Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   C4N11_RS04565 Genome accession   NZ_CP026670
Coordinates   854462..856702 (+) Length   746 a.a.
NCBI ID   WP_000942392.1    Uniprot ID   A0A6I3VL05
Organism   Streptococcus pneumoniae strain endophthalmitis isolate 335     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 849462..861702
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C4N11_RS04520 (C4N11_04520) - 849612..850580 (+) 969 WP_000658183.1 PhoH family protein -
  C4N11_RS04525 (C4N11_04525) - 850558..850737 (-) 180 WP_001813350.1 hypothetical protein -
  C4N11_RS04530 (C4N11_04530) - 850773..851274 (+) 502 Protein_850 GNAT family N-acetyltransferase -
  C4N11_RS04535 (C4N11_04535) - 851277..851603 (+) 327 Protein_851 TfoX/Sxy family protein -
  C4N11_RS12555 ald 851904..853014 (-) 1111 Protein_852 alanine dehydrogenase -
  C4N11_RS04555 (C4N11_04555) - 853191..853760 (+) 570 WP_000443777.1 GNAT family N-acetyltransferase -
  C4N11_RS04560 (C4N11_04560) comEA/celA/cilE 853828..854478 (+) 651 WP_000387328.1 ComEA family DNA-binding protein Machinery gene
  C4N11_RS04565 (C4N11_04565) comEC/celB 854462..856702 (+) 2241 WP_000942392.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  C4N11_RS12560 (C4N11_04570) - 856844..857068 (+) 225 WP_000583432.1 hypothetical protein -
  C4N11_RS04575 (C4N11_04575) - 857101..857688 (+) 588 WP_000939884.1 ATP-binding cassette domain-containing protein -
  C4N11_RS04580 (C4N11_04580) - 857692..858873 (+) 1182 WP_000655951.1 membrane protein -
  C4N11_RS04585 (C4N11_04585) infC 859180..859710 (+) 531 WP_000848180.1 translation initiation factor IF-3 -
  C4N11_RS04590 (C4N11_04590) rpmI 859743..859943 (+) 201 WP_001125943.1 50S ribosomal protein L35 -
  C4N11_RS04595 (C4N11_04595) rplT 859995..860354 (+) 360 WP_000124836.1 50S ribosomal protein L20 -
  C4N11_RS04600 (C4N11_04600) - 860412..860792 (+) 381 WP_000157154.1 VOC family protein -

Sequence

Protein


Download         Length: 746 a.a.        Molecular weight: 84589.24 Da        Isoelectric Point: 9.8000

>NTDB_id=271428 C4N11_RS04565 WP_000942392.1 854462..856702(+) (comEC/celB) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGYLNTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLIGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRSLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKQFVVELQATQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGWNSWKIESVR

Nucleotide


Download         Length: 2241 bp        

>NTDB_id=271428 C4N11_RS04565 WP_000942392.1 854462..856702(+) (comEC/celB) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTACCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGATATCTGAACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAATTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTAGAGGGCATTATTCGCTTGGT
CTCGCAGGTGGCAAGGAGACCGCTTGTCTTTGGTCAACCCAACGCATGGCTTTTAATCTTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CACAGAGAAGCTTGATACCCTATCTTAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTGATTTTGACAAATACGGACAAG
GAACATGTCGGAGATTTGTTAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTTTGAAGCA
GAAGCAATTTGTGGTAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCCCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTACCGAACTGACCAGCAAGGAGCTATACGGTTTAAAGGTTGGAATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

Metallo-beta-lactamase superfamily (Lactamase_B)

(492-693)

Domain of unknown function (DUF4131) (DUF4131)

(30-177)

Competence protein (Competence)

(216-458)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6I3VL05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus pneumoniae TIGR4

97.721

100

0.977
  comEC/celB Streptococcus pneumoniae Rx1

96.649

100

0.966
  comEC/celB Streptococcus pneumoniae D39

96.649

100

0.966
  comEC/celB Streptococcus pneumoniae R6

96.649

100

0.966
  comEC/celB Streptococcus mitis SK321

92.493

100

0.925
  comEC/celB Streptococcus mitis NCTC 12261

92.349

99.866

0.922
  comEC Lactococcus lactis subsp. cremoris KW2

44.534

99.33

0.442

Multiple sequence alignment