Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   M5005_RS02300 Genome accession   NC_007297
Coordinates   428344..429054 (+) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS5005     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 423344..434054
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M5005_RS02280 (M5005_Spy0431) - 424196..424345 (+) 150 WP_011285429.1 hypothetical protein -
  M5005_RS02285 (M5005_Spy0432) - 424740..425888 (+) 1149 WP_010921988.1 acetyl-CoA C-acyltransferase -
  M5005_RS02290 (M5005_Spy0433) - 425845..427092 (+) 1248 WP_010921989.1 AMP-binding protein -
  M5005_RS02295 (M5005_Spy0434) - 427148..428182 (+) 1035 WP_011285430.1 DUF3114 domain-containing protein -
  M5005_RS02300 (M5005_Spy0435) vicR 428344..429054 (+) 711 WP_002985645.1 response regulator YycF Regulator
  M5005_RS02305 (M5005_Spy0436) vicK 429047..430399 (+) 1353 WP_002995609.1 cell wall metabolism sensor histidine kinase VicK Regulator
  M5005_RS02310 (M5005_Spy0437) vicX 430403..431212 (+) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  M5005_RS02315 (M5005_Spy0438) rnc 431656..432348 (+) 693 WP_002990670.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=24536 M5005_RS02300 WP_002985645.1 428344..429054(+) (vicR) [Streptococcus pyogenes MGAS5005]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=24536 M5005_RS02300 WP_002985645.1 428344..429054(+) (vicR) [Streptococcus pyogenes MGAS5005]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCGCGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTGACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGGCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGCCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364

Multiple sequence alignment