD52_RS00345 (EFD52_00345)	-	65279..66448 (+)	1170	WP_010905093.1	ring-cleaving dioxygenase	-
EFD52_RS00350 (EFD52_00350)	-	66459..67049 (+)	591	WP_003132255.1	flavin reductase family protein	-
EFD52_RS00355 (EFD52_00355)	comA	67647..69794 (+)	2148	WP_010905094.1	peptide cleavage/export ABC transporter	Regulator
EFD52_RS00360 (EFD52_00360)	-	69809..71230 (+)	1422	WP_010905095.1	HlyD family secretion protein	-
EFD52_RS00365 (EFD52_00365)	-	71324..71449 (+)	126	WP_021214955.1	lactococcin family bacteriocin	-
EFD52_RS00370 (EFD52_00370)	-	71775..72143 (+)	369	WP_223848592.1	transporter	-
EFD52_RS00375 (EFD52_00375)	-	72182..72838 (+)	657	WP_021214956.1	type II CAAX endopeptidase family protein	-
EFD52_RS00380 (EFD52_00380)	-	72941..73222 (-)	282	WP_010905098.1	hypothetical protein	-
EFD52_RS00385 (EFD52_00385)	-	73232..73384 (-)	153	WP_010905099.1	hypothetical protein	-
EFD52_RS00395 (EFD52_00395)	-	74035..74172 (+)	138	WP_021214958.1	lactococcin family bacteriocin	-

Sequence

Protein

• Length: 715 a.a.
• Molecular weight: 79865.43 Da
• Isoelectric Point: 8.6006

>NTDB_id=283731 EFD52_RS00355 WP_010905094.1 67647..69794(+) (comA) [Lactococcus lactis strain IL6288]
MKFKKKNYTSQVDEMDCGCAALSMILKSYGTEKSLASLRLLAGTTIEGTSALGIKKAGEGLGFVVQVLRADASLFEMKKV
PYPFIAHVIKNQKYPHYYVITGANKNSVFIADPDPTVKMTKLSKEVFLSEWTGISLFLSPTPSYQPTKEKTSSLLSFIPI
ITRQKKVILNIVIASFIVTLINILGSYYLQSMIDSYIPNALMGTLGIISVGLLLTYIIQQVLEFAKAFLLNVLSQRLAID
VILSYIRHIFQLPMSFFSTRRTGEITSRFSDASSILDAIASTILSLFLDLTIVLMTGLILGLQNMQLFLLVLLAIPLYIV
VIIIFTPLFERQNHEVMQTNAILNSSIIEDINGIETIKALASEQERYQKIDYEFASYLKEAFTLQQSEAIQTAIKTTVQL
VLNVLILWFGATLVMHQKITLGQLITFNALLSYFTNPITNIINLQTKLQKARVANERLNEVYLVPSEFEEKKTELSLSHF
NLNMSEISYQYGFGRKVLSEIKLSIKENEKLTIVGISGSGKSTLVKLLVNFFQPTSGTITLGGIDLQQFDKHQLRRLINY
LPQQPYIFTGSIMDNLLLGASEATSQEEIIRAVELAEIRADIEQMQLGYQTELSSDASSLSGGQKQRIALARALLSPAKI
LILDEATSNLDMITEKKILKNLLALDKTIIFIAHRLSVAEMSHRIIVIEQGKVIESGSHSELLAQNGFYAQLYHN

Nucleotide

• Length: 2148 bp

>NTDB_id=283731 EFD52_RS00355 WP_010905094.1 67647..69794(+) (comA) [Lactococcus lactis strain IL6288]
ATGAAATTTAAAAAGAAAAATTATACCTCCCAAGTAGATGAAATGGATTGTGGATGTGCTGCTTTATCAATGATTTTAAA
ATCCTATGGGACAGAAAAATCGCTTGCCTCTCTTCGTTTACTTGCTGGTACAACAATCGAGGGAACTTCCGCTTTAGGAA
TAAAAAAAGCAGGAGAAGGTTTAGGTTTTGTAGTTCAAGTACTAAGAGCTGATGCAAGCCTTTTTGAAATGAAGAAAGTC
CCTTACCCTTTTATTGCTCATGTCATCAAGAACCAAAAGTATCCACACTACTATGTGATAACTGGCGCAAATAAAAATTC
GGTATTCATCGCAGATCCTGACCCAACCGTTAAAATGACAAAACTTTCAAAAGAAGTTTTCTTATCAGAGTGGACAGGCA
TTAGCTTATTTCTTTCACCTACCCCATCCTATCAGCCCACTAAAGAAAAAACTTCTTCATTATTATCTTTTATCCCAATT
ATCACCCGTCAAAAGAAAGTCATTCTCAATATTGTAATTGCCTCATTCATTGTAACGTTGATTAATATTCTAGGGTCTTA
CTACCTCCAGAGCATGATTGATAGTTACATTCCAAATGCCTTAATGGGAACTTTAGGGATTATCTCAGTAGGGCTATTGT
TAACTTATATTATCCAACAAGTCTTAGAGTTTGCTAAGGCTTTCTTACTAAACGTTCTTTCTCAAAGATTAGCCATTGAT
GTCATCCTTTCCTATATTAGACACATTTTCCAACTCCCGATGTCTTTCTTTTCGACTAGAAGAACAGGGGAAATTACCAG
TCGGTTTTCCGATGCCAGTTCTATTTTGGATGCTATTGCCTCAACGATTCTTTCGCTCTTTTTAGATTTAACCATTGTTC
TTATGACAGGACTGATTTTAGGGCTTCAAAATATGCAACTCTTTCTTCTCGTTCTTTTGGCAATCCCACTTTATATTGTT
GTTATTATTATTTTTACTCCGCTTTTTGAAAGACAAAATCATGAAGTTATGCAAACCAATGCCATCTTAAATTCCTCAAT
TATTGAAGACATTAATGGGATTGAAACCATCAAAGCGCTCGCCAGTGAACAAGAGAGATATCAAAAAATTGACTACGAAT
TTGCAAGTTATCTAAAAGAGGCTTTCACTTTACAACAGTCAGAAGCCATTCAGACGGCAATAAAAACGACAGTACAACTT
GTACTAAATGTTCTTATTTTATGGTTTGGTGCAACTTTAGTCATGCATCAAAAAATTACCCTCGGACAACTCATTACTTT
TAATGCCTTGCTTTCTTACTTTACAAATCCAATTACTAATATCATTAACCTTCAAACAAAACTACAAAAGGCAAGGGTAG
CCAATGAACGATTAAATGAGGTCTATCTTGTACCCAGTGAATTTGAAGAAAAGAAAACAGAACTGTCCCTCTCACATTTT
AATTTAAACATGTCTGAGATTTCATATCAATATGGTTTTGGCAGAAAAGTCTTATCTGAGATAAAACTGTCTATTAAAGA
AAATGAAAAGTTGACCATTGTTGGTATAAGCGGTTCAGGGAAGAGTACTCTTGTTAAATTATTGGTCAACTTCTTTCAAC
CCACTTCTGGTACCATTACTTTAGGTGGAATTGACCTTCAACAGTTTGATAAACATCAACTTCGACGATTAATCAACTAT
CTTCCCCAACAACCTTATATTTTCACAGGTTCAATTATGGATAATTTACTTTTAGGCGCTAGTGAAGCTACTTCACAAGA
AGAGATTATTAGAGCGGTGGAATTGGCAGAAATCCGTGCAGATATTGAACAAATGCAATTAGGTTATCAAACTGAACTCT
CAAGTGATGCAAGTAGTTTATCGGGAGGACAAAAACAGAGAATTGCGCTCGCTCGTGCCCTCCTTTCTCCTGCCAAAATA
CTCATCTTAGACGAAGCCACCAGTAATCTTGATATGATTACTGAAAAGAAAATATTAAAGAATTTGTTGGCACTAGATAA
GACAATTATTTTCATTGCTCACCGCCTCTCTGTAGCGGAAATGAGCCATCGTATCATTGTCATTGAACAAGGAAAAGTGA
TAGAAAGTGGTTCACATTCAGAACTGCTTGCTCAAAATGGCTTTTACGCACAACTTTACCATAACTAA

Domains

Predicted by InterProScan.

• ABC transporter transmembrane region (ABC_membrane) (169-437)

• ABC transporter (ABC_tran) (498-648)

• Peptidase C39 family (Peptidase_C39) (6-142)

3D structure

• AlphaFold DB: Q9CJB8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus gordonii str. Challis substr. CH1	61.204	99.86	0.611
comA	Streptococcus mitis NCTC 12261	60.224	99.86	0.601
comA	Streptococcus mitis SK321	60.084	99.86	0.6
comA	Streptococcus pneumoniae Rx1	59.804	99.86	0.597
comA	Streptococcus pneumoniae D39	59.804	99.86	0.597
comA	Streptococcus pneumoniae R6	59.804	99.86	0.597
comA	Streptococcus pneumoniae TIGR4	59.524	99.86	0.594
comA/nlmT	Streptococcus mutans UA159	58.774	100	0.59