Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   CTW00_RS04995 Genome accession   NZ_CP024843
Coordinates   1011347..1012108 (+) Length   253 a.a.
NCBI ID   WP_003100848.1    Uniprot ID   A0A3L8GPI6
Organism   Streptococcus iniae strain FP5228     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1006347..1017108
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CTW00_RS04975 (CTW00_01005) - 1007290..1007406 (-) 117 WP_016355825.1 putative metal homeostasis protein -
  CTW00_RS04980 (CTW00_01006) - 1007604..1008344 (-) 741 WP_003100842.1 amino acid ABC transporter ATP-binding protein -
  CTW00_RS04985 (CTW00_01007) - 1008337..1009905 (-) 1569 WP_003100845.1 ABC transporter substrate-binding protein/permease -
  CTW00_RS04990 (CTW00_01008) - 1010388..1011227 (+) 840 WP_003100846.1 undecaprenyl-diphosphate phosphatase -
  CTW00_RS04995 (CTW00_01009) mecA 1011347..1012108 (+) 762 WP_003100848.1 adaptor protein MecA Regulator
  CTW00_RS05000 (CTW00_01010) - 1012111..1013271 (+) 1161 WP_016355826.1 MraY family glycosyltransferase -
  CTW00_RS05005 (CTW00_01011) sufC 1013395..1014165 (+) 771 WP_003100850.1 Fe-S cluster assembly ATPase SufC -
  CTW00_RS05010 (CTW00_01012) sufD 1014236..1015498 (+) 1263 WP_003100851.1 Fe-S cluster assembly protein SufD -
  CTW00_RS05015 (CTW00_01013) - 1015517..1016743 (+) 1227 WP_003100852.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29300.80 Da        Isoelectric Point: 4.0647

>NTDB_id=255817 CTW00_RS04995 WP_003100848.1 1011347..1012108(+) (mecA) [Streptococcus iniae strain FP5228]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYAVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSDI
NKDLNFEDLSDLGDISQMSPEDFFKSIEKAMMEKGDVNAHEKLEKIEEMMEEAINTSQENAEPTQTQVESEPQVLDYVHY
VLDFDNITEAVTFAKTLDFSIEASELYKDGGRYHMTILLDVQNQPSYYANIMYARLIEHASAGTRTRAYLQEHASQLIDD
NAIEQLQRIELVD

Nucleotide


Download         Length: 762 bp        

>NTDB_id=255817 CTW00_RS04995 WP_003100848.1 1011347..1012108(+) (mecA) [Streptococcus iniae strain FP5228]
ATGGAGATGAAACAGATTAGCGAAACGACGCTAAAAATAACAATCAGCATGGATGATTTAGAAGAAAGAGGAATGGAGCT
TAAAGATTTTTTAATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATGCGGTTATGGATGAGTTAGATTTACCAGATAATT
TTAAAGATAGTGGTATGTTAAGTTTTCGAGTGACACCACGTAAAGACAGACTAGATGTGTTTGTTACTAAATCTGATATT
AATAAAGACCTTAACTTTGAAGACTTATCTGATTTGGGTGATATTTCCCAAATGAGTCCAGAAGATTTCTTCAAAAGCAT
TGAAAAAGCAATGATGGAAAAGGGCGATGTTAATGCACATGAAAAACTTGAAAAAATCGAAGAAATGATGGAGGAAGCTA
TCAATACCAGTCAAGAAAATGCTGAGCCTACTCAGACACAGGTTGAAAGCGAACCGCAAGTTTTAGATTATGTGCATTAT
GTTTTAGACTTTGACAACATAACAGAGGCAGTGACTTTTGCCAAAACTCTTGATTTTTCGATTGAAGCTTCGGAATTGTA
TAAAGATGGTGGCCGCTACCATATGACTATTTTATTGGATGTTCAAAATCAACCGTCTTATTATGCCAACATTATGTATG
CTCGTCTTATTGAACATGCTAGTGCAGGTACACGTACAAGAGCTTATTTGCAGGAGCATGCGAGTCAATTAATTGATGAT
AATGCTATCGAACAACTACAAAGAATTGAATTGGTAGATTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-246)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3L8GPI6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

65.462

98.419

0.644
  mecA Streptococcus thermophilus LMD-9

60.887

98.024

0.597
  mecA Streptococcus thermophilus LMG 18311

60.081

98.024

0.589
  mecA Streptococcus pneumoniae Rx1

47.619

99.605

0.474
  mecA Streptococcus pneumoniae D39

47.619

99.605

0.474
  mecA Streptococcus pneumoniae R6

47.619

99.605

0.474
  mecA Streptococcus pneumoniae TIGR4

47.619

99.605

0.474

Multiple sequence alignment