Detailed information NTG0237157

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: C7K40_RS01250
• Genome accession: NZ_CP027771
• Coordinates: 221182..221922 (+)
• Length: 246 a.a.
• NCBI ID: WP_080465136.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain DMG1800716
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 216182..226922

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C7K40_RS01235 (C7K40_01235)	gltX	216712..218157 (+)	1446	WP_063629552.1	glutamate--tRNA ligase	-
C7K40_RS01240 (C7K40_01240)	-	218552..219898 (+)	1347	WP_002991186.1	sensor histidine kinase	-
C7K40_RS01245 (C7K40_01245)	-	219895..221178 (+)	1284	WP_010921869.1	sensor histidine kinase	-
C7K40_RS01250 (C7K40_01250)	comE/blpR	221182..221922 (+)	741	WP_080465136.1	LytTR family DNA-binding domain-containing protein	Regulator
C7K40_RS01255 (C7K40_01255)	rnpA	222462..222821 (+)	360	WP_002992035.1	ribonuclease P protein component	-
C7K40_RS01260 (C7K40_01260)	-	222787..223614 (+)	828	WP_002991181.1	YidC/Oxa1 family membrane protein insertase	-
C7K40_RS01265 (C7K40_01265)	jag	223626..224540 (+)	915	WP_023613238.1	RNA-binding cell elongation regulator Jag/EloR	-
C7K40_RS01270 (C7K40_01270)	rpmH	224855..224989 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
C7K40_RS01275 (C7K40_01275)	-	225263..225967 (+)	705	WP_063629553.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28937.59 Da
• Isoelectric Point: 6.8298

>NTDB_id=237157 C7K40_RS01250 WP_080465136.1 221182..221922(+) (comE/blpR) [Streptococcus pyogenes strain DMG1800716]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTRTERLEFYGNLSEIQVVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=237157 C7K40_RS01250 WP_080465136.1 221182..221922(+) (comE/blpR) [Streptococcus pyogenes strain DMG1800716]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCGGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGTAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTTCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37