Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   QMA0248_RS07665 Genome accession   NZ_CP022392
Coordinates   1556014..1557918 (-) Length   634 a.a.
NCBI ID   WP_003101755.1    Uniprot ID   -
Organism   Streptococcus iniae strain QMA0248     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1551014..1562918
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QMA0248_RS07635 (QMA0248_1545) tnpA 1551175..1551561 (+) 387 Protein_1447 IS200/IS605 family transposase -
  QMA0248_RS07640 (QMA0248_1546) - 1551775..1552131 (-) 357 WP_003101745.1 S1 RNA-binding domain-containing protein -
  QMA0248_RS07645 (QMA0248_1547) - 1552131..1553531 (-) 1401 WP_003101746.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  QMA0248_RS07650 (QMA0248_1548) - 1553564..1554208 (-) 645 WP_003101747.1 response regulator transcription factor -
  QMA0248_RS07655 (QMA0248_1549) - 1554201..1555205 (-) 1005 WP_003101748.1 sensor histidine kinase -
  QMA0248_RS07660 (QMA0248_1550) liaF 1555202..1555897 (-) 696 WP_003101751.1 cell wall-active antibiotics response protein LiaF -
  QMA0248_RS07665 (QMA0248_1551) pknB 1556014..1557918 (-) 1905 WP_003101755.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  QMA0248_RS07670 (QMA0248_1552) - 1557915..1558655 (-) 741 WP_003101757.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  QMA0248_RS07675 (QMA0248_1553) rsmB 1558693..1560015 (-) 1323 WP_003101760.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  QMA0248_RS07680 (QMA0248_1554) fmt 1560005..1560940 (-) 936 WP_003101762.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 634 a.a.        Molecular weight: 69124.80 Da        Isoelectric Point: 8.9521

>NTDB_id=239007 QMA0248_RS07665 WP_003101755.1 1556014..1557918(-) (pknB) [Streptococcus iniae strain QMA0248]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEEVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYIQGADLKKFIQDNAPLSNTQVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKSGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENPQVP
QALENVVIKATAKKLSDRYNSTFEMSRDLMTALSYNRSRERKLVFLDVESTKPLPKVTPTPAPKPTVAPVSPSNTTKQKQ
EAIADVPVKKKKSGRFFGTLLKIIFALFVIGVAFFAFLVLTKPSTVKVPNVNGSSLAVAESELKSLGFKIGKVKEIESAT
VAEGNVVKTDPEAGTSKREGSKVDIYVSIGNQSFVMEDYKNQLYEDAVENLVNTYNVPRSKIKIERVVTSDYRKDMVIAQ
SPSPGEKFNPKGKSKIVLSVASNDTVLMPTIVNYTYQDALAALKALGIDSKRVKAYYPDVNSATGFSKMPNPKSTMIISA
QDPYAGVEISLSATSEISIYLYAEEPTANSSDTTTSSNSRSTASSSESHATSSSSSNPNAGTETNTDANVSPQN

Nucleotide


Download         Length: 1905 bp        

>NTDB_id=239007 QMA0248_RS07665 WP_003101755.1 1556014..1557918(-) (pknB) [Streptococcus iniae strain QMA0248]
ATGATACAGATTGGCAAATTATTTGCTGGTCGTTATCGCATCTTAAAATCAATTGGCCGCGGTGGTATGGCGGATGTTTA
CTTAGCCAATGACTTAATCTTAGATAATGAAGAAGTTGCAATTAAAGTTTTGCGAACCAATTATCAAACAGATCAAGTTG
CAGTAGCGCGTTTCCAAAGAGAAGCGCGAGCGATGGCAGAATTAAATCATCCCAACATTGTCGCTATTCGAGATATAGGT
GAAGAAGACGGACAGCAGTTCTTAGTAATGGAATATATCCAGGGCGCTGACCTTAAGAAATTTATTCAAGATAACGCTCC
TTTGTCTAACACCCAAGTTGTTAGAATCATGGAAGAAGTTTTATCTGCTATGACATTAGCCCACCAAAAAGGGATTGTTC
ATAGAGACTTGAAACCTCAAAATATTCTATTAACAAAGTCAGGTGTTGTCAAAGTTACAGACTTTGGTATTGCTGTAGCT
TTTGCTGAAACTAGTTTAACGCAGACAAATTCCATGTTAGGAAGTGTGCATTATTTATCACCAGAACAAGCCCGTGGTTC
AAAAGCCACCATTCAAAGTGATATTTATGCCATGGGAATTATGCTCTTTGAAATGTTAACAGGTCATATCCCATATGATG
GTGATAGTGCTGTTACAATTGCATTGCAGCATTTCCAAAAACCCCTTCCTTCAATTATTGACGAGAACCCGCAAGTTCCA
CAGGCTTTAGAAAATGTTGTTATTAAGGCAACTGCTAAAAAGTTAAGTGATCGTTACAATTCGACATTTGAAATGAGTCG
CGACCTAATGACTGCACTAAGTTATAATCGAAGCCGTGAACGCAAGTTAGTCTTTTTGGATGTTGAAAGCACAAAACCCT
TACCAAAAGTAACCCCGACCCCAGCACCAAAACCAACGGTAGCTCCGGTAAGTCCAAGTAATACCACTAAACAAAAACAA
GAAGCCATTGCTGATGTGCCTGTTAAGAAAAAAAAGAGTGGGCGTTTCTTTGGAACTTTATTAAAGATTATTTTTGCACT
ATTTGTTATCGGTGTTGCGTTTTTTGCCTTTCTTGTCTTGACCAAGCCATCTACCGTAAAAGTTCCAAATGTTAATGGAA
GTAGTCTAGCGGTTGCTGAATCAGAGTTAAAATCTTTAGGGTTTAAGATTGGAAAAGTAAAAGAAATTGAGAGTGCAACC
GTTGCAGAAGGTAATGTTGTTAAAACAGATCCAGAAGCTGGAACTTCAAAACGCGAAGGCTCTAAGGTTGATATTTATGT
TTCAATAGGTAATCAGAGTTTTGTGATGGAAGATTATAAAAATCAACTTTACGAAGATGCCGTTGAAAACCTTGTTAACA
CCTACAATGTTCCAAGGTCGAAAATTAAAATTGAAAGAGTGGTAACATCCGACTATCGTAAGGATATGGTTATTGCCCAG
TCACCTAGTCCAGGTGAGAAATTTAATCCCAAAGGAAAATCGAAGATTGTCCTCAGTGTGGCTAGTAATGACACAGTTTT
AATGCCAACTATTGTTAACTATACTTATCAGGATGCCCTTGCAGCACTAAAAGCTTTAGGAATTGACAGTAAGCGTGTCA
AAGCTTATTATCCTGATGTTAACTCTGCTACTGGCTTTAGCAAGATGCCTAATCCAAAATCAACAATGATTATCAGCGCA
CAAGATCCATATGCAGGTGTAGAGATTTCCTTATCTGCTACTAGCGAGATTAGCATTTACCTTTATGCTGAAGAACCAAC
AGCCAATAGTTCTGATACAACAACATCATCAAACAGTCGAAGTACAGCATCAAGTAGTGAGAGTCATGCCACAAGCAGCT
CATCCTCTAACCCTAACGCAGGTACCGAAACAAACACCGATGCCAATGTATCACCTCAAAACTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-241)

PASTA domain (PASTA)

(366-428)

PASTA domain (PASTA)

(435-501)

PASTA domain (PASTA)

(506-582)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

63.884

92.587

0.591
  stkP/pknB Streptococcus salivarius strain HSISS4

63.763

90.536

0.577
  stkP Streptococcus pneumoniae TIGR4

56.977

81.388

0.464
  stkP Streptococcus pneumoniae D39

56.589

81.388

0.461
  stkP Streptococcus pneumoniae R6

56.589

81.388

0.461
  stkP Streptococcus pneumoniae Rx1

56.395

81.388

0.459

Multiple sequence alignment