Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   CO646_RS01405 Genome accession   NZ_CP022340
Coordinates   287462..288766 (-) Length   434 a.a.
NCBI ID   WP_010736524.1    Uniprot ID   A0A1V2ULD8
Organism   Enterococcus mundtii strain EMB156     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 282462..293766
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CO646_RS01370 - 282888..283847 (-) 960 WP_062805833.1 glycosyltransferase family 2 protein -
  CO646_RS01375 - 283986..284336 (-) 351 WP_019724280.1 PepSY domain-containing protein -
  CO646_RS01380 pepA 284538..285617 (+) 1080 WP_096081324.1 glutamyl aminopeptidase -
  CO646_RS01385 - 285741..286061 (+) 321 WP_010736528.1 thioredoxin family protein -
  CO646_RS01390 - 286083..286538 (+) 456 WP_010736527.1 universal stress protein -
  CO646_RS01395 - 286590..286811 (+) 222 WP_010736526.1 hypothetical protein -
  CO646_RS01400 ytpR 286808..287413 (+) 606 WP_010736525.1 YtpR family tRNA-binding protein -
  CO646_RS01405 htrA 287462..288766 (-) 1305 WP_010736524.1 S1C family serine protease Regulator
  CO646_RS01410 rlmH 289195..289674 (+) 480 WP_010736523.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  CO646_RS01415 - 290029..290424 (+) 396 WP_010736522.1 hypothetical protein -
  CO646_RS01420 - 290354..291688 (+) 1335 WP_155237708.1 hypothetical protein -
  CO646_RS01425 - 291685..292254 (+) 570 WP_010736520.1 hypothetical protein -
  CO646_RS01430 - 292244..292582 (+) 339 WP_010736519.1 DUF4176 domain-containing protein -
  CO646_RS01435 - 292783..293376 (+) 594 WP_010736518.1 hypothetical protein -

Sequence

Protein


Download         Length: 434 a.a.        Molecular weight: 45080.01 Da        Isoelectric Point: 4.4838

>NTDB_id=238380 CO646_RS01405 WP_010736524.1 287462..288766(-) (htrA) [Enterococcus mundtii strain EMB156]
MDRRDVTPKMKKRKSNGIWRKLGLGVVGGVIGGLLTFGIFYAATGGGNSVTTSSSSGTQNASGETVVENVKVNVDSDITS
AVDKVQGAVVSVINLQKQSSSSDPFGSLFGQQQESSGEDGELQAYSEGSGVIYKKEGGSAYIVTNNHVVDGQQGLEVLLK
DGTKVKAELVGTDAYTDLAVLKISADKVDTVASFGDSASLKVGEPAIAIGSPLGSQYANSVTSGIISSLNRQVTSTNESN
ETVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSDSSSVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMTDLSAVSTQQQEQILKLPSSVTNGVIIRSVQPATPAEKAGLEQYDVITKIDDTEVSSGVELQSVLYGKKVGDTVKIT
YYRGEEEKTVDIKLTIDNTALNQGNSNSSNGSNN

Nucleotide


Download         Length: 1305 bp        

>NTDB_id=238380 CO646_RS01405 WP_010736524.1 287462..288766(-) (htrA) [Enterococcus mundtii strain EMB156]
ATGGACAGAAGAGATGTGACACCAAAAATGAAAAAAAGAAAATCTAATGGCATTTGGCGAAAGCTAGGTCTTGGCGTAGT
TGGTGGCGTGATTGGCGGATTACTGACTTTCGGTATTTTTTATGCAGCAACTGGAGGTGGTAACTCAGTAACGACTTCTT
CTAGCAGTGGGACACAAAATGCATCAGGCGAAACAGTTGTCGAAAATGTAAAAGTCAATGTAGATTCAGATATCACTTCT
GCAGTAGATAAAGTACAAGGAGCAGTTGTTTCTGTTATCAACCTACAAAAACAAAGTTCATCATCTGACCCGTTTGGTTC
ATTATTTGGCCAACAACAAGAAAGTAGTGGCGAAGATGGCGAATTGCAAGCTTACAGTGAAGGTAGCGGTGTGATCTATA
AAAAAGAGGGCGGTTCCGCTTATATCGTGACGAATAATCACGTGGTCGATGGACAACAAGGGTTAGAAGTTTTATTAAAA
GATGGAACAAAAGTGAAAGCAGAATTAGTCGGTACAGATGCTTACACTGATTTAGCTGTGTTGAAAATCAGTGCTGACAA
AGTCGACACTGTTGCTTCATTTGGCGATTCTGCTTCATTGAAAGTCGGCGAACCTGCGATTGCGATTGGTTCTCCTCTAG
GTTCTCAATACGCGAATTCCGTAACATCAGGGATCATTTCTTCCTTGAATCGCCAAGTGACAAGTACCAATGAATCTAAT
GAAACGGTCAATATCAACGCGATTCAAACAGATGCAGCGATCAACCCGGGGAACTCTGGTGGTCCACTAGTTAATATCGA
AGGACAAGTCATTGGTATCAATTCAAGTAAAATTGCATCGACTTCTGATTCTTCAAGTGTAAGTGTTGAAGGAATGGGCT
TTGCGATTCCAAGTAATGATGTCGTAAATATCATCAATCAACTTGAAAAAGATGGAAAAGTAACACGCCCTGCACTGGGT
ATCACAATGACCGATCTTTCCGCCGTTTCTACACAACAACAGGAACAGATCTTGAAATTACCATCTTCTGTAACAAATGG
CGTGATCATTCGTTCGGTTCAACCAGCAACGCCTGCGGAAAAAGCTGGCTTAGAACAATATGATGTCATCACAAAAATCG
ATGATACAGAAGTCTCATCTGGTGTTGAATTACAGTCTGTGCTTTATGGTAAAAAAGTTGGTGACACTGTGAAGATCACT
TATTACCGTGGCGAAGAAGAAAAAACTGTAGATATCAAATTGACAATTGATAATACTGCATTAAATCAAGGAAATTCAAA
TAGTTCCAATGGCTCAAATAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(13-416)

Trypsin-like peptidase domain (Trypsin_2)

(128-273)

PDZ domain (PDZ_2)

(317-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1V2ULD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

56.01

90.092

0.505
  htrA Streptococcus gordonii str. Challis substr. CH1

51.852

93.318

0.484
  htrA Streptococcus mitis NCTC 12261

52.778

91.244

0.482
  htrA Streptococcus pneumoniae Rx1

58.631

77.419

0.454
  htrA Streptococcus pneumoniae D39

58.631

77.419

0.454
  htrA Streptococcus pneumoniae R6

58.631

77.419

0.454
  htrA Streptococcus pneumoniae TIGR4

58.631

77.419

0.454

Multiple sequence alignment