Detailed information NTG0243691

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: LCAKO_RS12620
• Genome accession: NZ_CP022954
• Coordinates: 2562120..2564312 (-)
• Length: 730 a.a.
• NCBI ID: WP_100908635.1
• Uniprot ID: A0AAP9HIX0
• Organism: Lacticaseibacillus paracasei subsp. paracasei strain IBB3423
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2557120..2569312

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LCAKO_RS12590 (LCAKO_2562)	-	2557285..2557569 (-)	285	WP_003567331.1	bacteriocin immunity protein	-
LCAKO_RS12595 (LCAKO_2563)	-	2557763..2558059 (-)	297	WP_003605958.1	bacteriocin immunity protein	-
LCAKO_RS12600 (LCAKO_2564)	-	2558161..2559516 (-)	1356	WP_003567335.1	threonine/serine exporter ThrE family protein	-
LCAKO_RS12605 (LCAKO_2565)	-	2559822..2560133 (-)	312	WP_183419205.1	hypothetical protein	-
LCAKO_RS12610 (LCAKO_2566)	-	2560206..2560556 (-)	351	WP_003567340.1	hypothetical protein	-
LCAKO_RS12615 (LCAKO_2567)	-	2560730..2562109 (-)	1380	WP_128521919.1	bacteriocin secretion accessory protein	-
LCAKO_RS12620 (LCAKO_2568)	comA	2562120..2564312 (-)	2193	WP_100908635.1	peptide cleavage/export ABC transporter	Regulator
LCAKO_RS12625 (LCAKO_2569)	-	2564448..2565464 (+)	1017	WP_003596308.1	IS30 family transposase	-
LCAKO_RS12630 (LCAKO_2570)	-	2565971..2566108 (-)	138	WP_003571414.1	bacteriocin-like peptide, LSEI_2386 family	-
LCAKO_RS12635 (LCAKO_2571)	-	2566298..2567596 (+)	1299	WP_045603255.1	GHKL domain-containing protein	-
LCAKO_RS12640 (LCAKO_2572)	-	2567601..2568407 (+)	807	WP_003567351.1	LytTR family DNA-binding domain-containing protein	-
LCAKO_RS12645	-	2568769..2568966 (-)	198	WP_003661762.1	hypothetical protein	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81290.50 Da
• Isoelectric Point: 7.0227

>NTDB_id=243691 LCAKO_RS12620 WP_100908635.1 2562120..2564312(-) (comA) [Lacticaseibacillus paracasei subsp. paracasei strain IBB3423]
MIKYNLKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDSSVAMTWLPKERFAKEWSGVAIFIAPEPQYQPRKED
KGSLFAFVPMLARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGMIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
SDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHAELLAK
QGYYARLVSE

Nucleotide

• Length: 2193 bp

>NTDB_id=243691 LCAKO_RS12620 WP_100908635.1 2562120..2564312(-) (comA) [Lacticaseibacillus paracasei subsp. paracasei strain IBB3423]
ATGATCAAATACAACCTAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGCTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAGTTGGCGAAGA
CGGATCAGGAAGGAACAACAGCGTTAGGGATTGTCCGAGCTGCTCAGGCACTTCATTTTGAAACCAAGGCTGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTGGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATTCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCGCCAGAACCGCAATATCAACCACGCAAAGAGGAC
AAAGGCAGTCTCTTTGCGTTTGTGCCGATGCTAGCGCGACAAAAAGGAATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATCACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATGATTGCCAGTGGTCTCATCCTCGCTTATGTGCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAACGTTTGTCGATTGATGTCATTTTGGGTTACGTCAGACACCTTTATGAATTACCTATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAAATTGTGTCGCGGTTTTCCGATGCTAATAAAATTATTGATGCGCTGGCGAACACGATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATTTTGAGTTCATCCATTATCGAGGATTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACGTATTTGAAAAAGTCGTTCAATTATACAAAAGCCGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACTAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGGCTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCTATCAATGTGACCGATGTGTCCTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAGCAAATCAATCTTGAAATCCCAGAGAATGCCAAATACACCATTGTCGGCATGAGTGGATCAGGGAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACTGGCAAAGGGAAAATCACATTTAATGGGGTTCCAATC
AGTGATGTTGATCTAACAACGTTACGACAATATATCGAGTATGTACCACAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCAGAAATTGCCG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCAATTGCCCGCGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCAATGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTGACCATTG
CTGCTAAAACGGAACAGATTGTGGTCATGGACCATGGTGCGATTGTTGAACAAGGAAATCATGCTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (16-152)

• ABC transporter (ABC_tran) (510-662)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	58.774	98.356	0.578
comA	Streptococcus pneumoniae Rx1	58.217	98.356	0.573
comA	Streptococcus pneumoniae D39	58.217	98.356	0.573
comA	Streptococcus pneumoniae R6	58.217	98.356	0.573
comA	Streptococcus mitis SK321	58.078	98.356	0.571
comA	Streptococcus pneumoniae TIGR4	57.799	98.356	0.568
comA	Streptococcus gordonii str. Challis substr. CH1	56.964	98.356	0.56
comA/nlmT	Streptococcus mutans UA159	54.848	98.904	0.542