Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SPD_RS02520 Genome accession   NC_008533
Coordinates   477293..478030 (+) Length   245 a.a.
NCBI ID   WP_001219139.1    Uniprot ID   Q9F2F6
Organism   Streptococcus pneumoniae D39     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 472293..483030
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPD_RS02490 (SPD_0462) - 473625..473912 (-) 288 WP_000777760.1 hypothetical protein -
  SPD_RS02495 (SPD_0463) - 473922..474332 (-) 411 WP_001278301.1 HIT family protein -
  SPD_RS02500 (SPD_0464) pptA 474400..475131 (+) 732 WP_000889919.1 ABC transporter ATP-binding protein Regulator
  SPD_RS02505 (SPD_0465) - 475128..476177 (+) 1050 WP_000653770.1 ABC transporter permease -
  SPD_RS02510 (SPD_0466) - 476345..476674 (-) 330 WP_000132569.1 hypothetical protein -
  SPD_RS02515 (SPD_0467) - 476950..477288 (+) 339 WP_000682124.1 LytTR family DNA-binding domain-containing protein -
  SPD_RS02520 (SPD_0468) comE/blpR 477293..478030 (+) 738 WP_001219139.1 response regulator transcription factor Regulator
  SPD_RS02525 (SPD_0469) - 478044..479384 (+) 1341 WP_001017622.1 sensor histidine kinase -
  SPD_RS02530 (SPD_0470) blpC 479426..479581 (-) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  SPD_RS02535 (SPD_0471) - 479638..480999 (-) 1362 Protein_471 bacteriocin secretion accessory protein -
  SPD_RS02540 (SPD_0472) comA/nlmT 481010..482686 (-) 1677 WP_306423909.1 peptide cleavage/export ABC transporter Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28814.94 Da        Isoelectric Point: 6.0454

>NTDB_id=26686 SPD_RS02520 WP_001219139.1 477293..478030(+) (comE/blpR) [Streptococcus pneumoniae D39]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=26686 SPD_RS02520 WP_001219139.1 477293..478030(+) (comE/blpR) [Streptococcus pneumoniae D39]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCTGAGTTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9F2F6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.882

96.735

0.424
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384

Multiple sequence alignment