Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   CGZ53_RS04895 Genome accession   NZ_CP022435
Coordinates   941291..941965 (-) Length   224 a.a.
NCBI ID   WP_012658457.1    Uniprot ID   A0A2X4ES39
Organism   Streptococcus uberis strain NZ01     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 936291..946965
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CGZ53_RS04870 (CGZ53_04865) - 936561..937838 (-) 1278 WP_100912049.1 pyrimidine-nucleoside phosphorylase -
  CGZ53_RS04875 (CGZ53_04870) - 937835..938425 (-) 591 WP_012658453.1 class I SAM-dependent methyltransferase -
  CGZ53_RS04880 (CGZ53_04875) coaA 938689..939609 (+) 921 WP_046389364.1 type I pantothenate kinase -
  CGZ53_RS04885 (CGZ53_04880) rpsT 939669..939911 (+) 243 WP_160463058.1 30S ribosomal protein S20 -
  CGZ53_RS04890 (CGZ53_04885) ciaH 939988..941298 (-) 1311 WP_100912050.1 sensor histidine kinase Regulator
  CGZ53_RS04895 (CGZ53_04890) ciaR 941291..941965 (-) 675 WP_012658457.1 response regulator transcription factor Regulator
  CGZ53_RS04900 (CGZ53_04895) - 942087..944624 (-) 2538 WP_100912051.1 M1 family metallopeptidase -
  CGZ53_RS04905 (CGZ53_04900) phoU 944694..945347 (-) 654 WP_012658459.1 phosphate signaling complex protein PhoU -
  CGZ53_RS04910 (CGZ53_04905) pstB 945367..946125 (-) 759 WP_012658460.1 phosphate ABC transporter ATP-binding protein PstB -
  CGZ53_RS04915 (CGZ53_04910) pstB 946138..946941 (-) 804 WP_046390251.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25870.70 Da        Isoelectric Point: 4.3915

>NTDB_id=239386 CGZ53_RS04895 WP_012658457.1 941291..941965(-) (ciaR) [Streptococcus uberis strain NZ01]
MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKDIKTPVLIMTA
KETIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNNNLIRYGNIQVDTDRNMVTVNQENIELLGKEYELLIY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYISKIRKKLKSTDFATNLQTLRSVGYILKSND

Nucleotide


Download         Length: 675 bp        

>NTDB_id=239386 CGZ53_RS04895 WP_012658457.1 941291..941965(-) (ciaR) [Streptococcus uberis strain NZ01]
ATGATAAAACTCTTATTGGTAGAGGATGATTTAAGCTTATCCAATTCCATCTTTGACTTTCTAGATGATTTTGCAGATGT
CATGCAGGTCTTTGATGGTGAAGAAGGACTATACGAGGCAGAAAGTGGTGTCTATGATCTTATTTTATTGGATCTGATGT
TACCAGAAAAAAATGGCTTTCAAGTATTGAAAGAATTAAGAGAAAAAGATATCAAAACACCGGTCTTAATCATGACCGCT
AAGGAAACCATTGATGATAAAGGTCATGGTTTTGAACTAGGAGCGGATGATTATTTAACGAAACCTTTTTATTTAGAAGA
GTTAAAAATGCGCATCCAAGCCTTGCTTAAAAGGTCTGGAAAGTTCAATAATAACCTTATTCGTTACGGGAACATTCAAG
TTGATACAGACCGTAATATGGTTACTGTTAACCAAGAAAACATTGAATTATTAGGTAAAGAATATGAACTTCTAATTTAT
TTTCTACAAAATCAAAATGTCATTCTTCCTAAATCTCAAATTTTTGATCGAATTTGGGGATTTGATAGTGACACAACCAT
CTCAGTAGTAGAGGTTTACATTTCTAAAATTCGAAAAAAACTAAAATCTACTGATTTTGCCACTAATTTACAAACACTAA
GAAGTGTTGGTTATATTTTGAAATCTAATGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(5-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X4ES39

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

87.33

98.661

0.862
  ciaR Streptococcus pneumoniae Rx1

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae D39

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae R6

84.615

98.661

0.835
  ciaR Streptococcus pneumoniae TIGR4

84.615

98.661

0.835
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366

Multiple sequence alignment