Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   CWI26_RS01295 Genome accession   NZ_CP025043
Coordinates   244260..245000 (+) Length   246 a.a.
NCBI ID   WP_024376264.1    Uniprot ID   A0A2I5KS06
Organism   Streptococcus suis strain AH681     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 239260..250000
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CWI26_RS01270 (CWI26_01270) - 240127..242460 (+) 2334 WP_024378072.1 endonuclease MutS2 -
  CWI26_RS12135 - 242493..242891 (-) 399 WP_024378071.1 hypothetical protein -
  CWI26_RS01280 (CWI26_01280) - 243115..243342 (+) 228 WP_024378070.1 hypothetical protein -
  CWI26_RS01285 (CWI26_01285) - 243323..243628 (+) 306 WP_044672279.1 hypothetical protein -
  CWI26_RS01290 (CWI26_01290) - 243919..244260 (+) 342 WP_024378069.1 LytTR family DNA-binding domain-containing protein -
  CWI26_RS01295 (CWI26_01295) comE/blpR 244260..245000 (+) 741 WP_024376264.1 response regulator transcription factor Regulator
  CWI26_RS01300 (CWI26_01300) - 245010..246341 (+) 1332 WP_100881080.1 GHKL domain-containing protein -
  CWI26_RS01305 (CWI26_01305) - 246538..246687 (-) 150 WP_100881081.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  CWI26_RS01310 (CWI26_01310) - 246784..248145 (-) 1362 WP_100881082.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 28757.89 Da        Isoelectric Point: 7.0265

>NTDB_id=257598 CWI26_RS01295 WP_024376264.1 244260..245000(+) (comE/blpR) [Streptococcus suis strain AH681]
MNVFVLEDDFAQQSRIESIVGSLMERHHIQTKKFEVFGKPDQLIRAVEEKGAHQLFFLDIEIRADDKKGLEVAQQIRDID
PFAIIVFVTTHSEYMPLAFRYQVSALDFIDKELAPAEFEARIETALLYANGKNSRTVAEDSFYYKSRYAQVQVPFADILY
IETSPHPHRVILHTEKDRLEFTGNLADILKQEKRLLQCHRSYLVNPNNVVKVDRQMKVLYFRNGSNCYVARNRMELVHNA
IRDLHR

Nucleotide


Download         Length: 741 bp        

>NTDB_id=257598 CWI26_RS01295 WP_024376264.1 244260..245000(+) (comE/blpR) [Streptococcus suis strain AH681]
ATGAATGTATTTGTTTTAGAAGATGATTTTGCCCAACAGTCACGGATTGAGTCAATCGTTGGTAGTTTAATGGAGCGACA
CCACATTCAGACTAAGAAGTTTGAAGTTTTTGGGAAACCAGACCAGTTGATTCGGGCAGTAGAGGAAAAAGGAGCTCATC
AACTCTTTTTCTTGGACATTGAGATTCGAGCAGATGACAAGAAGGGGTTAGAGGTGGCTCAACAGATTCGTGATATTGAT
CCCTTTGCCATTATCGTTTTTGTTACCACTCACTCCGAGTATATGCCTCTGGCCTTTCGTTATCAGGTATCGGCTCTGGA
TTTTATTGATAAGGAGCTAGCCCCGGCCGAGTTTGAGGCACGGATTGAGACAGCTCTCCTTTATGCTAATGGGAAAAATA
GTCGGACGGTGGCAGAGGATTCCTTCTATTACAAGTCGCGTTATGCCCAGGTCCAAGTTCCCTTTGCGGATATTCTCTAT
ATCGAAACCTCTCCTCATCCCCATCGGGTTATTCTGCATACGGAGAAGGATCGCTTAGAGTTTACAGGGAATTTGGCAGA
TATTTTGAAACAAGAAAAAAGACTGCTCCAGTGTCATCGCTCTTACTTGGTCAATCCCAATAATGTGGTCAAGGTTGATC
GACAGATGAAAGTTCTCTACTTCCGAAATGGTAGCAACTGCTATGTCGCTCGGAATCGAATGGAGCTAGTTCATAATGCC
ATTCGAGACTTGCATAGATAG

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-240)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2I5KS06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.209

100

0.528
  comE/comE1 Streptococcus equinus JB1

44.215

98.374

0.435
  comE/comE2 Streptococcus equinus JB1

37.705

99.187

0.374
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.398

100

0.374
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.398

100

0.374

Multiple sequence alignment