Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   CO204_RS08005 Genome accession   NZ_CP023477
Coordinates   1577003..1578853 (-) Length   616 a.a.
NCBI ID   WP_106006812.1    Uniprot ID   -
Organism   Streptococcus mutans strain LAR01     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1572003..1583853
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CO204_RS07980 (CO204_07945) - 1572403..1572789 (-) 387 WP_002268943.1 S1 RNA-binding domain-containing protein -
  CO204_RS07985 (CO204_07950) - 1572773..1574188 (-) 1416 WP_002268942.1 Cof-type HAD-IIB family hydrolase -
  CO204_RS07990 (CO204_07955) - 1574232..1574873 (-) 642 WP_002263036.1 response regulator transcription factor -
  CO204_RS07995 (CO204_07960) - 1574866..1575870 (-) 1005 WP_106006811.1 sensor histidine kinase -
  CO204_RS08000 (CO204_07965) liaF 1575867..1576562 (-) 696 WP_002263038.1 cell wall-active antibiotics response protein LiaF -
  CO204_RS08005 (CO204_07970) pknB 1577003..1578853 (-) 1851 WP_106006812.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  CO204_RS08010 (CO204_07975) - 1578850..1579593 (-) 744 WP_002263040.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  CO204_RS08015 (CO204_07980) rsmB 1579632..1580954 (-) 1323 WP_173677996.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  CO204_RS08020 (CO204_07985) fmt 1580935..1581870 (-) 936 WP_002263042.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 616 a.a.        Molecular weight: 66913.71 Da        Isoelectric Point: 9.5258

>NTDB_id=247438 CO204_RS08005 WP_106006812.1 1577003..1578853(-) (pknB) [Streptococcus mutans strain LAR01]
MIQIGKLFAGRYRILQSIGRGGMADVYLANDLILDNEEVAIKVLRTNYQTDQVAVTRFQREARAMAELNHPNIVAIRDIG
EEDGQQFLAMEYVDGADLKKYIQDHAPLSNAEVIRIMKEVLSAMTLAHKKGIIHRDLKPQNVLLTKDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIAENKNVP
QALENVVIKATAKRLTDRYHSTQEMLQDLRTSLQPNRSRERKLVFSDASDTKPLPKLEQAAANSLAAQSLKNKTSNQDKV
DHKSKPKTKPQPKPKKKRHFLARFFKIFFILVAIGIAVLTYLVLTKPSTVSVPDVSGDKLSTAKMIIRKSGLKVGDVQKI
EDDNVGAGKVVRTNPSAGSKKREGSSVDIFVASAKGFKMEDYTGQDYKDAIDNLTNNYGVSRDSIVLKEVSSDDYSGGTV
IGQSPKPGKTYHPSSDKKITLKVVKVTMPNLKNSTYEEAVSTLTAMGISSSRIKAYDASDYSSEISSPSSSSLVVGQSPY
YGNTVSLSSNDDIILYVSTSGGSHSGSSSSESSNSEGTTSSEASTDSSSSATTTSH

Nucleotide


Download         Length: 1851 bp        

>NTDB_id=247438 CO204_RS08005 WP_106006812.1 1577003..1578853(-) (pknB) [Streptococcus mutans strain LAR01]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATTCTCCAGTCTATCGGACGAGGTGGGATGGCGGATGTTTA
TTTAGCTAATGATTTGATTTTAGATAATGAGGAAGTGGCCATTAAGGTTCTACGTACGAATTATCAGACAGATCAGGTTG
CTGTGACACGTTTTCAGCGGGAAGCACGTGCCATGGCAGAACTTAATCATCCTAATATTGTAGCCATTCGTGACATTGGA
GAAGAAGACGGTCAGCAATTCCTTGCAATGGAATATGTTGATGGCGCCGACTTGAAGAAATACATTCAAGATCACGCTCC
TTTATCAAATGCTGAAGTCATTAGAATCATGAAAGAGGTTCTTTCTGCTATGACTCTTGCCCACAAAAAGGGCATTATTC
ATCGGGATTTAAAACCTCAAAATGTTTTACTGACCAAAGATGGAACGGCTAAAGTAACAGACTTTGGTATTGCTGTGGCT
TTTGCTGAAACGAGTTTGACCCAAACCAATTCAATGCTGGGTTCAGTACATTACTTATCTCCTGAACAGGCGCGTGGTTC
TAAGGCTACTGTTCAAAGTGATATCTATGCAATGGGAATTATGCTTTTTGAAATGCTGACGGGGCATATTCCCTATGATG
GCGATAGTGCTGTTACAATTGCTTTGCAGCATTTTCAAAAGCCTTTACCATCTATTATTGCTGAGAATAAAAATGTCCCT
CAAGCTCTTGAAAATGTTGTTATTAAAGCAACAGCTAAACGATTAACGGACCGCTATCATTCAACGCAGGAGATGTTGCA
GGATTTAAGAACGTCTCTGCAGCCGAATCGCAGCCGTGAAAGAAAGCTTGTTTTCAGTGATGCTTCAGATACAAAACCAC
TACCAAAACTGGAACAGGCAGCAGCAAACTCTTTAGCTGCTCAGTCCTTAAAAAACAAAACTTCCAATCAGGATAAAGTA
GATCATAAATCTAAGCCTAAAACCAAACCACAACCTAAGCCTAAGAAAAAAAGACATTTTTTAGCTCGTTTCTTTAAAAT
CTTCTTTATATTAGTTGCCATTGGTATTGCTGTTTTGACCTACCTGGTTCTGACAAAACCGAGTACTGTTTCAGTTCCTG
ACGTTTCAGGAGATAAATTATCAACGGCCAAGATGATTATTAGAAAATCGGGTCTTAAGGTGGGTGACGTTCAAAAAATT
GAGGATGATAACGTTGGTGCTGGAAAGGTCGTAAGAACTAATCCAAGTGCAGGCAGTAAAAAACGTGAAGGTTCTAGTGT
TGATATTTTTGTAGCTAGTGCTAAGGGATTTAAGATGGAGGACTATACCGGTCAAGACTACAAGGATGCTATTGATAATT
TGACTAATAATTATGGTGTTTCTAGGGATAGTATTGTTCTTAAGGAAGTTTCATCTGATGACTACAGTGGTGGAACTGTT
ATCGGTCAATCACCAAAACCTGGAAAGACCTATCATCCTAGCAGTGATAAAAAAATAACTCTCAAGGTTGTCAAAGTCAC
TATGCCAAATCTTAAAAATTCTACTTATGAAGAGGCTGTCAGTACTTTAACAGCTATGGGGATTTCTTCAAGCCGTATAA
AAGCTTATGATGCCAGCGATTACTCATCAGAAATTTCATCACCATCATCTTCGTCACTCGTTGTCGGTCAAAGTCCTTAT
TATGGTAATACTGTCAGTTTGTCATCTAATGATGATATTATCTTGTATGTTTCAACATCAGGTGGCTCTCATTCTGGTTC
GTCGTCGTCTGAATCTTCGAACAGTGAAGGAACAACATCAAGCGAAGCCTCGACAGACTCTAGTTCAAGTGCGACGACAA
CTTCACATTAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(370-432)

PASTA domain (PASTA)

(506-579)

PASTA domain (PASTA)

(438-505)

Protein kinase domain (Pkinase)

(12-258)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

99.838

100

0.998
  stkP/pknB Streptococcus salivarius strain HSISS4

62.752

96.753

0.607
  stkP Streptococcus pneumoniae TIGR4

52.381

98.864

0.518
  stkP Streptococcus pneumoniae D39

52.217

98.864

0.516
  stkP Streptococcus pneumoniae R6

52.217

98.864

0.516
  stkP Streptococcus pneumoniae Rx1

52.053

98.864

0.515

Multiple sequence alignment