Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   C5P47_RS00345 Genome accession   NZ_CP028140
Coordinates   55289..56200 (+) Length   303 a.a.
NCBI ID   WP_014635220.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NGAS979     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 50289..61200
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C5P47_RS00330 (C5P47_00320) - 52132..53244 (+) 1113 WP_032464126.1 DUF262 domain-containing protein -
  C5P47_RS00335 (C5P47_00325) - 53248..53856 (+) 609 WP_032464127.1 hypothetical protein -
  C5P47_RS00340 (C5P47_00330) purB 53866..55158 (+) 1293 WP_032464128.1 adenylosuccinate lyase -
  C5P47_RS00345 (C5P47_00335) comR 55289..56200 (+) 912 WP_014635220.1 XRE family transcriptional regulator Regulator
  C5P47_RS09095 comS 56291..56389 (+) 99 WP_020833188.1 quorum-sensing system DWW-type pheromone Regulator
  C5P47_RS00350 (C5P47_00340) ruvB 56420..57418 (+) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  C5P47_RS00355 (C5P47_00345) - 57556..57993 (+) 438 WP_002994668.1 low molecular weight phosphotyrosine protein phosphatase -
  C5P47_RS00360 (C5P47_00350) - 58016..58417 (+) 402 WP_012560369.1 MORN repeat-containing protein -
  C5P47_RS00365 (C5P47_00355) - 58414..60189 (+) 1776 WP_002994672.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35925.63 Da        Isoelectric Point: 4.9349

>NTDB_id=281561 C5P47_RS00345 WP_014635220.1 55289..56200(+) (comR) [Streptococcus pyogenes strain NGAS979]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLPLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide


Download         Length: 912 bp        

>NTDB_id=281561 C5P47_RS00345 WP_014635220.1 55289..56200(+) (comR) [Streptococcus pyogenes strain NGAS979]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTACCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS315

99.34

100

0.993
  comR Streptococcus pyogenes MGAS8232

58.472

99.34

0.581
  comR Streptococcus mutans UA159

47.492

98.68

0.469
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

46.441

97.36

0.452
  comR Streptococcus suis P1/7

37.374

98.02

0.366
  comR Streptococcus suis 05ZYH33

37.374

98.02

0.366

Multiple sequence alignment