Detailed information
Bioinformatically predicted
Overview
| Name | htrA | Type | Regulator |
| Locus tag | C0649_RS01240 | Genome accession | NZ_CP025685 |
| Coordinates | 244538..245827 (-) | Length | 429 a.a. |
| NCBI ID | WP_002290101.1 | Uniprot ID | A0A828ZUK2 |
| Organism | Enterococcus faecium strain CBA7134 | ||
| Function | repress competence development (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 212989..277067 | 244538..245827 | within | 0 |
Gene organization within MGE regions
Location: 212989..277067
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C0649_RS01070 (C0649_01075) | rhaM | 213246..213557 (+) | 312 | Protein_208 | L-rhamnose mutarotase | - |
| C0649_RS01075 (C0649_01080) | fucO | 213639..214789 (+) | 1151 | Protein_209 | lactaldehyde reductase | - |
| C0649_RS01080 (C0649_01085) | - | 214916..215674 (+) | 759 | WP_128251677.1 | IclR family transcriptional regulator | - |
| C0649_RS01085 (C0649_01090) | - | 215774..216418 (+) | 645 | WP_002288242.1 | bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase | - |
| C0649_RS01090 (C0649_01095) | - | 216425..217432 (+) | 1008 | WP_070544356.1 | sugar kinase | - |
| C0649_RS01095 (C0649_01100) | kduI | 217448..218290 (+) | 843 | WP_002288239.1 | 5-dehydro-4-deoxy-D-glucuronate isomerase | - |
| C0649_RS01100 (C0649_01105) | - | 218310..219113 (+) | 804 | WP_002320630.1 | gluconate 5-dehydrogenase | - |
| C0649_RS01105 (C0649_01110) | fni | 219231..220286 (-) | 1056 | WP_002293369.1 | type 2 isopentenyl-diphosphate Delta-isomerase | - |
| C0649_RS01110 (C0649_01115) | - | 220283..221368 (-) | 1086 | WP_002293368.1 | phosphomevalonate kinase | - |
| C0649_RS01115 (C0649_01120) | mvaD | 221381..222358 (-) | 978 | WP_002293367.1 | diphosphomevalonate decarboxylase | - |
| C0649_RS01120 (C0649_01125) | mvk | 222351..223295 (-) | 945 | WP_002293366.1 | mevalonate kinase | - |
| C0649_RS01125 (C0649_01130) | - | 223612..224271 (+) | 660 | WP_002293362.1 | deoxynucleoside kinase | - |
| C0649_RS01130 (C0649_01135) | - | 224355..225260 (+) | 906 | WP_002313988.1 | magnesium transporter CorA family protein | - |
| C0649_RS01135 (C0649_01140) | - | 225262..225894 (-) | 633 | WP_002336138.1 | pentapeptide repeat-containing protein | - |
| C0649_RS01140 (C0649_01145) | infC | 226214..226738 (+) | 525 | WP_002293357.1 | translation initiation factor IF-3 | - |
| C0649_RS01145 (C0649_01150) | rpmI | 226810..227010 (+) | 201 | WP_002289309.1 | 50S ribosomal protein L35 | - |
| C0649_RS01150 (C0649_01155) | rplT | 227063..227422 (+) | 360 | WP_002293355.1 | 50S ribosomal protein L20 | - |
| C0649_RS01155 (C0649_01160) | - | 227661..229481 (+) | 1821 | Protein_225 | DUF6056 family protein | - |
| C0649_RS01160 (C0649_01165) | - | 229631..231057 (-) | 1427 | Protein_226 | IS3 family transposase | - |
| C0649_RS01165 (C0649_01170) | - | 231326..232663 (+) | 1338 | WP_128251679.1 | citrate transporter | - |
| C0649_RS01170 (C0649_01175) | - | 232711..234840 (+) | 2130 | WP_002336134.1 | hydantoinase/oxoprolinase family protein | - |
| C0649_RS01175 (C0649_01180) | - | 234815..235504 (+) | 690 | WP_002336133.1 | hypothetical protein | - |
| C0649_RS01185 (C0649_01190) | - | 235898..236584 (-) | 687 | WP_002312480.1 | GntR family transcriptional regulator | - |
| C0649_RS14525 | - | 236719..236886 (-) | 168 | WP_002292624.1 | hypothetical protein | - |
| C0649_RS01190 (C0649_01195) | - | 236963..237403 (-) | 441 | WP_002336132.1 | acyl-CoA thioesterase | - |
| C0649_RS01195 (C0649_01200) | - | 237407..238252 (-) | 846 | WP_002336131.1 | NAD(P)H-hydrate dehydratase | - |
| C0649_RS01200 (C0649_01205) | pepV | 238401..239819 (+) | 1419 | WP_002294157.1 | dipeptidase PepV | - |
| C0649_RS01205 (C0649_01210) | - | 239875..240822 (-) | 948 | WP_002315618.1 | glycosyltransferase family 2 protein | - |
| C0649_RS01210 (C0649_01215) | - | 241044..241394 (-) | 351 | WP_002292629.1 | PepSY domain-containing protein | - |
| C0649_RS01215 (C0649_01220) | pepA | 241594..242673 (+) | 1080 | WP_002336130.1 | glutamyl aminopeptidase | - |
| C0649_RS01220 (C0649_01225) | - | 242816..243136 (+) | 321 | WP_002292632.1 | thioredoxin family protein | - |
| C0649_RS01225 (C0649_01230) | - | 243158..243622 (+) | 465 | WP_002336129.1 | universal stress protein | - |
| C0649_RS01235 (C0649_01240) | ytpR | 243827..244432 (+) | 606 | WP_002336128.1 | YtpR family tRNA-binding protein | - |
| C0649_RS01240 (C0649_01245) | htrA | 244538..245827 (-) | 1290 | WP_002290101.1 | trypsin-like peptidase domain-containing protein | Regulator |
| C0649_RS01245 (C0649_01250) | rlmH | 246255..246734 (+) | 480 | WP_002336127.1 | 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH | - |
| C0649_RS01250 (C0649_01255) | - | 247045..247719 (+) | 675 | WP_088745835.1 | hypothetical protein | - |
| C0649_RS01255 (C0649_01260) | - | 248280..249188 (+) | 909 | WP_128251680.1 | IS982-like element ISEfm1 family transposase | - |
| C0649_RS01260 (C0649_01265) | - | 249275..250129 (+) | 855 | WP_002317112.1 | AraC family transcriptional regulator | - |
| C0649_RS01265 (C0649_01270) | - | 250226..252475 (+) | 2250 | WP_002322792.1 | alpha-galactosidase | - |
| C0649_RS01270 (C0649_01275) | - | 252478..253650 (+) | 1173 | WP_002317114.1 | MFS transporter | - |
| C0649_RS01275 (C0649_01280) | - | 253869..255046 (+) | 1178 | Protein_248 | IS256-like element ISEf1 family transposase | - |
| C0649_RS01280 (C0649_01285) | - | 255235..255543 (+) | 309 | WP_002334080.1 | DUF960 domain-containing protein | - |
| C0649_RS01285 (C0649_01290) | - | 255570..255869 (+) | 300 | WP_025478468.1 | hypothetical protein | - |
| C0649_RS01290 (C0649_01295) | - | 256043..256594 (+) | 552 | WP_002296259.1 | DUF1643 domain-containing protein | - |
| C0649_RS01295 (C0649_01300) | - | 256741..257034 (+) | 294 | WP_128251681.1 | Mor transcription activator family protein | - |
| C0649_RS01300 (C0649_01305) | - | 257027..257323 (+) | 297 | WP_002326408.1 | hypothetical protein | - |
| C0649_RS01305 (C0649_01310) | - | 257398..258396 (+) | 999 | WP_128251682.1 | DUF4767 domain-containing protein | - |
| C0649_RS14780 | - | 258731..259357 (-) | 627 | WP_241566789.1 | hypothetical protein | - |
| C0649_RS14785 | - | 259424..259960 (-) | 537 | WP_241566790.1 | hypothetical protein | - |
| C0649_RS01315 (C0649_01320) | - | 260068..260901 (+) | 834 | WP_002389975.1 | replication initiation factor domain-containing protein | - |
| C0649_RS14530 | - | 260945..261109 (+) | 165 | WP_002340116.1 | hypothetical protein | - |
| C0649_RS01320 (C0649_01325) | - | 261084..261350 (+) | 267 | WP_002286113.1 | adenylate kinase | - |
| C0649_RS01325 (C0649_01330) | - | 261616..262989 (+) | 1374 | WP_128251683.1 | recombinase family protein | - |
| C0649_RS01330 (C0649_01335) | - | 262993..264630 (+) | 1638 | WP_128251684.1 | recombinase family protein | - |
| C0649_RS01335 (C0649_01340) | - | 264894..265154 (+) | 261 | WP_025479356.1 | hypothetical protein | - |
| C0649_RS01340 (C0649_01345) | - | 265237..267021 (+) | 1785 | WP_128251685.1 | class I SAM-dependent DNA methyltransferase | - |
| C0649_RS01345 (C0649_01350) | - | 267011..268264 (+) | 1254 | WP_128251686.1 | restriction endonuclease subunit S | - |
| C0649_RS01350 (C0649_01355) | - | 268277..271309 (+) | 3033 | WP_164874290.1 | type I restriction endonuclease | - |
| C0649_RS01355 (C0649_01360) | - | 271499..272083 (+) | 585 | WP_128251688.1 | DUF262 domain-containing protein | - |
| C0649_RS01360 (C0649_01365) | - | 272080..273219 (+) | 1140 | WP_073490907.1 | IS256 family transposase | - |
| C0649_RS01365 (C0649_01370) | - | 273597..275639 (+) | 2043 | WP_128251689.1 | PTS sugar transporter subunit IIA | - |
| C0649_RS01370 (C0649_01375) | - | 275650..276270 (+) | 621 | WP_002331202.1 | bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase | - |
| C0649_RS01375 (C0649_01380) | - | 276282..276740 (+) | 459 | WP_002326530.1 | PTS sugar transporter subunit IIA | - |
| C0649_RS01380 (C0649_01385) | - | 276759..277037 (+) | 279 | WP_002331203.1 | PTS sugar transporter subunit IIB | - |
Sequence
Protein
Download Length: 429 a.a. Molecular weight: 44916.93 Da Isoelectric Point: 4.5419
>NTDB_id=263266 C0649_RS01240 WP_002290101.1 244538..245827(-) (htrA) [Enterococcus faecium strain CBA7134]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVMMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVMMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN
Nucleotide
Download Length: 1290 bp
>NTDB_id=263266 C0649_RS01240 WP_002290101.1 244538..245827(-) (htrA) [Enterococcus faecium strain CBA7134]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAAAATTCAGCCGGTGAAACAGTTGTCGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAATCAATCAAGCGGTTTTGGCGGATTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGACAGCAAGGTTTGGAAGTCATGATGAAAGAC
GGGACGAAAGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGATAAAGT
CGAAACGGTTGCCTCTTTTGGTGACTCAAGCGCTCTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGAT
CTGAATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCTTTGAATCGACAAGTAACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCGATCAACCCGGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCGACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATATGATGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGCGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAAAATTCAGCCGGTGAAACAGTTGTCGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAATCAATCAAGCGGTTTTGGCGGATTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGACAGCAAGGTTTGGAAGTCATGATGAAAGAC
GGGACGAAAGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGATAAAGT
CGAAACGGTTGCCTCTTTTGGTGACTCAAGCGCTCTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGAT
CTGAATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCTTTGAATCGACAAGTAACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCGATCAACCCGGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCGACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATATGATGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGCGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| htrA | Streptococcus gordonii str. Challis substr. CH1 |
54.569 |
91.841 |
0.501 |
| htrA | Streptococcus mutans UA159 |
60.169 |
82.517 |
0.496 |
| htrA | Streptococcus mitis NCTC 12261 |
52.778 |
92.308 |
0.487 |
| htrA | Streptococcus pneumoniae TIGR4 |
59.05 |
78.555 |
0.464 |
| htrA | Streptococcus pneumoniae Rx1 |
59.05 |
78.555 |
0.464 |
| htrA | Streptococcus pneumoniae D39 |
59.05 |
78.555 |
0.464 |
| htrA | Streptococcus pneumoniae R6 |
59.05 |
78.555 |
0.464 |