Detailed information NTG0026562

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LACR_RS08195
• Genome accession: NC_008527
• Coordinates: 1609217..1609909 (-)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris subsp. cremoris SK11
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1604217..1614909

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LACR_RS08175 (LACR_1697)	murD	1604371..1605720 (-)	1350	WP_011676627.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
LACR_RS08180 (LACR_1698)	-	1605889..1606230 (-)	342	WP_011676628.1	P-II family nitrogen regulator	-
LACR_RS08185 (LACR_1699)	-	1606312..1607553 (-)	1242	WP_011676629.1	ammonium transporter	-
LACR_RS08190 (LACR_1700)	covS	1607739..1609211 (-)	1473	WP_021037558.1	HAMP domain-containing histidine kinase	Regulator
LACR_RS08195 (LACR_1701)	covR	1609217..1609909 (-)	693	WP_011676631.1	response regulator transcription factor	Regulator
LACR_RS08200 (LACR_1702)	-	1610066..1610596 (-)	531	WP_011676632.1	DUF177 domain-containing protein	-
LACR_RS08205 (LACR_1703)	-	1610729..1610974 (-)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LACR_RS08210 (LACR_1704)	-	1611298..1611660 (-)	363	WP_011676634.1	TIGR02328 family protein	-
LACR_RS08215 (LACR_1705)	-	1611897..1612808 (-)	912	WP_011676635.1	CHAP domain-containing protein	-
LACR_RS08220 (LACR_1706)	-	1612901..1613737 (-)	837	WP_011834858.1	metallophosphoesterase	-
LACR_RS08225 (LACR_1707)	arsC	1613849..1614253 (-)	405	WP_011676637.1	arsenate reductase (thioredoxin)	-
LACR_RS13685	-	1614445..1614582 (+)	138	Protein_1600	Ltp family lipoprotein	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=26562 LACR_RS08195 WP_011676631.1 1609217..1609909(-) (covR) [Lactococcus cremoris subsp. cremoris SK11]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=26562 LACR_RS08195 WP_011676631.1 1609217..1609909(-) (covR) [Lactococcus cremoris subsp. cremoris SK11]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361