Detailed information NTG0280422

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: C7K40_RS00330
• Genome accession: NZ_CP027771
• Coordinates: 53013..53924 (+)
• Length: 303 a.a.
• NCBI ID: WP_014635220.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain DMG1800716
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48013..58924

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C7K40_RS00310 (C7K40_00305)	purE	48318..48809 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
C7K40_RS00315 (C7K40_00310)	purK	48796..49869 (+)	1074	WP_063629570.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
C7K40_RS09780 (C7K40_00315)	-	49890..51219 (+)	1330	Protein_30	hypothetical protein	-
C7K40_RS00325 (C7K40_00320)	purB	51588..52880 (+)	1293	WP_023612869.1	adenylosuccinate lyase	-
C7K40_RS00330 (C7K40_00325)	comR	53013..53924 (+)	912	WP_014635220.1	XRE family transcriptional regulator	Regulator
C7K40_RS09545	comS	54015..54113 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
C7K40_RS00335 (C7K40_00330)	ruvB	54144..55142 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
C7K40_RS00340 (C7K40_00335)	-	55280..55717 (+)	438	WP_002994668.1	low molecular weight phosphotyrosine protein phosphatase	-
C7K40_RS00345 (C7K40_00340)	-	55740..56141 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
C7K40_RS00350 (C7K40_00345)	-	56138..57913 (+)	1776	WP_002986669.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35925.63 Da
• Isoelectric Point: 4.9349

>NTDB_id=280422 C7K40_RS00330 WP_014635220.1 53013..53924(+) (comR) [Streptococcus pyogenes strain DMG1800716]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLPLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=280422 C7K40_RS00330 WP_014635220.1 53013..53924(+) (comR) [Streptococcus pyogenes strain DMG1800716]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTACCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAGAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.492	98.68	0.469
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366