Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   LL223_RS11960 Genome accession   NZ_CP031926
Coordinates   2313345..2314571 (+) Length   408 a.a.
NCBI ID   WP_010906329.1    Uniprot ID   Q66RV0
Organism   Lactococcus lactis subsp. lactis strain 223     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2308345..2319571
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LL223_RS11930 (LL223_2283) - 2308358..2309161 (-) 804 WP_003130590.1 phosphatidate cytidylyltransferase -
  LL223_RS11935 (LL223_2284) - 2309161..2309895 (-) 735 WP_010906326.1 isoprenyl transferase -
  LL223_RS11940 (LL223_2285) yajC 2310267..2310599 (-) 333 WP_003130588.1 preprotein translocase subunit YajC -
  LL223_RS11945 (LL223_2286) - 2310694..2311391 (-) 698 Protein_2328 DNA alkylation repair protein -
  LL223_RS11950 (LL223_2287) rlmH 2311410..2311889 (-) 480 WP_003130585.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  LL223_RS11955 (LL223_2288) - 2311928..2312875 (-) 948 WP_003130410.1 IS30 family transposase -
  LL223_RS11960 (LL223_2289) htrA 2313345..2314571 (+) 1227 WP_010906329.1 S1C family serine protease Regulator
  LL223_RS11965 (LL223_2290) - 2314697..2315695 (+) 999 WP_010906330.1 glycosyltransferase family 4 protein -
  LL223_RS11970 (LL223_2291) - 2315821..2317161 (+) 1341 WP_010906331.1 glycosyltransferase family 4 protein -
  LL223_RS11975 (LL223_2292) - 2317269..2317493 (+) 225 WP_003130579.1 YkuJ family protein -
  LL223_RS11980 (LL223_2293) - 2317635..2318639 (+) 1005 WP_010906332.1 hypothetical protein -
  LL223_RS11985 (LL223_2294) - 2318680..2319432 (-) 753 WP_010906333.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -

Sequence

Protein


Download         Length: 408 a.a.        Molecular weight: 41647.97 Da        Isoelectric Point: 4.9794

>NTDB_id=273789 LL223_RS11960 WP_010906329.1 2313345..2314571(+) (htrA) [Lactococcus lactis subsp. lactis strain 223]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNS
QSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAV
LKISSEHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
GALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPS
SVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLE
TSSPSSSN

Nucleotide


Download         Length: 1227 bp        

>NTDB_id=273789 LL223_RS11960 WP_010906329.1 2313345..2314571(+) (htrA) [Lactococcus lactis subsp. lactis strain 223]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACAGGTGTCGTGGGCGGAGCCATCGCACTTGGAGGAAGTGCAATCTA
TCAAAGCACTACAAATCAATCGGCAAATAATAGTCGTTCAAATACAACTAGTACAAAGGTTAGTAACGTTTCGGTAAATG
TCAATACCGATGTTACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAAGATAACTCA
CAAAGTAGTGACTTCAGTTCAATTTTTGGTGGAAATAGCGGTTCAAGTTCATCGACTGATGGCTTACAGCTTTCTAGTGA
AGGCTCTGGTGTCATCTACAAAAAATCTGGTGGTGATGCCTACGTTGTAACTAACTACCACGTTATTGCTGGTAATAGCT
CACTTGATGTTCTGCTTTCTGGTGGACAAAAAGTCAAAGCTTCTGTGGTTGGTTATGATGAATACACAGACCTTGCTGTT
CTTAAAATCAGTTCTGAACATGTCAAAGATGTGGCGACATTCGCTGATTCTAGTAAATTAACAATTGGTGAACCTGCCAT
TGCCGTTGGCTCACCTTTAGGTAGTCAATTTGCAAACACCGCAACTGAAGGAATTTTATCTGCAACAAGCCGTCAAGTGA
CTTTGACCCAAGAAAATGGTCAAACAACTAATATCAATGCAATTCAAACAGATGCTGCCATTAACCCTGGTAACTCTGGA
GGGGCTTTGATTAATATTGAAGGACAAGTTATTGGAATTACTCAAAGTAAAATTACAACAACTGAAGATGGTTCTACTTC
TGTCGAAGGTTTAGGATTTGCGATTCCTTCTAATGATGTCGTAAATATCATTAATAAACTTGAAGCTGATGGTAAGATTT
CACGCCCTGCTTTAGGTATCCGAATGGTTGACCTTTCACAATTATCAACAAATGACAGTTCTCAATTGAAATTACCAAGC
AGTGTAACAGGTGGGGTTGTTGTTTACTCCGTCCAATCTGGACTTCCTGCTGCCTCAGCTGGTTTGAAAGCTGGAGATGT
AATTACAAAGGTTGGCGATACAGCAGTAACCTCTTCAACAGACTTGCAAAGTGCTCTTTACTCACACAATATCAATGATA
CAGTAAAAGTTACTTATTATCGTGATGGTAAATCAAATACAGCAGATGTTAAACTTTCTAAATCAACCAGTGACTTAGAA
ACAAGCAGTCCATCTTCTTCTAATTAA

Domains

Predicted by InterProScan.

PDZ domain (PDZ_2)

(296-392)

Peptidase family M50 (Peptidase_M50)

(260-396)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q66RV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

56.283

93.627

0.527
  htrA Streptococcus gordonii str. Challis substr. CH1

54.476

95.833

0.522
  htrA Streptococcus pneumoniae D39

58.309

84.069

0.49
  htrA Streptococcus pneumoniae TIGR4

58.309

84.069

0.49
  htrA Streptococcus pneumoniae R6

58.309

84.069

0.49
  htrA Streptococcus pneumoniae Rx1

58.309

84.069

0.49
  htrA Streptococcus mutans UA159

52.989

90.196

0.478

Multiple sequence alignment