Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   CXP32_RS06745 Genome accession   NZ_CP025256
Coordinates   1284537..1285274 (-) Length   245 a.a.
NCBI ID   WP_000782668.1    Uniprot ID   Q97Q68
Organism   Streptococcus pneumoniae strain Xen35     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1279537..1290274
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CXP32_RS06725 (CXP32_06725) msrB 1280996..1281934 (-) 939 WP_000818207.1 peptide-methionine (R)-S-oxide reductase MsrB -
  CXP32_RS12365 (CXP32_06730) - 1282001..1282153 (-) 153 WP_239424733.1 chlorohydrolase -
  CXP32_RS06735 (CXP32_06735) thrB 1282229..1283098 (-) 870 WP_000692438.1 homoserine kinase -
  CXP32_RS06740 (CXP32_06740) - 1283100..1284386 (-) 1287 WP_000216382.1 homoserine dehydrogenase -
  CXP32_RS06745 (CXP32_06745) mecA 1284537..1285274 (-) 738 WP_000782668.1 adaptor protein MecA Regulator
  CXP32_RS06750 (CXP32_06750) - 1285474..1286508 (-) 1035 WP_000461505.1 hypothetical protein -
  CXP32_RS06755 (CXP32_06755) - 1286537..1287970 (-) 1434 WP_000565078.1 O-antigen polysaccharide polymerase Wzy family protein -
  CXP32_RS06760 (CXP32_06760) - 1287986..1288972 (-) 987 WP_000446975.1 glycosyltransferase family 2 protein -
  CXP32_RS06765 (CXP32_06765) - 1288974..1290077 (-) 1104 WP_000225907.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28391.20 Da        Isoelectric Point: 4.0199

>NTDB_id=259464 CXP32_RS06745 WP_000782668.1 1284537..1285274(-) (mecA) [Streptococcus pneumoniae strain Xen35]
MKMKQISDTTLKITISLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEVKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=259464 CXP32_RS06745 WP_000782668.1 1284537..1285274(-) (mecA) [Streptococcus pneumoniae strain Xen35]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATATCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGTCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q97Q68

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae TIGR4

100

100

1
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus thermophilus LMD-9

48.594

100

0.494
  mecA Streptococcus thermophilus LMG 18311

48.193

100

0.49
  mecA Streptococcus mutans UA159

48.571

100

0.486

Multiple sequence alignment