Detailed information NTG0248477

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: CPS94_RS08575
• Genome accession: NZ_CP023565
• Coordinates: 1730174..1732330 (-)
• Length: 718 a.a.
• NCBI ID: WP_112193743.1
• Uniprot ID: A0AAD0L138
• Organism: Ligilactobacillus murinus strain CR147
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1725174..1737330

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CPS94_RS08545 (CPS94_08540)	-	1725862..1726173 (-)	312	WP_112193730.1	hypothetical protein	-
CPS94_RS08550 (CPS94_08545)	-	1726185..1726412 (-)	228	WP_112193732.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
CPS94_RS08555 (CPS94_08550)	-	1726556..1727332 (-)	777	WP_112193734.1	LytTR family DNA-binding domain-containing protein	-
CPS94_RS08560 (CPS94_08555)	-	1727338..1728057 (-)	720	WP_112193736.1	GHKL domain-containing protein	-
CPS94_RS08565 (CPS94_08560)	-	1728058..1728600 (-)	543	WP_112193738.1	hypothetical protein	-
CPS94_RS08570 (CPS94_08565)	-	1728794..1730161 (-)	1368	WP_112193740.1	bacteriocin secretion accessory protein	-
CPS94_RS08575 (CPS94_08570)	comA	1730174..1732330 (-)	2157	WP_112193743.1	peptide cleavage/export ABC transporter	Regulator
CPS94_RS08580 (CPS94_08575)	-	1732464..1732694 (-)	231	WP_112193745.1	hypothetical protein	-
CPS94_RS08585 (CPS94_08580)	-	1732951..1733769 (-)	819	WP_162626425.1	LytTR family transcriptional regulator DNA-binding domain-containing protein	-
CPS94_RS08590 (CPS94_08585)	-	1733916..1734650 (-)	735	WP_162626426.1	LytTR family DNA-binding domain-containing protein	-
CPS94_RS08595 (CPS94_08590)	-	1734730..1734909 (-)	180	WP_162626427.1	hypothetical protein	-
CPS94_RS08600 (CPS94_08595)	-	1734957..1735265 (-)	309	WP_112193753.1	hypothetical protein	-
CPS94_RS08605 (CPS94_08600)	-	1735323..1735613 (-)	291	WP_112193755.1	hypothetical protein	-
CPS94_RS08610 (CPS94_08605)	-	1735692..1736204 (-)	513	WP_112193757.1	hypothetical protein	-
CPS94_RS08615 (CPS94_08610)	-	1736206..1736934 (-)	729	Protein_1675	ABC transporter ATP-binding protein	-
CPS94_RS08620 (CPS94_08615)	-	1737089..1737295 (-)	207	WP_112193759.1	Blp family class II bacteriocin	-

Sequence

Protein

• Length: 718 a.a.
• Molecular weight: 80812.45 Da
• Isoelectric Point: 8.0223

>NTDB_id=248477 CPS94_RS08575 WP_112193743.1 1730174..1732330(-) (comA) [Ligilactobacillus murinus strain CR147]
MRKFYRYYTSQLDEMDCGVACLAMILKQYGSRVSLAYLRNLAKTDLEGTTALGLVRAAQALNFDTQAIQADMSLFEVSNL
KYPFIVHVVKNETLLHYYVVLGANKKNILLADPAPNVGVIKMSRQRFEKEWSGIALLFASNIDYSPVKEERQGLWMLFVK
LKRQWQLIINIVLAAMLITLISILGSYFLQAVIDNYIPNSLNNTLAIVASGLLILYVFNSMFNYARDFLLTILGQRLSIE
IILGYIKHIFELPMEFFATRKTGEIVSRFNDASKIIDALASTVISMFLDVGIVVIMGSVLAIQNRTLFLITLGCLPLYLL
VVVAFTKSFEKLNNKQMESNAVLSSSIIEDIQGIETIKALNSEHERYQKIDGQFVDFLRKSLDYTKIDILQQALKTFVHL
ALNVIILWIGAQLVMKNEISLGQLMAYNALLAYFTDPLQNIINLQPKLQSAQVANNRLNEVFLVKGEFNAKKHKLLADQL
AGVITFKDVSYCYGYGQNVLEGINLTIKEHEKLTIVGMSGSGKSTLVKLLVNFFEPTIGSITFNEHQIKNIDKHLLRSYI
NYVPQTPYVFSGTIMENLTLGNRSDVTEKDIFKACQLAMITEDIEKMPLQYDTVLDENGGILSGGQKQRITIARAILSPA
KVLIFDESTSGLDAITEKKLIDNLMSLEDRTIIFIAHRLAIAKRTDNILVLDKGRIVEQGDHETLMNKNGYYASLVNS

Nucleotide

• Length: 2157 bp

>NTDB_id=248477 CPS94_RS08575 WP_112193743.1 1730174..1732330(-) (comA) [Ligilactobacillus murinus strain CR147]
ATGCGTAAATTCTATAGATACTACACATCACAACTAGATGAAATGGATTGTGGGGTAGCCTGTTTAGCCATGATATTAAA
ACAATATGGATCAAGAGTTTCACTAGCTTATTTACGTAATCTTGCTAAAACAGATCTAGAAGGAACTACAGCGTTGGGGT
TAGTAAGAGCGGCTCAAGCTCTAAATTTTGACACGCAAGCAATACAGGCAGATATGTCGTTGTTTGAAGTTTCAAATTTA
AAATATCCATTTATCGTACATGTGGTTAAAAATGAAACTTTATTACATTACTATGTGGTTTTAGGCGCAAACAAAAAGAA
TATTTTATTAGCAGATCCAGCTCCAAATGTTGGAGTTATCAAAATGTCGCGACAACGTTTTGAAAAAGAATGGAGTGGGA
TCGCATTGTTATTTGCCTCAAATATTGATTATTCTCCAGTTAAAGAAGAGCGACAAGGCTTATGGATGTTATTTGTAAAG
TTAAAAAGGCAATGGCAGTTAATTATAAATATAGTATTAGCTGCTATGCTGATTACTTTGATCAGCATTTTAGGATCATA
CTTTTTGCAGGCTGTGATCGATAACTACATTCCAAATAGCTTAAATAATACATTGGCTATTGTTGCTAGTGGGTTACTGA
TTTTATATGTATTTAATTCTATGTTCAATTATGCACGAGATTTTTTATTGACGATTTTAGGACAAAGATTATCAATTGAA
ATTATTTTGGGATATATCAAACATATTTTTGAATTACCAATGGAATTTTTTGCAACAAGAAAAACTGGGGAGATAGTTTC
ACGTTTTAATGATGCTAGTAAAATAATTGATGCTTTAGCTAGCACTGTAATTTCGATGTTTTTAGATGTCGGCATAGTTG
TGATCATGGGAAGTGTTTTAGCAATACAGAATAGGACACTTTTTTTGATAACCTTGGGTTGCTTACCTTTATATTTGTTG
GTAGTTGTAGCTTTTACAAAAAGTTTTGAAAAATTAAATAATAAGCAAATGGAAAGTAATGCTGTCTTGAGTTCATCAAT
TATTGAAGATATTCAAGGTATAGAGACAATCAAAGCATTGAATAGTGAACATGAACGCTACCAAAAAATCGATGGACAAT
TCGTAGATTTTTTGCGTAAAAGTTTAGACTATACAAAAATAGATATTTTACAGCAAGCTTTGAAAACATTTGTACATTTG
GCCTTAAATGTGATTATTTTGTGGATCGGTGCACAATTGGTTATGAAAAATGAGATATCATTAGGGCAATTGATGGCCTA
CAATGCGTTATTGGCATATTTTACTGATCCGCTACAAAATATTATCAACTTACAACCTAAATTACAAAGCGCACAGGTAG
CAAATAATCGTTTAAATGAAGTTTTTTTGGTAAAAGGTGAGTTTAACGCTAAGAAACATAAGTTATTAGCAGATCAGCTA
GCTGGTGTGATCACTTTTAAAGATGTATCTTATTGCTATGGTTATGGACAAAACGTTTTAGAAGGAATAAATTTGACGAT
CAAAGAACATGAAAAATTGACGATCGTAGGGATGAGCGGATCAGGGAAATCGACTTTAGTTAAGTTACTAGTTAATTTTT
TTGAACCAACGATAGGGAGTATAACTTTTAATGAACATCAGATAAAAAATATTGATAAACATCTTTTAAGAAGTTATATC
AATTATGTTCCACAAACACCATATGTATTTTCAGGAACTATCATGGAAAACTTAACTTTGGGGAATCGTTCAGACGTTAC
TGAAAAAGATATATTTAAAGCGTGTCAATTAGCAATGATCACAGAAGACATAGAGAAGATGCCGTTACAATATGACACTG
TACTTGATGAGAATGGTGGAATCTTATCTGGGGGTCAGAAACAACGTATTACGATTGCACGGGCAATACTGTCTCCAGCA
AAAGTTTTGATTTTTGATGAATCAACAAGTGGCTTGGATGCAATAACTGAGAAAAAATTGATCGATAATTTGATGTCACT
TGAAGATAGGACCATTATTTTTATTGCACATCGACTGGCAATAGCTAAGCGGACCGATAATATTTTAGTGTTAGATAAAG
GCAGGATAGTTGAACAAGGTGATCATGAAACATTAATGAATAAAAATGGATACTATGCTAGTTTAGTCAATAGTTAG

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (169-438)

• Peptidase C39 family (Peptidase_C39) (7-141)

• ABC transporter (ABC_tran) (500-650)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	57.083	99.304	0.567
comA	Streptococcus pneumoniae Rx1	56.662	99.304	0.563
comA	Streptococcus pneumoniae D39	56.662	99.304	0.563
comA	Streptococcus pneumoniae R6	56.662	99.304	0.563
comA	Streptococcus pneumoniae TIGR4	56.662	99.304	0.563
comA	Streptococcus mitis SK321	56.522	99.304	0.561
comA	Streptococcus gordonii str. Challis substr. CH1	56.084	99.582	0.558
comA/nlmT	Streptococcus mutans UA159	52.235	99.721	0.521